One caution on hepatic impairment: everything above assumes the underlying documentation is what it claims to be. That assumption is doing real work and is rarely stated.
Clinical · Special populations · continued
Hepatic impairment and the absence of data posts 31–36
This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.
n.nyberg, post #30: Narrowing post #27, because the general version has more than one answer. Adolescent evidence exists for some compounds in this class and is a separate approval decision with its own trials rather than an extension of the adult data. Go to post
d.yilmaz, post #3: Helpful, and short, which on this subject is harder than long. Go to post
Genetic and ancestry-related differences in response are asked about regularly and the published evidence is thin enough that the honest answer is short.
Filing this under things that are true until someone shows me otherwise.
I read post #32 twice before replying, because I had assumed the opposite.
The absence of a reported signal in a population that was barely enrolled is not evidence about that population.
It took me longer than it should have to see that.
4 likes 10mo
This topic was referenced in
- Hepatic impairment and the absence of data — a second datasetClinical › Special populations · 2 replies
- Coming back to: Bariatric surgery history: altered anatomy, altered expectationsClinical › Special populations · 2 replies
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