Topic summary

Coming back to: Half-life, steady state, and accumulation worked through

Pharmacology › Pharmacokinetics tirzepatide liraglutide worked example semaglutide

This is a generated summary. It shows the 5 most-liked posts from a topic of 19, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.

s.dziedzicTL27 Apr 2026 · edited#8

Washout after stopping takes roughly the same four to five half-lives as reaching steady state. A month after the last dose is not the same as none.

I checked the source rather than the summary, and they differ.

18 likes 4mo

compounding_ruthTL4Pharmacist8 Apr 2026 · edited#9

Half-life: semaglutide ≈ 165–184 hours (about a week). Tirzepatide ≈ 5 days. Liraglutide ≈ 13 hours. The half-life determines how much accumulation happens at steady state and how long it takes to clear after stopping.

Nothing above should be read as advice about what anyone else should do.

19 likes 4mo

ma.balogunTL210 Apr 2026#11

a.silva, post #3: A pharmacokinetic model fitted to trial data describes the population studied. Applying it to somebody outside the enrolled range is an extrapolation, and the model will not tell you it is. Where I would look next, rather than where I would stop. Go to post

Post #7 describes the usual case. This is about the unusual one.

What I can speak to on Half-life is narrow, so I will keep it narrow rather than generalising from it. Beyond that boundary I do not know.

22 likes in reply to #3 4mo

d.nilsenTL213 Apr 2026#15

va.baptista, post #6: Everything in post #4 holds. The case it does not cover is the one I have. A note on how Half-life gets discussed rather than on Half-life itself: the confident posts get the replies and the careful ones get ignored, and the careful ones have been right more often. Go to post

No notes. Posting so the count is not one.

16 likes in reply to #6 3mo

OTeixeiraTL3Regular16 Apr 2026#18

Genuine question rather than a rhetorical one: has anyone here actually observed Half-life, as opposed to read about it? The thread is long and I cannot tell.

31 likes 3mo

Read the full topic (19 posts)

This topic was referenced in

Coming back to: Washout: how long is long enough, and for what purposePharmacology › Pharmacokinetics · 139 replies

Suggested topics

Topic	Participants	Replies	Views	Activity
Half-life, steady state, and accumulation worked through Pharmacology › Pharmacokinetics semaglutide liraglutide tirzepatide Wiki Half-life, steady state, and accumulation worked through Writing it up because I had to work it out twice and would rather nobody else did. Working through the kinetics rather than the pharmacology, because I…	+115	130	44k	13mo
Peak-to-trough ratio at steady state for a weekly agent — the long version Pharmacology › Pharmacokinetics semaglutide missed dose tirzepatide worked example Under review Peak-to-trough ratio at steady state for a weekly agent — the long version Writing it up because I had to work it out twice and would rather nobody else did. A narrow question about Peak-to-trough ratio,…	+57	61	708	1d
Clearance pathways and what renal impairment changes Pharmacology › Pharmacokinetics missed dose liraglutide tirzepatide worked example Clearance pathways and what renal impairment changes Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of clearance pathways is wrong? I…	+11	15	43k	2mo
Half-life, steady state, and accumulation worked through — a second dataset Pharmacology › Pharmacokinetics semaglutide worked example liraglutide Half-life, steady state, and accumulation worked through — a second dataset — setting out what I have, and where I think it stops being reliable. Working through the kinetics rather than the pharmacology,…	+110	126	14k	4mo
Second pass at: Albumin binding and how it produces a long half-life Pharmacology › Pharmacokinetics missed dose worked example semaglutide Posting this under the heading it deserves: Second pass at: Albumin binding and how it produces a long half-life Everything below is what sits behind that. A narrow question about Albumin binding,…	+7	11	31k	17mo

Related topics — sharing the tags tirzepatide, liraglutide, worked example

Topic	Participants	Replies	Views	Activity
Designing a personal experiment that could change your mind Research Methods › N-of-1 designs confounding worked example data table effect size Posting this under the heading it deserves: Designing a personal experiment that could change your mind Everything below is what sits behind that. I was wrong about designing a personal experiment in a thread…	+2	6	695	6mo
[2026 update] Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA Compounds › Tirzepatide tirzepatide effect size randomised trial Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA — setting out what I have, and where I think it stops being reliable. Reading back through what has been written here about Tirzepatide in…		2	58k	11mo
Tracking semaglutide's approved indications across jurisdictions, dated Compounds › Semaglutide semaglutide effect size SELECT trial Tracking semaglutide's approved indications across jurisdictions, dated Writing it up because I had to work it out twice and would rather nobody else did. Putting the numbers in the first post, because a…	+15	19	2.8k	1d
SURMOUNT-4 and what withdrawal data does and does not tell an individual Compounds › Tirzepatide SURPASS programme randomised trial effect size SURMOUNT programme Solved SURMOUNT-4 and what withdrawal data does and does not tell an individual — setting out what I have, and where I think it stops being reliable. I would like to disagree carefully with the settled view on…		4	42k	11mo
Second pass at: Absence of evidence and evidence of absence Research Methods › Statistics worked example confounding number needed to treat On the subject in the title: Second pass at: Absence of evidence and evidence of absence Working notes rather than a conclusion. Two things I would like separated before anyone answers on Absence of evidence,…	+50	55	18k	16h