On the subject in the title: Comparing the STEP programme populations: who was actually enrolled — the long version Working notes rather than a conclusion.
A narrow question about Comparing the STEP programme populations, deliberately narrow, because the broad version has been asked here four times and produced four long threads and no answer.
One question, stated units, stated method, and what I have already ruled out.
The opening post is right about the mechanism and I think understates the practical bit.
Cardiovascular data in people without diabetes is the specific contribution of SELECT, and it is worth being precise that the enrolled population had established cardiovascular disease. That is not the same as the general population and the result should not be quoted as though it were.
STEP 1 and STEP 4 are two different questions. The first asks what happens when treatment is added; the second asks what happens when it is withdrawn after a run-in. Quoting the first as evidence about maintenance is the commonest misreading of the programme.
I am describing what is, rather than arguing for what should be.
The 165 to 184 hour range: that is roughly 7 to 7.6 days, which is why the weekly schedule works. Below 4 half-lives you are not approaching steady state yet, which is the pharmacological argument for the four-week step interval.
One case, stated as one case.
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Coming back to: Semaglutide half-life: where the 165 to 184 hour figure comes from
Semaglutide half-life: where the 165 to 184 hour figure comes from Writing it up because I had to work it out twice and would rather nobody else did. Putting the numbers in the first post, because a question…
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+112 | 119 | 3.3k | 11mo |
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Molecular mass of semaglutide and why the figure differs between sources — does this still hold?
Molecular mass of semaglutide and why the figure differs between sources — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Putting the numbers in…
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+94 | 102 | 14k | 19mo |
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Revisiting: Semaglutide formulation: what is in the licensed product besides the peptide
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+72 | 77 | 7.2k | 19mo |
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Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile
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+115 | 122 | 2.6k | 1d |
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Semaglutide half-life: where the 165 to 184 hour figure comes from
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+128 | 145 | 3k | 4mo |
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Amylin analogue mechanism: satiety signalling separate from GLP-1
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+128 | 142 | 38k | 13mo |
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Chronic kidney disease and the FLOW result — a second dataset
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2 | 2.3k | 20mo | |
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Why semaglutide solutions can look faintly opalescent and when that matters
The question in the title: Why semaglutide solutions can look faintly opalescent and when that matters I will give what I have already checked below so nobody repeats it. A follow-up question about…
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+73 | 79 | 2k | 4mo |
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Molecular mass of semaglutide and why the figure differs between sources — does this still hold?
Molecular mass of semaglutide and why the figure differs between sources — does this still hold? — that is the question, and I have not found it answered plainly anywhere I have looked. Putting the numbers in…
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+94 | 102 | 14k | 19mo |
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[2026 update] Tirzepatide in obstructive sleep apnoea: reading SURMOUNT-OSA
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2 | 58k | 11mo |