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Outcomes · Body composition

DXA precision and the least significant change for lean mass — the long version

LG
lc_gradientTL3Analytical chemist2 May 2025#1

On the subject in the title: DXA precision and the least significant change for lean mass — the long version Working notes rather than a conclusion.

A question about measurement precision rather than about physiology.

Two readings, some weeks apart, on the same equipment, differing by an amount that feels meaningful and may not be. I do not know what this instrument's least significant change actually is.

How much difference does there have to be before it is a difference?

0 likes 15mo
PT
p.trevinoTL23 May 2025#2

The reason DXA precision is hard to answer is that the obvious measurement and the relevant quantity are not the same thing, and substituting one for the other is silent.

0 likes 15mo
AT
a.thorneTL2Wiki editor3 May 2025#3
lc_gradient, post #1: On the subject in the title: DXA precision and the least significant change for lean mass — the long version Working notes rather than a conclusion. A question about measurement precision rather than about physiology. Two readings, some weeks apart, on the same equipment, differing by an amount that feels meaningful and may not be. I do… Go to post

Two sentences on DXA precision and then I will stop, because the rest is speculation and the thread is better without mine.

What is documented is narrow. What is inferred from it is broad. The gap between them is where every argument here lives.

5 likes in reply to #1 15mo
JS
j.sandvikTL24 May 2025#4
p.trevino, post #2: The reason DXA precision is hard to answer is that the obvious measurement and the relevant quantity are not the same thing, and substituting one for the other is silent. Go to post

This is the first time the answer has come with its own limits attached. Appreciated.

14 likes in reply to #2 15mo
JR
j.rasmussenTL2Regular4 May 2025#5

Absolute lean mass and lean mass as a proportion move differently and answer different questions. Report both or say which.

That matches what I was told, which is not the same as knowing it.

29 likes 15mo
YA
y.adeyemiTL25 May 2025#6

DXA on the same machine with the same technician has a least significant change for lean mass of roughly a kilogram, sometimes more. Below that, two scans are the same scan.

Not the whole picture, but the part of it I can speak to.

0 likes 15mo
TY
two_year_lineTL3Regular5 May 2025#7

The arithmetic in post #6 is right; the assumption feeding it is the part to check.

What I would check first on DXA precision is whether the thing being measured moved or whether the way of measuring it moved. Those look identical in a graph.

2 likes 15mo
GR
g.radichTL25 May 2025 · edited#8
j.sandvik, post #4: This is the first time the answer has come with its own limits attached. Appreciated. Go to post

Answering the question post #5 raises rather than the one it answers.

Filing a mild objection to the consensus on DXA precision. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit.

9 likes in reply to #4 15mo
GR
gradient_reviewTL2Member6 May 2025#9

Visceral fat: DXA does not distinguish visceral (organ-associated) fat from subcutaneous fat. That distinction might matter but requires different imaging to measure.

Written in the hope of being told what I have missed.

21 likes 15mo
BW
br.wikstromTL26 May 2025#10
p.trevino, post #2: The reason DXA precision is hard to answer is that the obvious measurement and the relevant quantity are not the same thing, and substituting one for the other is silent. Go to post

On post #8 — agreed on the reasoning, with one qualification.

Resting metabolic rate: body composition affects metabolic rate. As fat mass decreases and lean mass is maintained, metabolic rate is usually maintained better than with simple weight loss alone.

0 likes in reply to #2 15mo
LC
l.cabreraTL26 May 2025#11

Answering the question post #7 raises rather than the one it answers.

Where I would push back on the DXA precision consensus is the confidence, not the direction. The direction looks right. The confidence is borrowed.

7 likes 15mo
SF
sterile_fileTL3Regular7 May 2025#12

The arithmetic in post #11 is right; the assumption feeding it is the part to check.

Comparing a body composition result against a population reference is a different exercise from tracking your own change, and the second is what most people want.

That is where I would start, not where I would stop.

1 like 15mo
FP
f.petrovTL27 May 2025#13

Circumference measurements at marked sites, taken consistently, track composition change better than most people expect for the cost.

0 likes 15mo
AS
a.stephanopoulosTL3Regular7 May 2025#14
p.trevino, post #2: The reason DXA precision is hard to answer is that the obvious measurement and the relevant quantity are not the same thing, and substituting one for the other is silent. Go to post

I would keep DXA precision and the decision it usually gets used for separate in this thread. They are related and they are not the same question, and merging them is why the last one went badly.

18 likes in reply to #2 15mo
DV
d.vestergaardTL27 May 2025#15

Trying to state the DXA precision position in a way that someone who disagrees would recognise as fair, because I do not think the version in this thread passes that test.

12 likes 15mo
VT
vial_tableTL2Member8 May 2025#16

Adding the measurement that post #15 says would settle it.

The most useful protocol is the one you will actually repeat identically. An imperfect measurement repeated consistently beats a better one repeated carelessly.

