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Devices · Pens & autoinjectors · continued

Second pass at: Pen dose counters: what a click does and does not guarantee posts 31–60

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

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RidgewayTL3Regular2 May 2025#31

Picking up post #29: that is the part I would want checked first.

A pen delivers a fixed or dialled dose from a cartridge and is a metering device rather than simply a covered syringe. That is why dose changes are constrained to whatever the mechanism supports.

21 likes 15mo
ZA
z.adeyemiTL24 May 2025 · edited#32

On post #28 — agreed on the reasoning, with one qualification.

Priming exists because the needle and the cartridge path contain air after a needle change. Skipping it means the first fraction of the dose is not liquid.

0 likes 15mo
EL
endpoint_lineTL3Regular5 May 2025#33

Visibility of the dose: some pens allow you to see the insulin remaining; others do not. Keeping track using the dose counter is important if visibility is limited.

This is where my knowledge stops and I would rather mark the edge than blur it.

2 likes 15mo
SK
s.kravchenkoTL26 May 2025#34
r.aldana_pharmd, post #10: Picking up post #7: that is the part I would want checked first. Needle changes between doses are specified for a reason and the reasons are dose accuracy and sterility rather than comfort alone. Go to post

Pen confusion between compounds: if you are using multiple pens or alternating pens, confirming you have the correct pen before injection prevents administration errors. Check the label every time.

I am describing what is, rather than arguing for what should be.

9 likes in reply to #10 15mo
GF
gradient_fileTL2Member8 May 2025#35

Adding the measurement that post #34 says would settle it.

Storage after first use: most pens can be stored at room temperature after first use, even if unrefrigerated, for a limited time (often 28 days). Check your specific pen's labelling.

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CV
ca.vermeulenTL29 May 2025#36

Following this. I have the same question and no better information than the first post.

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WoodhouseTL2Member10 May 2025#37

Injection duration: most pens deliver the dose over several seconds. Holding the button down for the full duration ensures complete delivery. Releasing early can result in underdosing.

I would want a second opinion before relying on that.

0 likes 15mo
ZV
z.vogelTL212 May 2025#38
a.sorensen, post #15: Pen confusion between compounds: if you are using multiple pens or alternating pens, confirming you have the correct pen before injection prevents administration errors. Check the label every time. If that is already documented somewhere, ignore me and link it. Go to post

Where I part company with post #37, and it is a narrow parting.

Reusability: some pens are single-use (throw away after one injection). Others can be reused until empty. Confirm which type you have. Reusing a single-use pen is ineffective because the mechanism does not reset.

5 likes in reply to #15 15mo
DW
diluent_watchTL2Member13 May 2025#39
z.adeyemi, post #32: On post #28 — agreed on the reasoning, with one qualification. Priming exists because the needle and the cartridge path contain air after a needle change. Skipping it means the first fraction of the dose is not liquid. Go to post

Priming: most pens require priming before the first use (injecting a small amount to fill the needle and line). Not priming can result in no dose being delivered on the first injection.

One case, stated as one case.

10 likes in reply to #32 15mo
ON
o.nybergTL214 May 2025#40

Off-label dosing with a pen: if you want to deliver a dose different from the pen's pre-set steps (e.g., halfway between two step doses), that is off-label use. Some pens allow it; others do not. Confirm before attempting.

Stating my assumptions rather than smuggling them in.

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a.reyesTL4 Admin15 May 2025#41
a.salcedo, post #18: Thank you — that answers what I came here to find out. Go to post

Worth separating two things that post #37 runs together.

The click count on a dialled pen is a mechanical property of that pen and is not a universal unit. Counting clicks across two different devices is not a conversion.

15 likes in reply to #18 14mo
BO
b.oseiTL217 May 2025 · edited#42

This follows post #41 rather than contradicting it.

Holding the pen in place for the stated count after the plunger stops is the manufacturer's answer to leakage at the site. It is on the instruction leaflet and it is the step most often skipped.

I would call that likely rather than established.

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s.leclercTL4 Moderator18 May 2025#43

No notes. Posting so the count is not one.

1 like 14mo
LS
l.salinasTL219 May 2025#44

Comparing cost per milligram between a pen and a vial ignores wastage, dead volume and the number of doses actually obtainable. Cost per delivered dose at your dose is the comparison that survives.

If anyone can point at the primary source I would be grateful.

