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Safety · Adverse events · continued

Persistent vomiting and the threshold for seeking help — one year on posts 31–44

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

AZ
an.zamoraTL221 Dec 2024#31
n.lehtinen, post #20: I have three months of notes on Persistent vomiting and the honest summary is that the trend is real and the week-to-week numbers are noise. I nearly drew the opposite conclusion from the first fortnight. Go to post

Adding a small correction to the Persistent vomiting summary above rather than a disagreement with it. The substance holds; one of the figures is out by a factor that matters.

1 like in reply to #20 19mo
S
SHermansenTL2Member21 Dec 2024#32

I had written a reply contradicting post #30 and deleted it. Here is what survived.

What I want from this Persistent vomiting thread is the list of things that would need to be true for the claim to hold. If we can write that list, we can check it.

7 likes 19mo
EB
e.bakkenTL222 Dec 2024#33

Picking up post #32: that is the part I would want checked first.

Injection-site reactions that spread over a day or come with systemic symptoms are a different observation from ordinary local reactions.

I have left out the parts I could not verify.

18 likes 19mo
R
RodriguesTL3Regular22 Dec 2024#34

The most useful contribution to this subcategory is a completed account: what happened, what was done, and what the outcome was.

0 likes 19mo
TV
t.vargaTL222 Dec 2024#35
l.dziedzic, post #19: Reporting here and reporting to a national scheme are not alternatives. The second is what feeds safety surveillance. If anyone has run this properly I would rather read that than my own guess. Go to post

Persistent vomiting: I have looked for the primary source twice and failed twice. Either it does not exist or it is somewhere I do not know to look, and I would like to know which.

4 likes in reply to #19 19mo
GR
gradient_reviewTL222 Dec 2024#36
KO
k.ogunleyeTL222 Dec 2024#37

Fair, and the limits you put on it are the part I will remember.

25 likes 19mo
MD
methods_draftTL2Member22 Dec 2024#38

Worth separating two things that post #34 runs together.

Medullary thyroid carcinoma is the reason these compounds are contraindicated in people with personal or family history of MTC or multiple endocrine neoplasia type 2. Rodent toxicology showed a signal; human evidence of causation is absent but caution is appropriate.

Somebody will have a better source than mine, and I hope they post it.

0 likes 19mo
IB
i.balogunTL222 Dec 2024#39

Post #38 answers the question as asked. The question underneath it is different.

Attribution is genuinely hard for a single case and the reporting schemes are designed to work with that. You are not expected to prove causation to file.

7 likes 19mo
JR
j.rasmussenTL2Regular22 Dec 2024 · edited#40
e.krastev, post #16: Severe, persistent abdominal pain, particularly radiating to the back, is not an ordinary gastrointestinal symptom and belongs with a clinician rather than a thread. Go to post

I would keep Persistent vomiting and the decision it usually gets used for separate in this thread. They are related and they are not the same question, and merging them is why the last one went badly.

17 likes in reply to #16 19mo
VR
v.rautioTL222 Dec 2024#41

That matches what I have seen, for whatever a single anecdote is worth.

20 likes 19mo
BJ
b.jankowiakTL3Regular23 Dec 2024#42

The most useful reply I ever got about Persistent vomiting was a request to state my units. It sounds like pedantry and it has saved me twice.

8 likes 19mo
RM
r.mensahTL223 Dec 2024#43

Post #39 describes the usual case. This is about the unusual one.

Nothing here is medical advice, and in this subcategory the phrase is doing more work than in any other on the site.

0 likes 19mo
YM
y.mensahTL3Wiki editor23 Dec 2024#44
i.balogun, post #39: Post #38 answers the question as asked. The question underneath it is different. Attribution is genuinely hard for a single case and the reporting schemes are designed to work with that. You are not expected to prove causation to file. Go to post

Adding the measurement that post #43 says would settle it.

What I can speak to on Persistent vomiting is narrow, so I will keep it narrow rather than generalising from it. Beyond that boundary I do not know.

0 likes in reply to #39 19mo

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