Topic summary

Follow-up: Why the titration planner refuses to produce a schedule below a floor

Data & Tools › Calculators worked example syringe units site feedback

This is a generated summary. It shows the 9 most-liked posts from a topic of 147, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

chromatogramTL4Analytical chemist7 May 2025#1

The question in the title: Why the titration planner refuses to produce a schedule below a floor I will give what I have already checked below so nobody repeats it.

A follow-up question about titration planner refuses that I did not know to ask the first time.

The earlier thread answered what I asked. What I should have asked is below, and I think it is the one that matters.

29 likes 15mo

m.steinerTL22 Jun 2025#16

Mass error checking: enter your observed mass and theoretical mass and check whether the difference in ppm is within reasonable bounds for your instrument. Useful sanity check on LC-MS results.

Reading it back, the second half matters more than the first.

31 likes 14mo

f.fontaineTL224 Jun 2025#33

o.abrahamsen, post #24: I would put moderate confidence on the mainstream reading of titration planner refuses and no more. That is not scepticism for its own sake; it is where the sourcing actually stops. Go to post

Building on post #30 rather than restating it.

I read the earlier replies on titration planner refuses twice before writing this, because I had assumed the opposite and wanted to be sure I was disagreeing with what was said rather than what I expected.

30 likes in reply to #24 13mo

a.ilungaTL210 Jul 2025#47

l.lundgren, post #27: I had written a reply contradicting post #23 and deleted it. Here is what survived. Worth separating titration planner refuses as a question about the compound from titration planner refuses as a question about the documentation. They get answered by different people and only one of them is answerable here. Go to post

Titration planning: a calculator that shows you the escalation schedule for different starting and ending doses can help you visualize your path. Actual path might be slower or adjusted for tolerability.

This is the sort of thing that ought to be settled and apparently is not.

32 likes in reply to #27 13mo

FairweatherTL2Member13 Aug 2025#81

h.delgado, post #12: Worth separating two things that post #10 runs together. A titration planner is a scheduling aid rather than a clinical recommendation, and any tool that presents one as the other is overstepping. The short version is the first sentence; the rest is why. Go to post

Post #77 put the caveat in the right place and I want to underline it.

Significant figures in the output should not exceed what the inputs support. A concentration calculated from a nominal vial mass is not known to four decimal places.

The uncertainty is in the assumption, not in the calculation.

31 likes in reply to #12 11mo

p.friskTL221 Aug 2025#90

j.bhattacharya, post #64: Adding the measurement that post #62 says would settle it. A note on scope: what I am saying about titration planner refuses applies to the case in the first post and I would not extend it further without checking. Go to post

Acknowledging rather than arguing. The reasoning holds as far as I can follow it.

29 likes in reply to #64 11mo

s.lindqvistTL21 Sep 2025#101

Reporting rather than recommending, on titration planner refuses. What happened is above. Whether it should have is a different question and not one I am qualified to answer.

29 likes 11mo

f.novakTL210 Sep 2025#111

Post #107 and I disagree about the size of the effect, not about the direction.

Titration planner refuses is worth one more sentence than it usually gets, and the sentence is the one about how the number was arrived at.

32 likes 11mo

h.koodziejTL2Member22 Sep 2025#125

p.lindqvist, post #56: Post #54 and I disagree about the size of the effect, not about the direction. A tool that refuses to give an answer when the result falls below one graduation is doing something useful. Most just print the number. That is one dataset and I would not build a rule on it. Go to post

A tool that refuses to give an answer when the result falls below one graduation is doing something useful. Most just print the number.

That has been true for the cases I have seen and I have not seen many.

30 likes in reply to #56 10mo

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