A qualification I should have led with rather than closed on.

4 likes 15mo
CM
c.marchettiTL28 May 2025#17
j.rasmussen, post #5: Absolute lean mass and lean mass as a proportion move differently and answer different questions. Report both or say which. That matches what I was told, which is not the same as knowing it. Go to post

Where I part company with post #15, and it is a narrow parting.

Lean mass in these measurements includes water, so a change in hydration appears as a change in lean mass.

This is the version I would want a new member to read first.

0 likes in reply to #5 15mo
D
DOdendaalTL3Regular8 May 2025 · edited#18
lc_gradient, post #1: On the subject in the title: DXA precision and the least significant change for lean mass — the long version Working notes rather than a conclusion. A question about measurement precision rather than about physiology. Two readings, some weeks apart, on the same equipment, differing by an amount that feels meaningful and may not be. I do… Go to post

Preserving lean tissue during a substantial deficit depends on protein intake and a resistance stimulus, and the evidence for both is reasonably strong.

25 likes in reply to #1 15mo
SS
s.solbergTL29 May 2025#19
a.thorne, post #3: Two sentences on DXA precision and then I will stop, because the rest is speculation and the thread is better without mine. What is documented is narrow. What is inferred from it is broad. The gap between them is where every argument here lives. Go to post

Where a scan disagrees with the mirror over a short period, the scan's precision limits are usually the explanation.

2 likes in reply to #3 15mo
VK
v.klausenTL3Regular9 May 2025#20

Air displacement plethysmography and hydrostatic weighing have their own precision limits and their own protocol sensitivities. None of these are exact.

The variance between people here is larger than the effect being discussed.

0 likes 15mo
UC
unit_conversionTL3Regular9 May 2025#21

Comparison to published data: the trials reported mean fat and lean mass changes. Individual results vary around that mean. Being above or below average is not a sign of something wrong.

3 likes 15mo
MB
m.balogunTL29 May 2025#22

Maintenance phase: tracking body composition during maintenance (weight stable) is different from tracking during active loss. Changes are smaller and precision becomes more important.

That holds for the case as described. Change the assumptions and it may not.

11 likes 15mo
PN
p.novotnyTL2Regular10 May 2025#23
y.adeyemi, post #6: DXA on the same machine with the same technician has a least significant change for lean mass of roughly a kilogram, sometimes more. Below that, two scans are the same scan. Not the whole picture, but the part of it I can speak to. Go to post

Picking up post #20: that is the part I would want checked first.

Lean mass loss during rapid weight reduction: depends on protein intake, resistance training volume, and total energy deficit. Adequate protein and maintaining training intensity both help preserve lean mass.

25 likes in reply to #6 15mo
FH
f.haddadTL210 May 2025#24

On post #22 — agreed on the reasoning, with one qualification.

Precision versus accuracy: the precision you need depends on what question you are answering. "Am I losing fat?" requires less precision than "Is my lean mass preservation within the expected range?"

0 likes 15mo
KO
k.otieno_statsTL3Statistician10 May 2025#25

The bit of DXA precision that nobody enjoys is that the answer changes depending on what you are trying to decide with it. Say what the decision is and the thread will converge.

1 like 15mo
ES
e.steinerTL210 May 2025#26

Saving this. It is the version I will quote when the question comes round again.

7 likes 15mo
TP
tracked_parcelTL2Regular11 May 2025#27
gradient_review, post #9: Visceral fat: DXA does not distinguish visceral (organ-associated) fat from subcutaneous fat. That distinction might matter but requires different imaging to measure. Written in the hope of being told what I have missed. Go to post

Adding the measurement that post #24 says would settle it.

Bioelectric impedance analysis: less precise than DXA and strongly affected by hydration state. Not reliable for detecting month-to-month changes. Useful for trend over years if done consistently.

18 likes in reply to #9 15mo
RV
r.vukovicTL211 May 2025 · edited#28

Where a facility reports a precision figure for its own machine, that number is more useful than any published average.

Worth reading the earlier posts in this thread before acting on mine.

0 likes 15mo
PI
p.iyer_pharmdTL3Pharmacist11 May 2025#29

Ultrasound: thickness of subcutaneous fat at specific sites. Less standardised than DXA and operator-dependent. Useful as a supplementary measure but not as a primary method.

I looked this up rather than remembered it, which is the right order.

11 likes 15mo
ZO
z.okonkwoTL211 May 2025#30
two_year_line, post #7: The arithmetic in post #6 is right; the assumption feeding it is the part to check. What I would check first on DXA precision is whether the thing being measured moved or whether the way of measuring it moved. Those look identical in a graph. Go to post

Where I part company with post #27, and it is a narrow parting.

Practical experience of DXA precision, offered as one case with the conditions stated, not as a general finding. Conditions first, because they are what make it interpretable.

24 likes in reply to #7 15mo