A history of pancreatitis appears in the cautions for this class and the decision around it is one that needs a clinician who knows the history.
On the subject in the title: Hepatic steatosis: what the MASH trial evidence supports — one year on Working notes rather than a conclusion.
Reading back through what has been written here about Hepatic steatosis, three questions come up every time and only one has ever been answered properly.
Listing all three, with what I think the state of the answer is for each, so the thread can start further along than the last one did.
A history of pancreatitis appears in the cautions for this class and the decision around it is one that needs a clinician who knows the history.
A condition being an exclusion criterion in a trial does not mean the treatment is contraindicated. It frequently means the trialists wanted a cleaner population.
On balance I think that is right, and I would not bet much on it.
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Osteoarthritis and mechanical versus metabolic improvement — one year on
On the subject in the title: Osteoarthritis and mechanical versus metabolic improvement — one year on Working notes rather than a conclusion. Collecting what is known about Osteoarthritis and mechanical…
|
+52 | 56 | 8.1k | 15d |
|
Obstructive sleep apnoea and a hard endpoint in this class
On the subject in the title: Obstructive sleep apnoea and a hard endpoint in this class Working notes rather than a conclusion. I was wrong about obstructive sleep apnoea in a thread last spring and I would…
|
+120 | 129 | 1.8k | 13mo |
|
Osteoarthritis and mechanical versus metabolic improvement
Osteoarthritis and mechanical versus metabolic improvement Writing it up because I had to work it out twice and would rather nobody else did. Asking about osteoarthritis and mechanical versus metabolic…
|
+2 | 6 | 30k | 12h |
|
PCOS and metabolic overlap: what is and is not studied
On the subject in the title: PCOS and metabolic overlap: what is and is not studied Working notes rather than a conclusion. PCOS and metabolic overlap, from the point of view of someone who has read the…
|
3 | 6.6k | 1d | |
|
Chronic kidney disease and the FLOW result
Posting this under the heading it deserves: Chronic kidney disease and the FLOW result Everything below is what sits behind that. Chronic kidney disease: setting out the arithmetic in full, because I have had…
|
+34 | 38 | 33k | 23mo |
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since
Posting this under the heading it deserves: Semaglutide half-life: where the 165 to 184 hour figure comes from — what changed since Everything below is what sits behind that. Putting the numbers in the first…
|
+125 | 132 | 39k | 16mo |
|
Follow-up: Sodium, potassium and magnesium when intake drops
On the subject in the title: Sodium, potassium and magnesium when intake drops Working notes rather than a conclusion. A hydration and intake question, with the figures, since this one is unanswerable without…
|
+8 | 12 | 335 | 7mo |
|
The most common factual error about semaglutide on the internet
On the subject in the title: The most common factual error about semaglutide on the internet Working notes rather than a conclusion. Putting the numbers in the first post, because a question about a compound…
|
2 | 49k | 2y | |
|
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile
Posting this under the heading it deserves: Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Everything below is what sits behind that. Semaglutide and gastric emptying,…
|
+115 | 122 | 2.6k | 1d |
|
The C-cell question: rodent findings and their human context — what changed since
The C-cell question: rodent findings and their human context — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of c-cell question…
|
+61 | 65 | 1.3k | 22mo |