Rotating between abdomen, thigh and upper arm: absorption differences — one year on

Rotating between abdomen, thigh and upper arm: absorption differences — one year on — setting out what I have, and where I think it stops being reliable.

Asking about Rotating between abdomen directly, because I have read four threads on it and each answered a slightly different question.

The version I want answered is the narrow one: given the method stated below, is the result within what anyone else has seen? I am not asking what it means yet.

Method, numbers and the two assumptions I am aware of making are below. If the assumptions are wrong that is more useful to me than agreement.

Leave real distance between consecutive sites rather than moving a centimetre. Repeatedly injecting one area changes the local tissue over time and eventually changes absorption there.

A partial answer, offered because a partial answer beats none.

Worth separating two things that the opening post runs together.

One more thing on Rotating between abdomen that took me far too long to see: the two figures people quote are not measuring the same quantity. Once you notice that, the apparent contradiction disappears.

This follows post #3 rather than contradicting it.

I would call the community position on Rotating between abdomen likely rather than established, and I would be comfortable defending that hedge.

Subcutaneous injection into abdominal tissue, thigh or upper arm is what the licensed labelling in this class describes, and the published comparisons found the differences in exposure between those sites small.

This is the sort of thing the wiki should carry and currently does not.

Confirming post #3 from a second method, which matters more than confirming it from a second person.

The failure mode on Rotating between abdomen is boring rather than dramatic. It is almost always the step everyone assumes was done correctly because it is too simple to get wrong.

On post #3 — agreed on the reasoning, with one qualification.

If you have to inject at a different time of day than usual, that is a much smaller perturbation than it feels for a weekly compound with a week-long half-life.

Genuine question rather than a rhetorical one: has anyone here actually observed Rotating between abdomen, as opposed to read about it? The thread is long and I cannot tell.

Everything in post #7 holds. The case it does not cover is the one I have.

I read the earlier replies on Rotating between abdomen twice before writing this, because I had assumed the opposite and wanted to be sure I was disagreeing with what was said rather than what I expected.

Subcutaneous injection into abdominal tissue, thigh or upper arm is what the licensed labelling in this class describes, and the published comparisons found the differences in exposure between those sites small.

Speaking only to Rotating between abdomen as I have actually seen it, rather than as it is usually described: the effect is real, it is smaller than the thread suggests, and the variance between people is larger than the effect.

A request rather than an answer: could whoever has the primary source for Rotating between abdomen post it? I have seen the claim three times this month and each version had lost a qualifier.

Post #12 is the version of this I will quote in future. One addition.

Drawing up with one needle and injecting with another: a reasonable practice if you have extra needles. Fresh needle for injection reduces tissue drag and can decrease discomfort. Not necessary, but not harmful either.

I have separated what I observed from what I concluded, which does not always happen.

Where I part company with post #10, and it is a narrow parting.

Needle length matters less than angle for subcutaneous delivery in most people. A short needle at ninety degrees and a longer one at forty-five put the material in roughly the same place.

I would treat the number as indicative rather than as a measurement.