This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.
Post #120 answers the question as asked. The question underneath it is different.
Acetate content: counter-ion content. Trifluoroacetate or acetate from the salt form of the peptide. Affects mass calculations and should be stated on a complete certificate.
The rule of thumb is fine; the edge cases are where it earns its keep.
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Particulates in a reconstituted solution: identifying the likely source
Posting this under the heading it deserves: Particulates in a reconstituted solution: identifying the likely source Everything below is what sits behind that. Something about particulates does not reconcile…
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+15 | 19 | 13k | 9mo |
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Particulates in a reconstituted solution: identifying the likely source — what changed since
Particulates in a reconstituted solution: identifying the likely source — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of…
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2 | 129 | 14mo | |
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Named, unnamed and unspecified impurities as regulatory categories
On the subject in the title: Named, unnamed and unspecified impurities as regulatory categories Working notes rather than a conclusion. Two reports on the same lot, and I would like help deciding whether they…
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+10 | 14 | 504 | 3mo |
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Endotoxin and why it is a separate question from purity
Endotoxin and why it is a separate question from purity Writing it up because I had to work it out twice and would rather nobody else did. A question about endotoxin that I think has a definite answer, unlike…
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2 | 22k | 4mo | |
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Deletion sequences: expected mass shifts by residue
Deletion sequences: expected mass shifts by residue — setting out what I have, and where I think it stops being reliable. Deletion sequences keeps being re-asked here and I think that is because the answer is…
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2 | 59 | 3mo |
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Interpreting a composition change that is within the error bars
On the subject in the title: Interpreting a composition change that is within the error bars Working notes rather than a conclusion. Asking about interpreting a composition change directly, because I have…
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+18 | 22 | 5.8k | 12mo |
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Preservatives: function, testing, and limits
Preservatives: function, testing, and limits — setting out what I have, and where I think it stops being reliable. An honest uncertainty about preservatives rather than a disguised assertion. I do not know…
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+23 | 27 | 3.7k | 16mo |
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[2026 update] Area percent versus weight percent: the confusion that causes most arguments
On the subject in the title: Area percent versus weight percent: the confusion that causes most arguments Working notes rather than a conclusion. Proposing that Area percent versus weight percent deserves a…
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+65 | 70 | 1.1k | 16d |
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Blinding yourself: practical methods and their limits
On the subject in the title: Blinding yourself: practical methods and their limits Working notes rather than a conclusion. A methods question rather than a substantive one, about blinding yourself. Everyone…
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+40 | 44 | 33k | 5d |
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Coming back to: Adsorption to container surfaces and to plastics
Adsorption to container surfaces and to plastics — setting out what I have, and where I think it stops being reliable. Adsorption — I have the observation and I do not trust my interpretation of it, so I am…
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2 | 459 | 17mo |