Taking post #28 at face value and following it one step further.
Genuine question rather than a rhetorical one: has anyone here actually observed micro-titration, as opposed to read about it? The thread is long and I cannot tell.
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Practice · Dosing & titration · continued
Micro-titration: a disputed topic, argued properly posts 31–60
This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1 · go to the accepted answer.
Post #30 and I disagree about the size of the effect, not about the direction.
Adding a reference point for micro-titration. Mine is a single case, collected without controls, and I am posting the method alongside it so it can be discounted appropriately.
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g.amankwah, post #31: Taking post #28 at face value and following it one step further. Genuine question rather than a rhetorical one: has anyone here actually observed micro-titration, as opposed to read about it? The thread is long and I cannot tell. Go to post
Adding a data point of agreement rather than a data point.
Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.
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Collapsed as off-topic by two members at trust level 3 or above
Micro-titration: the concept of increments smaller than the labelled steps. It has no evidence base from trials but is described by some people. The downside is that very small increments are hard to measure accurately with a syringe.
A methods point on micro-titration rather than a substantive one: if the comparison is not like for like, the difference you are measuring is the difference in method.
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Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.
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Same experience here, different supplier, so it is at least not unique to one of them.
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I had written a reply contradicting post #39 and deleted it. Here is what survived.
Marking my uncertainty on micro-titration explicitly. I am confident about the direction, much less confident about the size, and not confident at all that it generalises past the case in the first post.
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Good question, well framed, and I would like to see it answered properly.
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steady_state, post #38: A methods point on micro-titration rather than a substantive one: if the comparison is not like for like, the difference you are measuring is the difference in method. Go to post
Picking up post #42: that is the part I would want checked first.
The maximum studied dose is a fact about the trial and not a ceiling on the molecule. It is also the last point at which anything is known, which is the reason to treat it as one.
g.haaland, post #20: Answering the question post #16 raises rather than the one it answers. Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose. Go to post
Coming back to post #44, because the follow-up matters more than the original answer.
The version of micro-titration that circulates here is a simplification of a simplification. It is not wrong, but it has lost the conditions under which it holds, and those conditions are where the interesting cases live.
Post #44 is right about the mechanism and I think understates the practical bit.
Micro-titration: the concept of increments smaller than the labelled steps. It has no evidence base from trials but is described by some people. The downside is that very small increments are hard to measure accurately with a syringe.
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Collapsed as off-topic by two members at trust level 3 or above
Going back down a step is not a failure and the trials allowed it. Several protocols permitted a return to the previous dose for tolerability and then a second attempt at the step.
Scoping that to what I have actually seen rather than what I have read.
outline_first, post #34: Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose. Go to post
I have three months of notes on micro-titration and the honest summary is that the trend is real and the week-to-week numbers are noise. I nearly drew the opposite conclusion from the first fortnight.
On post #48 — agreed on the reasoning, with one qualification.
Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.
That is the practical version. The rigorous version is longer and says the same thing.
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Holding a dose indefinitely: the trials did not study indefinite holding at a non-maximum dose. The trials escalated to a target and then held that. What happens if you stay at an intermediate dose for years is not formally studied and extrapolation is the best available reasoning.
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g.amankwah, post #31: Taking post #28 at face value and following it one step further. Genuine question rather than a rhetorical one: has anyone here actually observed micro-titration, as opposed to read about it? The thread is long and I cannot tell. Go to post
If you are new and reading this thread for the answer to micro-titration: the answer is conditional, the conditions are in the third reply, and the rest of the thread is worth skipping.
Post #54 is the version of this I will quote in future. One addition.
Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.
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k.asante, post #51: I have three months of notes on micro-titration and the honest summary is that the trend is real and the week-to-week numbers are noise. I nearly drew the opposite conclusion from the first fortnight. Go to post
Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.
Micro-titration: I would want to see the raw numbers rather than the summary before agreeing. Summaries lose exactly the information that would settle this.
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