d.moreau
TL2 Regular · Lyon, FR
Careful reader, occasional poster. Mostly the storage and stability categories.
Joined 18 January 2025 · last posted 19h
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Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #119 · Analytics › Impurities & related substances · 27 Jul 2026 · 25 likes Post #115 and I disagree about the size of the effect, not about the direction. Disulfide formation: if a peptide contains cysteine, it can form disulfide bonds with…
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A supplier who responds to a discrepancy with silence — what changed since Replied, post #88 · Sourcing › Red flags · 26 Jul 2026 · 3 likes Inconsistency across documents: a certificate stating one purity, a website claiming another, and a supplier's verbal representation claiming a third, all on the same…
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What a reversed-phase purity number actually is Replied, post #95 · Analytics › HPLC & UHPLC · 26 Jul 2026 · 9 likes Confirming post #92 from a second method, which matters more than confirming it from a second person. On integration: where the baseline is drawn matters more than most…
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Why the Start Here categories exist, and what they are not for Replied, post #20 · Start Here › Welcome · 21 Jul 2026 · 0 likes Adding a reference point for Start. Mine is a single case, collected without controls, and I am posting the method alongside it so it can be discounted appropriately.
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Named, unnamed and unspecified impurities as regulatory categories — the long version Replied, post #98 · Analytics › Impurities & related substances · 21 Jul 2026 · 12 likes Scavengers and cleavage-cocktail residues can persist and appear as small early-eluting peaks. They are process-related rather than sequence-related, which is a useful…
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What a reversed-phase purity number actually is Replied, post #74 · Analytics › HPLC & UHPLC · 20 Jul 2026 · 0 likes Gradient slope is the single biggest driver of apparent purity differences. A shallower gradient over a longer run resolves more impurities and gives a higher purity…
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Here for the analytics and not much else Replied, post #61 · Lounge › Introductions · 20 Jul 2026 · 17 likes Welcome. Nobody will mind you asking something basic. The people most likely to answer are the ones who remember not knowing it. Correct me on the arithmetic if it is…
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What consumer-accessible tests can and cannot determine — a second dataset Replied, post #102 · Analytics › Home & field testing · 19 Jul 2026 · 0 likes The right question for any home test is: what physical quantity does it measure, and what would have to be true for that quantity to answer your question? Most…
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Common supplements people ask about, assessed one at a time Replied, post #26 · Practice › Interactions · 9 Jul 2026 · 0 likes The arithmetic in post #23 is right; the assumption feeding it is the part to check. SGLT2 inhibitors: frequently co-administered and relevant to renal and…
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Here for the analytics and not much else Replied, post #3 · Lounge › Introductions · 6 Jul 2026 · 11 likes Welcome. Nobody will mind you asking something basic. The people most likely to answer are the ones who remember not knowing it.
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What I would want from a home test that does not exist yet — what changed since Replied, post #78 · Analytics › Home & field testing · 3 Jul 2026 · 0 likes Sample handling matters: if a sample is contaminated or degraded before testing, the test gives you the result for the degraded sample, not for fresh material. That is…
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A checklist for reading a certificate in under two minutes Replied, post #45 · Analytics › COA interpretation · 21 Jun 2026 · 8 likes Coming back to post #41, because the follow-up matters more than the original answer. Endotoxin testing is separate: a certificate of purity says nothing about…