20 categories

Evidence

Published evidence, read closely. Trial digests, journal club, meta-analyses, preprints, and structured critique.

148 topics7,629 posts42 solved Moderators: s.leclerc, dr_okonkwo About this category

Trials 33 Journal club 47 Meta-analyses 24 Preprints 20 Study critique 24

148 topics · page 5 of 5

Topic	Participants	Replies	Views	Activity
A well-designed study with a badly written abstract Evidence › Study critique disputed effect size risk of bias observational data Posting this under the heading it deserves: A well-designed study with a badly written abstract Everything below is what sits behind that. Reading back through what has been written here about well-designed…	+117	128	7.2k	14mo
Reading a trial's population section before its results — does this still hold? Evidence › Trials randomised trial open label intention to treat discontinuation & dropout Closed Reading a trial's population section before its results — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Reading STEP 1 ( N Engl J Med , 2021)…	+140	154	5.4k	14mo
Critiquing an observational claim about a class effect Evidence › Study critique disputed risk of bias effect size observational data Posting this under the heading it deserves: Critiquing an observational claim about a class effect Everything below is what sits behind that. I was wrong about critiquing an observational claim in a thread…		2	6.9k	14mo
Coming back to: A critique that turned out to be unfair, retracted by its author Evidence › Study critique disputed observational data effect size confounding Closed A critique that turned out to be unfair, retracted by its author — setting out what I have, and where I think it stops being reliable. Reading back through what has been written here about critique, three…		2	1.3k	14mo
Adjudicated events and why the definition matters — the long version Evidence › Trials intention to treat estimand randomised trial discontinuation & dropout Adjudicated events and why the definition matters — the long version Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about Adjudicated events, deliberately…	+125	146	13k	15mo
Criticising the method without criticising the authors Evidence › Study critique disputed observational data confounding effect size Criticising the method without criticising the authors Writing it up because I had to work it out twice and would rather nobody else did. I was wrong about criticising the method without criticising in a…	+55	61	60k	15mo
Journal club: STEP 4 and what a withdrawal design can prove — one year on Evidence › Journal club number needed to treat estimand randomised trial effect size Closed Journal club: STEP 4 and what a withdrawal design can prove — one year on Writing it up because I had to work it out twice and would rather nobody else did. Session topic: STEP 4 ( JAMA , 2021). Please read…	+56	62	34k	15mo
Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Evidence › Journal club risk of bias number needed to treat randomised trial Asking directly, because I could not find a straight answer: Journal club: STEP 1 and the treatment-policy estimand — does this still hold? Working notes on STEP 1 rather than a conclusion. I would rather…	+118	132	12k	15mo
Follow-up: Journal club: the retatrutide phase 2 obesity paper Evidence › Journal club randomised trial risk of bias effect size journal club Closed On the subject in the title: Journal club: the retatrutide phase 2 obesity paper Working notes rather than a conclusion. A follow-up question about retatrutide phase 2 obesity paper that I did not know to ask…	+20	24	8.7k	16mo
Follow-up: Open-label extensions: what survives and what does not Evidence › Trials open label intention to treat surrogate endpoints estimand Solved Open-label extensions: what survives and what does not — setting out what I have, and where I think it stops being reliable. I have spent a fortnight trying to pin Open-label extensions down and I want to set…	+22	26	397	16mo
Journal club: SUSTAIN 6 and its retinopathy signal — does this still hold? Evidence › Journal club journal club effect size number needed to treat randomised trial The question in the title: Journal club: SUSTAIN 6 and its retinopathy signal — does this still hold? I will give what I have already checked below so nobody repeats it. Reading SUSTAIN 6 ( N Engl J Med ,…	+60	66	12k	16mo
Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Evidence › Journal club randomised trial effect size journal club risk of bias Solved Posting this under the heading it deserves: Journal club: SURMOUNT-OSA and a hard endpoint in a soft field Everything below is what sits behind that. Collecting what is known about SURMOUNT-OSA in one place,…	+47	51	617	16mo
[2026 update] Journal club: SURPASS-2 and the semaglutide 1 mg comparator Evidence › Journal club estimand randomised trial number needed to treat effect size Journal club: SURPASS-2 and the semaglutide 1 mg comparator Writing it up because I had to work it out twice and would rather nobody else did. Session topic: SURPASS-2 ( N Engl J Med , 2021). Please read it…	+126	138	31k	17mo
