Topic summary

Lipid changes during rapid weight loss: the expected trajectory

Clinical › Bloodwork liver enzymes thyroid function lipid panel lipase & amylase HbA1c Solved

This is a generated summary. It shows the 5 most-liked posts from a topic of 16, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

a.nascimentoTL2 Solution6 Jun 2026 · edited#3

r.arbuthnot, post #1: Posting this under the heading it deserves: Lipid changes during rapid weight loss: the expected trajectory Everything below is what sits behind that. Lipid changes during rapid weight: what I expected, what I found, and the gap between them. I am posting the gap rather than a theory about it. My theories about gaps like this one have… Go to post

If someone has run lipid changes during rapid weight properly I would rather read that than my own reconstruction of it. Posting mine only because the thread has gone quiet.

11 likes in reply to #1 2mo

d.bramleyTL3Regular11 Jun 2026#4

k.brandl_de, post #2: Answering the question the opening post raises rather than the one it answers. Liver enzyme changes during rapid weight loss are commonly reported and have several possible explanations, which is exactly why they need clinical interpretation rather than forum interpretation. Go to post

Agreed on lipid changes during rapid weight, with one qualification that I think matters. The reasoning holds for the case as described. Change the starting assumption and it does not, and the starting assumption is the part nobody states.

23 likes in reply to #2 2mo

v.kjaerTL216 Jun 2026#5

Renal function markers: eGFR is estimated, not measured. It depends on creatinine, age, and weight. A small change in creatinine might not mean a real change in kidney function.

Not the answer, but possibly the question that gets there.

32 likes 1mo

erratum_fileTL3Regular28 Jun 2026#8

I have no financial interest in anything named in this thread and I want to say so before I comment on lipid changes during rapid weight, because it is the sort of subject where it matters.

17 likes 29d

PharmNotes_WhitfieldTL4Pharmacist21 Jul 2026#14

Taking post #12 at face value and following it one step further.

Lipid changes during substantial weight loss are expected and their trajectory is not always monotonic. A single mid-course panel can be misleading.

30 likes 7d

Read the full topic (16 posts)

This topic was referenced in

Reference intervals: how they are constructed and why one in twenty flagsClinical › Bloodwork · 119 replies
Lipase elevation without symptoms: the interpretation problem — a second datasetClinical › Bloodwork · 15 replies
[2026 update] A single out-of-range value on an otherwise normal panelClinical › Bloodwork · 19 replies

Suggested topics

Topic	Participants	Replies	Views	Activity
Biological variation versus analytical imprecision — does this still hold? Clinical › Bloodwork HbA1c eGFR & renal function thyroid function lipid panel Solved Closed The question in the title: Biological variation versus analytical imprecision — does this still hold? I will give what I have already checked below so nobody repeats it. The question about Biological…		2	1.8k	8mo
Biological variation versus analytical imprecision Clinical › Bloodwork lipase & amylase liver enzymes thyroid function HbA1c On the subject in the title: Biological variation versus analytical imprecision Working notes rather than a conclusion. A question about biological variation versus analytical imprecision that I think has a…		2	42k	12mo
Second pass at: A single out-of-range value on an otherwise normal panel Clinical › Bloodwork thyroid function lipid panel eGFR & renal function lipase & amylase Second pass at: A single out-of-range value on an otherwise normal panel Writing it up because I had to work it out twice and would rather nobody else did. General question, not a request for advice about my…	+9	13	8.5k	16mo
[2026 update] Thyroid function tests during substantial weight change Clinical › Bloodwork eGFR & renal function lipase & amylase HbA1c thyroid function Thyroid function tests during substantial weight change Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of Thyroid function tests during…	+69	74	4.5k	2mo
HbA1c lag and what it can and cannot tell you at eight weeks — one year on Clinical › Bloodwork liver enzymes lipase & amylase lipid panel thyroid function Posting this under the heading it deserves: HbA1c lag and what it can and cannot tell you at eight weeks — one year on Everything below is what sits behind that. A methods question rather than a substantive…	+18	22	655	13h

Related topics — sharing the tags liver enzymes, thyroid function, lipid panel

Topic	Participants	Replies	Views	Activity
[2026 update] Building a sensible monitoring schedule with your prescriber Clinical › Bloodwork thyroid function HbA1c lipid panel lipase & amylase Closed Posting this under the heading it deserves: Building a sensible monitoring schedule with your prescriber Everything below is what sits behind that. Reading back through what has been written here about…	+22	26	5.1k	14mo
[2026 update] Lipid changes during rapid weight loss: the expected trajectory Clinical › Bloodwork thyroid function eGFR & renal function lipid panel lipase & amylase Lipid changes during rapid weight loss: the expected trajectory Writing it up because I had to work it out twice and would rather nobody else did. Lipid changes during rapid weight keeps being re-asked here…	+51	56	7.1k	17mo
Fasting versus non-fasting and which tests care Clinical › Bloodwork eGFR & renal function lipase & amylase HbA1c Solved Fasting versus non-fasting and which tests care Writing it up because I had to work it out twice and would rather nobody else did. Fasting versus non-fasting: what I expected, what I found, and the gap…	+72	78	14k	19h
Lipase elevation without symptoms: the interpretation problem Clinical › Bloodwork thyroid function lipase & amylase eGFR & renal function Pinned Closed Lipase elevation without symptoms: the interpretation problem Writing it up because I had to work it out twice and would rather nobody else did. Lipase elevation without symptoms — I have the observation and…	+21	25	62k	5mo
Reference intervals: how they are constructed and why one in twenty flags Clinical › Bloodwork HbA1c thyroid function eGFR & renal function lipase & amylase Under review Reference intervals: how they are constructed and why one in twenty flags — setting out what I have, and where I think it stops being reliable. Reference intervals: what I expected, what I found, and the gap…	+104	119	30k	1mo