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Practice · Administration · continued

Pinch or no pinch, and how needle length changes the answer posts 31–60

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

OL
o.lindgrenTL2Regular24 Aug 2025#31

Post #28 answers the question as asked. The question underneath it is different.

Small methodological point on pinch: repeating a measurement is cheap and resolves most of what is being argued about here at no cost to anyone.

0 likes 11mo
RL
r.lundgrenTL224 Aug 2025#32

I read post #31 twice before replying, because I had assumed the opposite.

Leaving the needle in for a couple of seconds after depressing the plunger reduces leakage at the site. It costs nothing and it is the fix for the "some came back out" question.

It cost nothing to check and would have cost something not to.

1 like 11mo
FP
forest_plotTL3Evidence synthesis25 Aug 2025#33
f.villalobos, post #20: Pinch has a well-known answer and a correct answer, and the interesting work is establishing that they are the same. Nobody has done that here yet. Go to post

I would keep pinch and the decision it usually gets used for separate in this thread. They are related and they are not the same question, and merging them is why the last one went badly.

5 likes in reply to #20 11mo
NC
n.cardosoTL226 Aug 2025#34

No disagreement from me. Posting only so the question does not look ignored.

15 likes 11mo
AK
a.kowalczykTL2Regular27 Aug 2025#35

Pinch is worth one more sentence than it usually gets, and the sentence is the one about how the number was arrived at.

0 likes 11mo
MA
m.almeidaTL227 Aug 2025#36

Everything in post #35 holds. The case it does not cover is the one I have.

If you have to inject at a different time of day than usual, that is a much smaller perturbation than it feels for a weekly compound with a week-long half-life.

I would want to see it done twice before believing it once.

2 likes 11mo
DM
d.moreauTL2Regular28 Aug 2025#37
t.pereira, post #19: Post #18 answers the question as asked. The question underneath it is different. The documentation on pinch is better than this thread and I say that as someone who has posted in the thread. Go to post

Building on post #36 rather than restating it.

Injecting into an area that has become firm: lipohypertrophy — thickened fatty tissue from repeated injection in one area — changes local tissue absorption. Avoid injecting into areas that are noticeably firm or lumpy and allow those areas to recover for at least a few months.

A partial answer, offered because a partial answer beats none.

9 likes in reply to #19 11mo
YI
y.ibarraTL229 Aug 2025#38
integrator_log, post #27: Clear enough that I do not think I have a follow-up, which is unusual. Go to post

An honest declaration on pinch: I have a prior here and it is strong enough that you should weight what I say downward. Stating it rather than hiding it.

21 likes in reply to #27 11mo
JM
j.mwangiTL4 Moderator30 Aug 2025#39

Injection discomfort: comes from needle gauge (finer = less discomfort), volume (smaller = less discomfort), temperature (room temperature or warmed is less uncomfortable than cold), and technique (smooth, purposeful injection is less uncomfortable than hesitant). All four are under your control.

0 likes 11mo
DE
d.eriksenTL230 Aug 2025#40

The strongest argument against my own position on pinch, stated as well as I can state it, since nobody else has yet.

5 likes 11mo
ST
s.teixeiraTL231 Aug 2025#41

Needle length matters less than angle for subcutaneous delivery in most people. A short needle at ninety degrees and a longer one at forty-five put the material in roughly the same place.

25 likes 11mo
K
KAnderssonTL3Regular1 Sep 2025#42

What I would tell a new member reading about pinch for the first time: the confident posts are not the reliable ones, and the reliable ones are longer.

12 likes 11mo
EN
e.ndiayeTL22 Sep 2025#43

On post #39 — agreed on the reasoning, with one qualification.

If you have to inject at a different time of day than usual, that is a much smaller perturbation than it feels for a weekly compound with a week-long half-life.

That is the shape of it. The detail is where I would expect to be corrected.

1 like 11mo
DS
d.szymanskiTL3Wiki editor2 Sep 2025#44
f.fenwick, post #13: Picking up post #10: that is the part I would want checked first. I would be cautious about generalising from the pinch example above. It is a good example. It is one example. Go to post

This follows post #43 rather than contradicting it.

An update on my earlier pinch post: the pattern held for another six weeks and then stopped, which I did not predict and cannot explain.

0 likes in reply to #13 11mo
BC
b.correiaTL23 Sep 2025 · edited#45

Angle of injection: 90 degrees into pinched tissue ensures subcutaneous placement. It is not always necessary and shallower angles can work, but 90 degrees into a small pinch is the safest technique to learn first.

0 likes 11mo
GV
g.valckenaereTL3Regular4 Sep 2025#46

Drawing up with one needle and injecting with another: a reasonable practice if you have extra needles. Fresh needle for injection reduces tissue drag and can decrease discomfort. Not necessary, but not harmful either.

Stating my assumptions rather than smuggling them in.

