Tags · Technique
system suitability
The injections that establish whether a run was valid at all.
Related in this group: HPLC · LC-MS · high-resolution MS · MALDI-TOF · UV & DAD detection · peak integration · gradient method · water content · amino acid analysis · ELISA · endotoxin testing · sterility testing
47 topics · page 2 of 2
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Theoretical plates: useful number or ritual?
Theoretical plates: useful number or ritual? I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about theoretical plates directly, because I have read four…
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2 | 284 | 9mo | |
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Coming back to: Where the integrator drew the baseline, and how much it moved the number
On the subject in the title: Where the integrator drew the baseline, and how much it moved the number Working notes rather than a conclusion. Posting the method first, because I know what the first three…
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+20 | 24 | 2.7k | 10mo |
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An inter-laboratory comparison on one lot, tabulated
On the subject in the title: An inter-laboratory comparison on one lot, tabulated Working notes rather than a conclusion. Collecting what is known about inter-laboratory comparison in one place, because it is…
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3 | 17k | 10mo | |
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Revisiting: Why I ask for the gradient before I discuss the number
Posting this under the heading it deserves: Revisiting: Why I ask for the gradient before I discuss the number Everything below is what sits behind that. I would like to understand what this number means…
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+15 | 19 | 43k | 10mo |
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Column chemistry choices for a 40-residue peptide
Column chemistry choices for a 40-residue peptide — setting out what I have, and where I think it stops being reliable. Collecting what is known about column chemistry choices in one place, because it is…
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+39 | 43 | 1.1k | 10mo |
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Second pass at: LOD and LOQ: definitions people get wrong
Posting this under the heading it deserves: Second pass at: LOD and LOQ: definitions people get wrong Everything below is what sits behind that. Something about LOD and LOQ does not reconcile and I would like…
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+47 | 51 | 40k | 10mo |
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Second pass at: What a reversed-phase purity number actually is
On the subject in the title: Second pass at: What a reversed-phase purity number actually is Working notes rather than a conclusion. I would like to understand what this number means before I repeat it…
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2 | 7.4k | 11mo | |
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Forced degradation studies: designing one that is informative — does this still hold?
The question in the title: Forced degradation studies: designing one that is informative — does this still hold? I will give what I have already checked below so nobody repeats it. The question about Forced…
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+37 | 41 | 1.2k | 12mo |
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Reading a chromatogram someone posted without axes
Reading a chromatogram someone posted without axes — setting out what I have, and where I think it stops being reliable. Posting a small dataset on reading a chromatogram. It is mine, it is uncontrolled, and…
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+47 | 55 | 9.4k | 13mo |
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Repeatability versus intermediate precision
Repeatability versus intermediate precision — setting out what I have, and where I think it stops being reliable. Trying to establish the boundary conditions on repeatability versus intermediate precision.…
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+119 | 134 | 34k | 13mo |
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Relative retention time as a better inter-laboratory comparator
On the subject in the title: Relative retention time as a better inter-laboratory comparator Working notes rather than a conclusion. What changes if the standard account of relative retention time is wrong? I…
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+7 | 11 | 28k | 14mo |
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When to suspect the method rather than the sample
When to suspect the method rather than the sample — that is the question, and I have not found it answered plainly anywhere I have looked. Two reports on the same lot, and I would like help deciding whether…
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+109 | 115 | 63k | 15mo |
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Carryover and the ghost peak from last week's standard
On the subject in the title: Carryover and the ghost peak from last week's standard Working notes rather than a conclusion. What changes if the standard account of carryover is wrong? I ask because I have…
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+80 | 92 | 16k | 16mo |
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Coming back to: Column chemistry choices for a 40-residue peptide
On the subject in the title: Column chemistry choices for a 40-residue peptide Working notes rather than a conclusion. Column chemistry choices — I have the observation and I do not trust my interpretation of…
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2 | 43k | 16mo | |
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Validating a method you did not develop — does this still hold?
Validating a method you did not develop — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Validating a method, and specifically the version of…
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+128 | 148 | 47k | 16mo |
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What a stability-indicating method is and how you demonstrate one — one year on
What a stability-indicating method is and how you demonstrate one — one year on I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about stability-indicating…
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+100 | 112 | 15k | 19mo |
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Why I ask for the gradient before I discuss the number
The question in the title: Why I ask for the gradient before I discuss the number I will give what I have already checked below so nobody repeats it. I would like to understand what this number means before I…
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+35 | 39 | 4.9k | 20mo |