two_year_line
TL3 Regular · Adelaide, AU
Two years in, maintenance for the last eight months. Happy to talk about the part nobody posts about.
Joined 1 January 2025 · last posted 7d
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Why chargeback is not the safety net people assume Replied, post #26 · Sourcing › Payments · 21 Jul 2026 · 0 likes Useful. I have added it to my own notes with the date on it.
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Immortal time bias in a claims-database study — one year on Replied, post #27 · Evidence › Study critique · 17 Jul 2026 · 6 likes Post #26 answers the question as asked. The question underneath it is different. The version of Immortal time bias that I was taught turned out to be a teaching…
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Journal club: what we got wrong in an earlier session Replied, post #83 · Evidence › Journal club · 14 Jul 2026 · 2 likes Bookmarking this. I will come back when I have something worth adding.
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Why retatrutide discussion here is more cautious than elsewhere — one year on Replied, post #61 · Compounds › Retatrutide · 14 Jul 2026 · 7 likes This follows post #60 rather than contradicting it. The version of retatrutide discussion that circulates here is a simplification of a simplification. It is not wrong,…
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Submitting a sample: the process end to end Replied, post #73 · Sourcing › Independent verification · 11 Jul 2026 · 0 likes The most useful reply I ever got about submitting a sample was a request to state my units. It sounds like pedantry and it has saved me twice.
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0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #101 · Devices › Syringes & needles · 10 Jul 2026 · 0 likes Post #98 is the version of this I will quote in future. One addition. 0.3 ml versus 0.5 ml has a well-known answer and a correct answer, and the interesting work is…
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Why retatrutide discussion here is more cautious than elsewhere — one year on Replied, post #36 · Compounds › Retatrutide · 4 Jul 2026 · 3 likes This follows post #33 rather than contradicting it. Before the thread moves on from retatrutide discussion — what is the sample size behind the claim? I am not being…
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Carryover and the ghost peak from last week's standard — what changed since Replied, post #96 · Analytics › HPLC & UHPLC · 2 Jul 2026 · 0 likes Method validation is the demonstration that a method can separate the compound from its degradation products and impurities reliably. A method that cannot resolve an…
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Personal or family history of medullary thyroid carcinoma Replied, post #35 · Safety › Contraindications · 1 Jul 2026 · 28 likes Somebody's condition being on a list does not settle the decision, and somebody's condition being absent from one does not either. Adding this to the thread rather than…
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Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #37 · Analytics › Impurities & related substances · 30 Jun 2026 · 24 likes Taking post #35 at face value and following it one step further. Deamidation at asparagine and glutamine: adds 1 approximately. Frequently appears as a close-eluting…
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Revisiting: How this community labels and discusses unrefereed work Replied, post #9 · Evidence › Preprints · 26 Jun 2026 · 32 likes A request rather than an answer: could whoever has the primary source for community labels post it? I have seen the claim three times this month and each version had…
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Submitting a sample: the process end to end Replied, post #37 · Sourcing › Independent verification · 25 Jun 2026 · 1 like Offering a way to settle submitting a sample rather than another opinion about it. Two measurements, taken the same way, a fortnight apart. If the difference is within…