SHermansen
TL2 Member · Gdynia, PL
Keeps a personal log and shares the numbers when they are relevant, with the measurement caveats attached.
Joined 9 August 2025 · last posted 5d
85Posts here
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Reading a rodent study on a secretagogue without over-extrapolating — the long version Replied, post #58 · Compounds › Secretagogues & GH axis · 23 Jul 2026 · 0 likes Answering the question post #54 raises rather than the one it answers. What a well-designed human trial of a secretagogue would look like: randomised,…
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HbA1c lag and what it can and cannot tell you at eight weeks — one year on Replied, post #19 · Clinical › Bloodwork · 14 Jul 2026 · 6 likes Understood. Thank you for being specific about the limits of it.
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An 18-month record including the parts that went badly Replied, post #67 · Outcomes › Progress reports · 12 Jul 2026 · 8 likes Thank you — that answers what I came here to find out.
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What is genuinely unknown about long-term amylin agonism Replied, post #25 · Compounds › Cagrilintide & amylin analogues · 11 Jul 2026 · 1 like Amylin signalling is distinct from GLP-1 signalling. Amylin slows gastric emptying and promotes satiety through a different receptor and different neural pathways. The…
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Immortal time bias in a claims-database study — one year on Replied, post #8 · Evidence › Study critique · 5 Jul 2026 · 9 likes I had written a reply contradicting post #6 and deleted it. Here is what survived. Statistical significance and clinical importance are different and both are needed. A…
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Micro-titration: a disputed topic, argued properly Replied, post #87 · Practice › Dosing & titration · 10 Jun 2026 · 6 likes Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.…
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Micronutrient adequacy at low total intake Replied, post #14 · Nutrition & Training › Protein & intake · 6 Jun 2026 · 0 likes I have no financial interest in anything named in this thread and I want to say so before I comment on micronutrient adequacy, because it is the sort of subject where…
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An appeal that succeeded, with the letter structure — the long version Replied, post #41 · Access › Insurance & coverage · 2 Jun 2026 · 2 likes Appeal looks different depending on whether you are reading the primary literature or the summaries of it, and the difference is not in our favour.
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Reading a trial's population section before its results Replied, post #66 · Evidence › Trials · 29 May 2026 · 1 like Nothing in a trial report is medical advice about an individual, and the gap between a population estimate and a person is exactly where clinical judgement lives. Not…
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Revisiting: Primary endpoint hierarchies and why order matters Replied, post #21 · Evidence › Trials · 11 May 2026 · 29 likes Adding a small correction to the Primary endpoint hierarchies summary above rather than a disagreement with it. The substance holds; one of the figures is out by a…
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Reimbursement variation across member states Replied, post #5 · Regional › European Union · 2 May 2026 · 16 likes Coming back to the opening post, because the follow-up matters more than the original answer. Spain: AEMPS is the regulator. Public reimbursement for weight management…
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[2026 update] 0.3 mL versus 0.5 mL versus 1 mL barrels: resolution matters Replied, post #55 · Devices › Syringes & needles · 23 Apr 2026 · 0 likes That matches what I have seen, for whatever a single anecdote is worth.