17 likes 11mo
SD
st.dialloTL24 Sep 2025#47
b.jankowiak, post #29: Post #25 describes the usual case. This is about the unusual one. The reason pinch is hard to answer is that the obvious measurement and the relevant quantity are not the same thing, and substituting one for the other is silent. Go to post

On post #43 — agreed on the reasoning, with one qualification.

Adding a null result on pinch. I looked, carefully, and found nothing, and null results deserve posting precisely because they never are.

4 likes in reply to #29 11mo
H
HHidalgoTL2Member5 Sep 2025#48
t.pereira, post #19: Post #18 answers the question as asked. The question underneath it is different. The documentation on pinch is better than this thread and I say that as someone who has posted in the thread. Go to post

Pinch would be much easier to settle if anyone reported the denominator. Almost nobody reports the denominator.

0 likes in reply to #19 11mo
AJ
a.jansenTL26 Sep 2025#49

If you have to inject at a different time of day than usual, that is a much smaller perturbation than it feels for a weekly compound with a week-long half-life.

Speaking for myself and not for anyone else who has posted here.

0 likes 11mo
MD
m.dalgaardTL3Regular6 Sep 2025#50

Post #47 answers the question as asked. The question underneath it is different.

The single most common technique error described here is drawing to the wrong graduation because the barrel was read at an angle. Read it straight on, at eye level, every time.

Not the whole picture, but the part of it I can speak to.

24 likes 11mo
NL
n.laurentTL27 Sep 2025#51

Confirming post #50 from a second method, which matters more than confirming it from a second person.

What I would want before treating pinch as settled: the method, the sample, and whether anyone tried to find the opposite result. Two of the three are usually missing.

0 likes 11mo
CR
compounding_ruthTL4Pharmacist8 Sep 2025#52

Grateful for the specificity. Vague answers to this question are what sent me looking.

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IN
i.norgaardTL29 Sep 2025#53
k.kimani, post #12: Bleeding at the site is common and unremarkable at these needle gauges. Persistent bruising in the same area repeatedly is worth a change of technique or of site rather than of compound. One case, stated as one case. Go to post

Pinch is well covered in the tag pages, and the older discussions are better than the recent ones because they were argued out properly. Worth twenty minutes before adding to this one.

8 likes in reply to #12 11mo
IT
impurity_tableTL3Analytical chemist9 Sep 2025#54
ma.balogun, post #24: Building on post #21 rather than restating it. Injection discomfort: comes from needle gauge (finer = less discomfort), volume (smaller = less discomfort), temperature (room temperature or warmed is less uncomfortable than cold), and technique (smooth, purposeful injection is less uncomfortable than hesitant). All four are under your… Go to post

Pinching a fold is useful for lean tissue and unnecessary elsewhere. The point is to keep the needle out of muscle, and whether you need to depends on the site and on you.

19 likes in reply to #24 11mo
SO
s.ostergaardTL210 Sep 2025#55
BV
bias_varianceTL4Biostatistician11 Sep 2025#56

Bleeding at the site is common and unremarkable at these needle gauges. Persistent bruising in the same area repeatedly is worth a change of technique or of site rather than of compound.

I would rather be precise about what I do not know than vague about what I do.

0 likes 11mo
MS
m.steinerTL211 Sep 2025#57

Pinch or no pinch: the decision depends on needle length and on your own anatomy. A longer needle (8 mm and up) reaches subcutaneous tissue easily without a pinch. A shorter needle (4-6 mm) is safer with a gentle pinch. The pinch size matters less than people think; the injection angle matters more.

4 likes 11mo
B
batchlogTL3Regular12 Sep 2025 · edited#58
r.lundgren, post #32: I read post #31 twice before replying, because I had assumed the opposite. Leaving the needle in for a couple of seconds after depressing the plunger reduces leakage at the site. It costs nothing and it is the fix for the "some came back out" question. It cost nothing to check and would have cost something not to. Go to post

On post #56 — agreed on the reasoning, with one qualification.

Agreed on pinch, with one qualification that I think matters. The reasoning holds for the case as described. Change the starting assumption and it does not, and the starting assumption is the part nobody states.

13 likes in reply to #32 10mo
VK
v.krastevTL213 Sep 2025#59

Bleeding at the injection site: normal and usually minimal. A little blood at the needle site after withdrawal is not a reason to assume you lost a significant dose. The needle passed through tissue and there is a small amount of bleeding in the tract.

If anyone has run this properly I would rather read that than my own guess.

0 likes 10mo
MA
m.achebeTL213 Sep 2025#60

Injecting into an area that has become firm: lipohypertrophy — thickened fatty tissue from repeated injection in one area — changes local tissue absorption. Avoid injecting into areas that are noticeably firm or lumpy and allow those areas to recover for at least a few months.

Not a strong opinion, just a consistent one.

4 likes 10mo