0 likes 14mo
BS
b.solbergTL220 May 2025#45
b.petrov, post #25: Post #23 put the caveat in the right place and I want to underline it. Disposal of a used pen is a sharps question even where the needle is retracted, and local rules vary more than people expect. That much is documented. The rest is how I have interpreted it. Go to post

On post #41 — agreed on the reasoning, with one qualification.

Needle installation: some pens require a fresh needle for each injection; others have a single needle that stays attached. Check the design of your pen.

I would rather post the uncertainty than round it away.

22 likes in reply to #25 14mo
MC
m.coelhoTL222 May 2025#46

A pen that has been dropped may not be visibly damaged and may not deliver accurately afterwards. Manufacturers say to replace rather than to test, and there is no test a user can do.

The general case is well covered; this is the awkward specific one.

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KR
k.radichTL223 May 2025#47

Needle changes between doses are specified for a reason and the reasons are dose accuracy and sterility rather than comfort alone.

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HM
h.mbekiTL224 May 2025#48
Woodhouse, post #37: Injection duration: most pens deliver the dose over several seconds. Holding the button down for the full duration ensures complete delivery. Releasing early can result in underdosing. I would want a second opinion before relying on that. Go to post

Storage instructions for a pen typically differ before and after first use, and the in-use period is the one people miss. It is on the carton.

0 likes in reply to #37 14mo
SC
sourced_claimsTL3Regular25 May 2025 · edited#49

The residual left in a cartridge at the end is deliberate overfill and is not a dose you are entitled to extract. Attempting to recover it is where accuracy goes.

If anyone has run this properly I would rather read that than my own guess.

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CC
ch.correiaTL227 May 2025#50

I came in to disagree and I am leaving without a disagreement.

1 like 14mo
ET
e.tammTL228 May 2025#51

Adding the measurement that post #48 says would settle it.

A pen taken straight from the refrigerator is uncomfortable to inject for the same reason a cold syringe is. Room temperature for a short while first is the standard advice.

I have changed my mind on this once already, so take it as current rather than settled.

23 likes 14mo
CN
cannula_notesTL2Member29 May 2025#52

Post #51 describes the usual case. This is about the unusual one.

Disposal of a used pen is a sharps question even where the needle is retracted, and local rules vary more than people expect.

If it helps: the failure mode here is usually boring rather than dramatic.

0 likes 14mo
ZN
z.nakamuraTL230 May 2025#53
a.nwosu, post #7: Reusability: some pens are single-use (throw away after one injection). Others can be reused until empty. Confirm which type you have. Reusing a single-use pen is ineffective because the mechanism does not reset. I would put the burden of proof on the interesting explanation, not the dull one. Go to post

Reading the dose window rather than the dial position is worth the habit. On several devices the two do not correspond in the way you would guess.

I looked this up rather than remembered it, which is the right order.

1 like in reply to #7 14mo
EM
e.mikkelsenTL2Member31 May 2025 · edited#54
blank_injection, post #19: A pen taken straight from the refrigerator is uncomfortable to inject for the same reason a cold syringe is. Room temperature for a short while first is the standard advice. Go to post

Travel with a pen raises a cold-chain question and a documentation question. The second is the one people forget until an airport.

7 likes in reply to #19 14mo
TL
t.lindqvistTL21 Jun 2025#55

Bookmarking this. I will come back when I have something worth adding.

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VThorvaldsenTL3Regular3 Jun 2025#56

Answering the question post #54 raises rather than the one it answers.

Nothing here is medical advice, and pen technique is the single easiest thing to have demonstrated in person rather than learned from a description.

The evidence for this is thinner than the way I have phrased it suggests.

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EK
e.krastevTL24 Jun 2025#57
o.vogel, post #2: Nothing here is medical advice, and pen technique is the single easiest thing to have demonstrated in person rather than learned from a description. The confident version of this sentence would be wrong, so here is the hedged one. Go to post

Post #56 is the version of this I will quote in future. One addition.

The instruction leaflet for a licensed pen is a genuinely good technical document and is almost never read past the first page. It answers most of what gets asked here.

It is the sort of thing that seems obvious in retrospect and was not at the time.

3 likes in reply to #2 14mo
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MSaarinenTL35 Jun 2025#58
EK
e.kimaniTL26 Jun 2025#59

Dose counters: pens show the remaining number of doses. When the counter reaches zero, the pen is empty and cannot deliver more. Noting the counter before injection prevents running out unexpectedly.

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PS
p.silvaTL27 Jun 2025#60

Priming: most pens require priming before the first use (injecting a small amount to fill the needle and line). Not priming can result in no dose being delivered on the first injection.

24 likes 14mo