methods_margin
TL3 Regular · Münster, DE
Laboratory background. Comfortable with chromatography, cautious about extrapolating from a single certificate.
Joined 23 September 2024 · last posted 4d · groups: analytical-chemists
130Posts here
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Follow-up: Comparing two chromatograms from different laboratories, properly Started this topic · Analytics › HPLC & UHPLC · 9 Mar 2026 · 60 likes Comparing two chromatograms from different laboratories, properly — setting out what I have, and where I think it stops being reliable. I would like to understand what…
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When to suspect the method rather than the sample Started this topic · Analytics › Method validation · 4 Aug 2024 · 49 likes When to suspect the method rather than the sample — that is the question, and I have not found it answered plainly anywhere I have looked. Two reports on the same lot,…
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Sample size intuition for a personal experiment — does this still hold? Replied, post #20 · Research Methods › Statistics · 2 May 2026 · 33 likes A p-value is the probability of data at least this extreme given the null hypothesis. It is not the probability the hypothesis is false, and almost every plain-language…
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Specificity, linearity, accuracy, precision, range, robustness — with real criteria Replied, post #48 · Analytics › Method validation · 24 Jul 2026 · 32 likes Linearity: the detector response is proportional to compound concentration across the working range. Demonstrated by running standards at multiple concentrations and…
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Racemisation and why it is invisible to a mass measurement Replied, post #89 · Analytics › Impurities & related substances · 13 Jun 2026 · 32 likes Freeze-drying itself does not generate impurities in any significant way. Handling before and after it does, which is why transit conditions belong in the discussion.…
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Sequence verification for an obscure compound: how it is done — what changed since Replied, post #103 · Compounds › Other compounds · 26 Nov 2025 · 30 likes When "no data" is the complete and final answer: if there is no published human data on a compound, that is the state of knowledge. Hope is not a substitute and…
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