Sensible. I would want the same detail before I acted on it either.
31 likes 12mo
Topic summary
Liver enzymes drifting down and what that usually means
This is a generated summary. It shows the 9 most-liked posts from a topic of 73, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.
p.mwangi, post #7: Nothing to add, except that this is the answer I would give if asked. Go to post
Since liver enzymes drifting keeps coming up, it should probably be a maintained page rather than a recurring thread. I am happy to draft it if someone with more direct experience will review it.
PharmNotes_Whitfield, post #2: This follows the opening post rather than contradicting it. A trend needs at least three points to be a trend. Two points are a line and a line through noise is still a line. Go to post
Fine by me. I had wanted a stronger conclusion and there is not one available.
Reference intervals: constructed to contain the central 95% of a reference population, which means one in twenty healthy people falls outside one by definition. Add biological variation and analytical imprecision and the base rate of a meaningless flag is substantial.
The general answer and the answer for your case may diverge here.
29 likes 9mo
Post #27 is the version of this I will quote in future. One addition.
Small methodological point on liver enzymes drifting: repeating a measurement is cheap and resolves most of what is being argued about here at no cost to anyone.
28 likes 8mo
Liver enzyme changes during rapid weight loss are commonly reported and have several possible explanations, which is exactly why they need clinical interpretation rather than forum interpretation.
The general case is well covered; this is the awkward specific one.
31 likes 8mo
Worth separating two things that post #38 runs together.
Where a panel includes a calculated value, that value inherits the imprecision of everything it was calculated from and is usually reported without an interval.
32 likes 7mo
n.vukovic, post #69: Glycaemic markers integrate over different periods. A point glucose and a longer-term marker disagreeing is not a contradiction; it is two different questions. Go to post
The most useful thing anyone has posted about liver enzymes drifting in this category was a table of what had been measured and by whom. That is what I would want again.
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