j.lokken
TL2 · Wrocław
Contributes reviews on supplier material. Based in Wrocław.
Joined 3 February 2025 · last posted 2d
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[2026 update] Documenting an adverse event properly Replied, post #22 · Safety › Adverse events · 26 Jul 2026 · 13 likes I have three months of notes on Documenting an adverse event and the honest summary is that the trend is real and the week-to-week numbers are noise. I nearly drew the…
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eGFR fluctuation and the creatinine denominator problem — the long version Replied, post #26 · Clinical › Bloodwork · 22 Jul 2026 · 0 likes Glycaemic markers integrate over different periods. A point glucose and a longer-term marker disagreeing is not a contradiction; it is two different questions. Worth…
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A calculator that gives a right answer to the wrong question Replied, post #35 · Data & Tools › Calculators · 18 Jul 2026 · 0 likes Unit-conversion tools are only as good as the assumption they make about the syringe. Ask what barrel and what graduation interval it assumed before trusting the units…
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Forced degradation studies: designing one that is informative Replied, post #97 · Analytics › Method validation · 13 Jul 2026 · 30 likes Post #93 describes the usual case. This is about the unusual one. Forced degradation studies is well covered in the tag pages, and the older discussions are better than…
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Coming back to: Where the four-week escalation interval comes from, and what it is not Replied, post #19 · Practice › Dosing & titration · 9 Jul 2026 · 0 likes That is consistent with mine, for whatever one more account is worth.
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Follow-up: Sleep quality changes during weight loss Replied, post #65 · Wellbeing › Sleep · 9 Jul 2026 · 19 likes Sensible. I would want the same detail before I acted on it either.
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Electrolyte supplements: which ones do anything Replied, post #46 · Nutrition & Training › Hydration & electrolytes · 3 Jul 2026 · 0 likes Post #44 describes the usual case. This is about the unusual one. The interaction between electrolyte handling and other medicines is a pharmacist question and is…
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Revisiting: What pooling buys you and what it destroys Replied, post #76 · Evidence › Meta-analyses · 2 Jul 2026 · 11 likes The arithmetic in post #75 is right; the assumption feeding it is the part to check. Study quality and weighting: some meta-analyses weight all studies equally; others…
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Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #85 · Compounds › Semaglutide · 30 Jun 2026 · 8 likes Albumin binding is not a unique structural feature and nothing in the class lacks it, but the reversibility matters. Semaglutide binds albumin covalently through a…
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Why this subcategory is stricter about sourcing than most Replied, post #41 · Compounds › Secretagogues & GH axis · 10 Jun 2026 · 0 likes Reconstitution volumes in this family are often small enough that dead volume in the syringe is a meaningful fraction of the dose. A fixed-needle insulin syringe is…
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Revisiting: Mean kinetic temperature explained without the mathematics Replied, post #36 · Practice › Storage & stability · 31 May 2026 · 18 likes Clarity is a weak test. A solution can lose a significant fraction of its active content to degradation or adsorption while remaining perfectly clear. That is one…
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[2026 update] Waist circumference technique and its repeatability Replied, post #13 · Outcomes › Progress reports · 30 May 2026 · 0 likes A single scale used throughout beats a more accurate scale introduced halfway through. Consistency beats accuracy for a trend.