Building on post #2 rather than restating it.
A clinician's reasoning in this situation typically weighs mechanism, related-population data and the consequences of doing nothing. Naming those three makes the discussion tractable.
28 likes 12mo
Topic summary
Hepatic impairment and the absence of data
This is a generated summary. It shows the 5 most-liked posts from a topic of 36, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.
Answering the question post #11 raises rather than the one it answers.
Body weight at the extremes of the studied range affects exposure and the trials rarely reported enough to say by how much.
29 likes 11mo
c.ramos, post #15: Adding the measurement that post #12 says would settle it. Before the thread moves on from hepatic impairment — what is the sample size behind the claim? I am not being difficult; I have seen the same figure quoted from an n of four and from an n of four hundred. Go to post
A clinician's reasoning in this situation typically weighs mechanism, related-population data and the consequences of doing nothing. Naming those three makes the discussion tractable.
That matches what I was told, which is not the same as knowing it.
Read the full topic (36 posts)
This topic was referenced in
- Hepatic impairment and the absence of data — a second datasetClinical › Special populations · 2 replies
- Coming back to: Bariatric surgery history: altered anatomy, altered expectationsClinical › Special populations · 2 replies
Suggested topics
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Coming back to: Bariatric surgery history: altered anatomy, altered expectations
Bariatric surgery history: altered anatomy, altered expectations Writing it up because I had to work it out twice and would rather nobody else did. Bariatric surgery history — I have the observation and I do…
|
2 | 38k | 15mo | |
|
Adolescents: a distinct evidence base — one year on
Posting this under the heading it deserves: Adolescents: a distinct evidence base — one year on Everything below is what sits behind that. A methods question rather than a substantive one, about Adolescents.…
|
+78 | 88 | 9.3k | 3mo |
|
Follow-up: History of disordered eating and why it changes the conversation
Posting this under the heading it deserves: History of disordered eating and why it changes the conversation Everything below is what sits behind that. What changes if the standard account of History of…
|
+75 | 81 | 23k | 10mo |
|
[2026 update] People with a low starting BMI: where the evidence stops
People with a low starting BMI: where the evidence stops Writing it up because I had to work it out twice and would rather nobody else did. Asking about a population rather than about a person. The published…
|
+19 | 23 | 62k | 23mo |
|
Coming back to: Renal impairment: what the labelling says about dose
Renal impairment: what the labelling says about dose — setting out what I have, and where I think it stops being reliable. Renal impairment — I have the observation and I do not trust my interpretation of it,…
|
+30 | 34 | 48k | 18mo |
Related topics — sharing the tags older adults, adolescents, chronic kidney disease
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
When to stop reading forums, including this one — the long version
Asking directly, because I could not find a straight answer: When to stop reading forums, including this one — the long version Something that has come up for me and that I suspect is more common than the…
|
+23 | 27 | 8.3k | 14mo |
|
Second pass at: Pregnancy and pregnancy planning: contraindication and washout
Second pass at: Pregnancy and pregnancy planning: contraindication and washout Writing it up because I had to work it out twice and would rather nobody else did. Something about Pregnancy and pregnancy…
|
+111 | 127 | 1.6k | 6mo |
|
Second pass at: Obstructive sleep apnoea and a hard endpoint in this class
Second pass at: Obstructive sleep apnoea and a hard endpoint in this class — setting out what I have, and where I think it stops being reliable. Something about Obstructive sleep apnoea does not reconcile and…
|
2 | 726 | 14mo | |
|
Pregnancy and pregnancy planning: contraindication and washout
Posting this under the heading it deserves: Pregnancy and pregnancy planning: contraindication and washout Everything below is what sits behind that. Pregnancy and pregnancy planning: setting out the…
|
+111 | 122 | 2.4k | 3mo |
|
Adolescents: a distinct evidence base — one year on
Posting this under the heading it deserves: Adolescents: a distinct evidence base — one year on Everything below is what sits behind that. A methods question rather than a substantive one, about Adolescents.…
|
+78 | 88 | 9.3k | 3mo |