Coming back to: Reading a meta-analysis you disagree with, fairly Evidence › Meta-analyses meta-analysis publication bias heterogeneity risk of bias Reading a meta-analysis you disagree with, fairly Writing it up because I had to work it out twice and would rather nobody else did. Reading a meta-analysis — I have the observation and I do not trust my…	+30	34	9.3k	17mo
Reading a supplementary appendix and finding the interesting part Evidence › Trials open label discontinuation & dropout intention to treat estimand Reading a supplementary appendix and finding the interesting part — setting out what I have, and where I think it stops being reliable. Collecting what is known about reading a supplementary appendix in one…	+87	92	1.1k	17mo
Random versus fixed effects: choosing rather than defaulting — a second dataset Evidence › Meta-analyses heterogeneity risk of bias publication bias On the subject in the title: Random versus fixed effects: choosing rather than defaulting — a second dataset Working notes rather than a conclusion. Posting a small dataset on Random versus fixed effects. It…	+95	106	20k	17mo
A claim built entirely on a subgroup analysis — what changed since Evidence › Study critique disputed effect size observational data risk of bias Closed On the subject in the title: A claim built entirely on a subgroup analysis — what changed since Working notes rather than a conclusion. What changes if the standard account of claim built is wrong? I ask…		2	2k	18mo
Follow-up: Individual participant data versus aggregate data Evidence › Meta-analyses meta-analysis effect size publication bias heterogeneity Individual participant data versus aggregate data — setting out what I have, and where I think it stops being reliable. A follow-up question about Individual participant data versus aggregate that I did not…	+101	111	23k	18mo
[2026 update] How to read a forest plot, properly, from scratch Evidence › Trials estimand discontinuation & dropout surrogate endpoints Solved How to read a forest plot, properly, from scratch — that is the question, and I have not found it answered plainly anywhere I have looked. Reading SURMOUNT-4 ( JAMA , 2024) for the population rather than the…	+49	53	643	19mo
A well-designed study with a badly written abstract — does this still hold? Evidence › Study critique disputed confounding risk of bias Solved Closed A well-designed study with a badly written abstract — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. Asking about well-designed study on behalf…		2	28k	20mo
Journal club: SURPASS-2 and the semaglutide 1 mg comparator Evidence › Journal club estimand effect size risk of bias journal club Solved On the subject in the title: Journal club: SURPASS-2 and the semaglutide 1 mg comparator Working notes rather than a conclusion. Session topic: SURPASS-2 ( N Engl J Med , 2021). Please read it before posting;…	+71	76	52k	21mo
Tracking a preprint to publication: a worked example — the long version Evidence › Preprints risk of bias preprint effect size Posting this under the heading it deserves: Tracking a preprint to publication: a worked example — the long version Everything below is what sits behind that. A preprint question rather than a question about…	+38	47	560	22mo
Coming back to: Prediction intervals and why they are more honest than confidence intervals Evidence › Meta-analyses publication bias heterogeneity effect size risk of bias Prediction intervals and why they are more honest than confidence intervals Writing it up because I had to work it out twice and would rather nobody else did. Prediction intervals — I have the observation and…		2	65	22mo
Why a preprint's supplementary material is often the best part Evidence › Preprints needs a source risk of bias preprint effect size Why a preprint's supplementary material is often the best part I have a specific reason for asking rather than idle curiosity, and the context is below. A question about how this site should cite something…	+38	42	863	22mo
Reading a meta-analysis you disagree with, fairly Evidence › Meta-analyses heterogeneity risk of bias effect size publication bias Posting this under the heading it deserves: Reading a meta-analysis you disagree with, fairly Everything below is what sits behind that. I would like to disagree carefully with the settled view on reading a…	+7	13	2.5k	23mo
Second pass at: Journal club: LEADER as the historical anchor Evidence › Journal club randomised trial journal club effect size estimand Posting this under the heading it deserves: Second pass at: Journal club: LEADER as the historical anchor Everything below is what sits behind that. Two things I would like separated before anyone answers on…	+75	81	2k	2y
How this community labels and discusses unrefereed work Evidence › Preprints risk of bias effect size preprint needs a source How this community labels and discusses unrefereed work — that is the question, and I have not found it answered plainly anywhere I have looked. Reading an unrefereed manuscript properly, and asking whether I…	+112	119	1.3k	2y
Journal club: FLOW and the renal composite, component by component Evidence › Journal club randomised trial estimand risk of bias On the subject in the title: Journal club: FLOW and the renal composite, component by component Working notes rather than a conclusion. Reading FLOW ( N Engl J Med , 2024) for the population rather than the…	+84	91	18k	2y