20 categories

Evidence

Published evidence, read closely. Trial digests, journal club, meta-analyses, preprints, and structured critique.

148 topics7,629 posts42 solved Moderators: s.leclerc, dr_okonkwo About this category

Trials 33 Journal club 47 Meta-analyses 24 Preprints 20 Study critique 24

148 topics · page 3 of 5

Topic	Participants	Replies	Views	Activity
Journal club: SURMOUNT-4 and continuation versus withdrawal Evidence › Journal club journal club number needed to treat effect size Journal club: SURMOUNT-4 and continuation versus withdrawal — setting out what I have, and where I think it stops being reliable. Trying to establish the boundary conditions on SURMOUNT-4 and continuation…	+32	36	31k	3mo
Open-label extensions: what survives and what does not Evidence › Trials discontinuation & dropout randomised trial estimand Closed Posting this under the heading it deserves: Open-label extensions: what survives and what does not Everything below is what sits behind that. I have spent a fortnight trying to pin open-label extensions down…		4	22k	3mo
Second pass at: What pooling buys you and what it destroys Evidence › Meta-analyses risk of bias meta-analysis heterogeneity Posting this under the heading it deserves: Second pass at: What pooling buys you and what it destroys Everything below is what sits behind that. Something about pooling buys does not reconcile and I would…	+32	36	19k	4mo
Prediction intervals and why they are more honest than confidence intervals Evidence › Meta-analyses heterogeneity risk of bias effect size publication bias Solved Closed Posting this under the heading it deserves: Prediction intervals and why they are more honest than confidence intervals Everything below is what sits behind that. I have spent a fortnight trying to pin…	+21	25	46k	4mo
Preprint servers and what screening they do — the long version Evidence › Preprints risk of bias effect size needs a source On the subject in the title: Preprint servers and what screening they do — the long version Working notes rather than a conclusion. A preprint question rather than a question about the finding in it. The…	+7	11	26k	4mo
Preprint servers and what screening they do Evidence › Preprints preprint effect size needs a source Preprint servers and what screening they do — setting out what I have, and where I think it stops being reliable. A preprint question rather than a question about the finding in it. The manuscript is on a…	+95	106	5.6k	4mo
Run-in periods and the population they select — the long version Evidence › Trials randomised trial estimand intention to treat surrogate endpoints Run-in periods and the population they select — the long version Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about Run-in periods, deliberately narrow,…		2	8.9k	4mo
Journal club: PIONEER 6 as a safety trial Evidence › Journal club effect size journal club number needed to treat risk of bias Posting this under the heading it deserves: Journal club: PIONEER 6 as a safety trial Everything below is what sits behind that. Reading PIONEER 6 ( N Engl J Med , 2019) for the population rather than the…	+14	18	262	5mo
[2026 update] Confounding by indication, explained with a concrete example Evidence › Study critique observational data disputed risk of bias Confounding by indication, explained with a concrete example Writing it up because I had to work it out twice and would rather nobody else did. I have seen SURPASS-4 ( Lancet , 2021) cited in support of a…	+103	116	22k	5mo
[2026 update] Journal club: PIONEER 6 as a safety trial Evidence › Journal club journal club number needed to treat estimand Journal club: PIONEER 6 as a safety trial Writing it up because I had to work it out twice and would rather nobody else did. Bringing a claim rather than a paper, because the claim is the thing circulating.…	+14	18	55k	5mo
Measurement error in a self-reported exposure Evidence › Study critique confounding risk of bias effect size disputed Solved Closed Posting this under the heading it deserves: Measurement error in a self-reported exposure Everything below is what sits behind that. The question about measurement error that I actually want answered is the…	+117	129	45k	5mo
Non-inferiority margins: how they are chosen and how they are abused — a second dataset Evidence › Trials randomised trial discontinuation & dropout intention to treat estimand Non-inferiority margins: how they are chosen and how they are abused — a second dataset — setting out what I have, and where I think it stops being reliable. Posting a small dataset on Non-inferiority…	+32	37	574	5mo
[2026 update] Reading a supplementary appendix and finding the interesting part Evidence › Trials estimand intention to treat open label surrogate endpoints On the subject in the title: Reading a supplementary appendix and finding the interesting part Working notes rather than a conclusion. Collecting what is known about Reading a supplementary appendix in one…	+39	44	8.2k	5mo
Non-inferiority margins: how they are chosen and how they are abused Evidence › Trials open label surrogate endpoints estimand intention to treat Posting this under the heading it deserves: Non-inferiority margins: how they are chosen and how they are abused Everything below is what sits behind that. A question about non-inferiority margins that I…	+42	46	10k	5mo
Heterogeneity as information rather than as a nuisance Evidence › Meta-analyses heterogeneity risk of bias meta-analysis effect size Posting this under the heading it deserves: Heterogeneity as information rather than as a nuisance Everything below is what sits behind that. An honest uncertainty about heterogeneity rather than a disguised…	+88	95	1.2k	6mo
