Topic summary

Journal club: STEP 8 and the fairness of the comparator dose — a second dataset

Evidence › Journal club risk of bias journal club effect size estimand randomised trial

This is a generated summary. It shows the 5 most-liked posts from a topic of 23, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

j.fonsecaTL220 Apr 2026#6

dr_seong, post #3: Practical answer on STEP 8, since the theoretical one is upthread: do the simplest check first, write down the result, and only then decide whether the complicated explanation is needed. It usually is not. Go to post

I have no financial interest in anything named in this thread and I want to say so before I comment on STEP 8, because it is the sort of subject where it matters.

22 likes in reply to #3 3mo

m.lehtinenTL216 May 2026#10

Sessions on negative or null results are consistently the most instructive and the hardest to get anyone to attend.

30 likes 2mo

s.radichTL222 May 2026#11

o.lindgren, post #1: Posting this under the heading it deserves: Journal club: STEP 8 and the fairness of the comparator dose — a second dataset Everything below is what sits behind that. Posting a small dataset on STEP 8. It is mine, it is uncontrolled, and the method is stated so it can be discounted appropriately. What I would like is not agreement but a… Go to post

No disagreement from me. Posting only so the question does not look ignored.

28 likes in reply to #1 2mo

f.fenwickTL3Regular12 Jul 2026#20

Post #17 answers the question as asked. The question underneath it is different.

Small methodological point on STEP 8: repeating a measurement is cheap and resolves most of what is being argued about here at no cost to anyone.

27 likes 16d

s.coelhoTL222 Jul 2026#22

The baseline characteristics table is the single most useful page for the questions that get asked here, because it tells you who the result applies to.

25 likes 6d

Read the full topic (23 posts)

Suggested topics

Topic	Participants	Replies	Views	Activity
Journal club: LEADER as the historical anchor Evidence › Journal club estimand number needed to treat journal club effect size Pinned Journal club: LEADER as the historical anchor Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of LEADER is wrong? I ask because I have…	+103	110	8.1k	2h
[2026 update] Journal club: PIONEER 6 as a safety trial Evidence › Journal club journal club number needed to treat estimand Journal club: PIONEER 6 as a safety trial Writing it up because I had to work it out twice and would rather nobody else did. Bringing a claim rather than a paper, because the claim is the thing circulating.…	+14	18	55k	5mo
[2026 update] Journal club: SURPASS-2 and the semaglutide 1 mg comparator Evidence › Journal club estimand randomised trial number needed to treat effect size Journal club: SURPASS-2 and the semaglutide 1 mg comparator Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURPASS-2 ( N Engl J Med , 2021). Please read it…	+126	138	31k	17mo
Journal club: the CagriSema phase 2 combination paper — a second dataset Evidence › Journal club journal club estimand effect size Solved Journal club: the CagriSema phase 2 combination paper — a second dataset — setting out what I have, and where I think it stops being reliable. Posting a small dataset on CagriSema phase 2 combination paper.…	+74	79	2.3k	13mo
[2026 update] Journal club: what we got wrong in an earlier session Evidence › Journal club journal club effect size estimand number needed to treat Solved Journal club: what we got wrong in an earlier session — setting out what I have, and where I think it stops being reliable. Bringing a claim rather than a paper, because the claim is the thing circulating.…	+5	9	4.2k	1d

Related topics — sharing the tags risk of bias, journal club, effect size

Topic	Participants	Replies	Views	Activity
Washout with a one-week half-life: the arithmetic Research Methods › N-of-1 designs effect size data table worked example Wiki Washout with a one-week half-life: the arithmetic — setting out what I have, and where I think it stops being reliable. Washout: setting out the arithmetic in full, because I have had to do it twice and I…	+90	96	44k	20mo
Tracking a preprint to publication: a worked example — the long version Evidence › Preprints risk of bias preprint effect size Posting this under the heading it deserves: Tracking a preprint to publication: a worked example — the long version Everything below is what sits behind that. A preprint question rather than a question about…	+38	47	560	22mo
Tirzepatide storage and stability: what is published versus what is assumed Compounds › Tirzepatide SURPASS programme randomised trial SURMOUNT programme effect size On the subject in the title: Tirzepatide storage and stability: what is published versus what is assumed Working notes rather than a conclusion. Asking about tirzepatide storage and stability directly,…	+17	21	17k	12d
Why cagrilintide alone is discussed so much less than in combination — does this still hold? Compounds › Cagrilintide & amylin analogues cagrisema randomised trial cagrilintide effect size Solved Under review Why cagrilintide alone is discussed so much less than in combination — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Cagrilintide alone:…	+27	31	1.2k	22h
Why cagrilintide alone is discussed so much less than in combination Compounds › Cagrilintide & amylin analogues effect size amylin analogues cagrisema Solved Closed Why cagrilintide alone is discussed so much less than in combination I have a specific reason for asking rather than idle curiosity, and the context is below. Collecting what is known about cagrilintide alone…	+93	108	35k	16mo