The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of an inactive preparation.
Taste changes and food aversion, reported and discussed posts 31–48
This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1 · go to the accepted answer.
The failure mode on taste changes and food aversion is boring rather than dramatic. It is almost always the step everyone assumes was done correctly because it is too simple to get wrong.
Collapsed as off-topic by two members at trust level 3 or above
Taking post #31 at face value and following it one step further.
Reported effects on taste and on food preference are common and interesting and unstudied in any detail. They are also the ones people find most disconcerting.
I would call that likely rather than established.
Summarising the taste changes and food aversion thread so far, since it is long and the answer is buried: the first reply has the method, the fourth has the correction to it, and the rest is people agreeing at length.
Good question, well framed, and I would like to see it answered properly.
Building on post #35 rather than restating it.
The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of an inactive preparation.
Adding it because I spent an afternoon working it out and nobody should have to twice.
A methods point on taste changes and food aversion rather than a substantive one: if the comparison is not like for like, the difference you are measuring is the difference in method.
Adding the measurement that post #39 says would settle it.
Agreed on taste changes and food aversion, with one qualification that I think matters. The reasoning holds for the case as described. Change the starting assumption and it does not, and the starting assumption is the part nobody states.
Building on post #40 rather than restating it.
The published rates come from populations that were titrated on a defined schedule with clinical supervision. Rates from a forum are not comparable and are biased by who chooses to post.
Not a conclusion. A place to stand while looking for one.
Answering the taste changes and food aversion question as asked, then the question I think is meant. As asked: yes, with the qualification below. As meant: it depends on how the first measurement was taken.
Fatigue: commonly reported, frequently multifactorial. It is worth asking whether other factors have changed (sleep, training volume, diet adequacy, hydration) before attributing all of it to the compound. Some fatigue resolves with time; some persists.
Post #44 is the version of this I will quote in future. One addition.
Constipation is reported at least as often as nausea and is discussed a fraction as much. Fluid, fibre and movement are the boring answers and they are the ones that work.
The general case is well covered; this is the awkward specific one.
The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of an inactive preparation.
Answering the question post #46 raises rather than the one it answers.
Taste changes and food aversion is well covered in the tag pages, and the older discussions are better than the recent ones because they were argued out properly. Worth twenty minutes before adding to this one.
This topic was referenced in
- A side-effect grading scheme this community uses, and its limits — the long versionPractice › Side effects · 23 replies
Suggested topics
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Reflux appearing for the first time at a dose step
Reflux appearing for the first time at a dose step — setting out what I have, and where I think it stops being reliable. Reporting something rather than asking about it, in case the pattern is useful to…
|
4 | 36k | 4mo | |
|
[2026 update] Sulphur-smelling eructation: mechanism and what helps
Posting this under the heading it deserves: Sulphur-smelling eructation: mechanism and what helps Everything below is what sits behind that. I was wrong about Sulphur-smelling eructation in a thread last…
|
2 | 7.3k | 10mo | |
|
Coming back to: Injection-site reactions: describing them precisely enough to be useful
On the subject in the title: Injection-site reactions: describing them precisely enough to be useful Working notes rather than a conclusion. Reading back through what has been written here about…
|
+21 | 25 | 22k | 8mo |
|
Why side effects reset at each escalation and that is not a failure — the long version
The question in the title: Why side effects reset at each escalation and that is not a failure — the long version I will give what I have already checked below so nobody repeats it. A narrow question about…
|
2 | 46k | 17mo | |
|
Revisiting: Early satiety becoming a problem rather than a benefit
On the subject in the title: Revisiting: Early satiety becoming a problem rather than a benefit Working notes rather than a conclusion. Early satiety: setting out the arithmetic in full, because I have had to…
|
2 | 14k | 12mo |
Related topics — sharing the tags fatigue, nausea, hair shedding
| Topic | Participants | Replies | Views | Activity |
|---|---|---|---|---|
|
Second pass at: Programming during a large energy deficit
Posting this under the heading it deserves: Second pass at: Programming during a large energy deficit Everything below is what sits behind that. Two things I would like separated before anyone answers on…
|
+44 | 48 | 632 | 30d |
|
Electrolyte supplements: which ones do anything — a second dataset
Electrolyte supplements: which ones do anything — a second dataset Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on Electrolyte supplements. It is…
|
2 | 59k | 15mo | |
|
A side-effect grading scheme this community uses, and its limits
Posting this under the heading it deserves: A side-effect grading scheme this community uses, and its limits Everything below is what sits behind that. Side-effect grading scheme keeps being re-asked here and…
|
+1 | 5 | 3.8k | 12mo |
|
Coming back to: Delayed gastric emptying and oral medication absorption: which drugs matter
Delayed gastric emptying and oral medication absorption: which drugs matter Writing it up because I had to work it out twice and would rather nobody else did. Reading back through what has been written here…
|
+63 | 74 | 11k | 1d |
|
Sulphur-smelling eructation: mechanism and what helps
Sulphur-smelling eructation: mechanism and what helps — setting out what I have, and where I think it stops being reliable. I would like to disagree carefully with the settled view on sulphur-smelling…
|
2 | 58 | 1d |