Journal club: semaglutide in MASH, and surrogate endpoints — does this still hold? Evidence › Journal club estimand randomised trial number needed to treat effect size Solved Closed Journal club: semaglutide in MASH, and surrogate endpoints — does this still hold? I have a specific reason for asking rather than idle curiosity, and the context is below. A narrow question about semaglutide…		3	28k	6mo
Sample size calculations, read backwards from the published number Evidence › Trials intention to treat surrogate endpoints randomised trial Sample size calculations, read backwards from the published number Writing it up because I had to work it out twice and would rather nobody else did. Asking about sample size calculations directly, because I…		2	8.1k	6mo
How to read a forest plot, properly, from scratch Evidence › Trials randomised trial intention to treat surrogate endpoints estimand Solved The question in the title: How to read a forest plot, properly, from scratch I will give what I have already checked below so nobody repeats it. Reading STEP 4 ( JAMA , 2021) for the population rather than…	+73	81	17k	7mo
Reverse causation in a cohort study of weight and outcome Evidence › Study critique disputed observational data effect size On the subject in the title: Reverse causation in a cohort study of weight and outcome Working notes rather than a conclusion. Posting a small dataset on reverse causation. It is mine, it is uncontrolled, and…	+10	14	11k	7mo
Journal club: the retatrutide phase 2 obesity paper Evidence › Journal club estimand number needed to treat journal club randomised trial Solved Journal club: the retatrutide phase 2 obesity paper — setting out what I have, and where I think it stops being reliable. Collecting what is known about retatrutide phase 2 obesity paper in one place, because…	+7	11	33k	7mo
Selection into a registry and what it does to the estimate Evidence › Study critique risk of bias disputed observational data Selection into a registry and what it does to the estimate — setting out what I have, and where I think it stops being reliable. Working notes on selection rather than a conclusion. I would rather post the…		2	55k	7mo
[2026 update] Conference abstracts as evidence: the weakest common citation Evidence › Preprints needs a source effect size preprint risk of bias Closed Conference abstracts as evidence: the weakest common citation — setting out what I have, and where I think it stops being reliable. Reading an unrefereed manuscript properly, and asking whether I am doing it…		2	48k	7mo
Tracking a preprint to publication: a worked example Evidence › Preprints preprint risk of bias needs a source Tracking a preprint to publication: a worked example Writing it up because I had to work it out twice and would rather nobody else did. A preprint question rather than a question about the finding in it. The…	+133	147	15k	7mo
Pooling trials with different estimands — what changed since Evidence › Meta-analyses publication bias risk of bias meta-analysis effect size Pooling trials with different estimands — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Pooling trials with different…	+57	64	12k	7mo
What pooling buys you and what it destroys Evidence › Meta-analyses publication bias risk of bias meta-analysis heterogeneity Solved The question in the title: What pooling buys you and what it destroys I will give what I have already checked below so nobody repeats it. The question about pooling buys that I actually want answered is the…	+74	83	6.6k	8mo
A preprint whose numbers changed substantially at publication — what changed since Evidence › Preprints risk of bias effect size needs a source On the subject in the title: A preprint whose numbers changed substantially at publication — what changed since Working notes rather than a conclusion. A preprint question rather than a question about the…	+3	7	125	8mo
Journal club: how we handle discontinuation in obesity trials — what changed since Evidence › Journal club number needed to treat estimand risk of bias randomised trial Solved Journal club: how we handle discontinuation in obesity trials — what changed since — setting out what I have, and where I think it stops being reliable. Session topic: STEP 4 ( JAMA , 2021). Please read it…	+14	18	35k	8mo
Second pass at: Journal club: STEP 4 and what a withdrawal design can prove Evidence › Journal club number needed to treat risk of bias journal club effect size Second pass at: Journal club: STEP 4 and what a withdrawal design can prove Writing it up because I had to work it out twice and would rather nobody else did. The question about STEP 4 that I actually want…	+81	90	54k	9mo
Journal club: indirect comparison between two programmes, defended and attacked — one year on Evidence › Journal club randomised trial risk of bias effect size estimand Posting this under the heading it deserves: Journal club: indirect comparison between two programmes, defended and attacked — one year on Everything below is what sits behind that. Asking about indirect…	+45	50	3k	9mo
Conference abstracts as evidence: the weakest common citation Evidence › Preprints risk of bias effect size needs a source On the subject in the title: Conference abstracts as evidence: the weakest common citation Working notes rather than a conclusion. Reading an unrefereed manuscript properly, and asking whether I am doing it…	+1	5	2k	9mo