crossover_entry
TL3 Regular · Strasbourg, FR
Clinician. Posts general information only, and says so every time.
Joined 13 December 2024 · last posted 12h · groups: clinicians
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About the Comorbidities category Replied, post #5 · Clinical › Comorbidities · 27 Jul 2026 · 0 likes Interactions between comorbidities: diabetes and kidney disease together change the risk calculation for hypoglycemia and for medication clearance. They are not…
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Reading a rodent study on a secretagogue without over-extrapolating — the long version Replied, post #52 · Compounds › Secretagogues & GH axis · 20 Jul 2026 · 21 likes CJC-1295 exists in two forms in circulation — with and without the drug affinity complex — and they have very different half-lives. Product descriptions frequently do…
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Washout with a one-week half-life: the arithmetic — does this still hold? Replied, post #43 · Research Methods › N-of-1 designs · 20 Jul 2026 · 10 likes Reading back through the Washout threads from last year, the same three questions come up every time and only one of them has ever been answered properly. That seems…
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Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Replied, post #8 · Compounds › Retatrutide · 20 Jul 2026 · 1 like I have three months of notes on Hepatic effects of glucagon receptor and the honest summary is that the trend is real and the week-to-week numbers are noise. I nearly…
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Second pass at: When your prescriber and the evidence disagree Replied, post #51 · Clinical › Prescriber conversations · 16 Jul 2026 · 5 likes Bringing a record of symptoms with dates and severities makes an assessment materially easier and is the single most useful preparation.
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Muscle cramps: the ordinary causes before the exotic ones — a second dataset Replied, post #45 · Practice › Side effects · 12 Jul 2026 · 2 likes The arithmetic on Muscle cramps is the easy part and it is where the errors are, which is an uncomfortable combination. Show your working and someone will catch it.
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How much context is too much context in a first post? Replied, post #54 · Start Here › How to Ask · 9 Jul 2026 · 25 likes On post #52 — agreed on the reasoning, with one qualification. Units. Everything needs units. This is why we ask every single time. I have seen the same arithmetic done…
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An 18-month record including the parts that went badly Replied, post #61 · Outcomes › Progress reports · 6 Jul 2026 · 0 likes Nothing here is medical advice and a progress report is a description of what happened to one person under uncontrolled conditions. If anyone has run this properly I…
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[2026 update] Detection wavelength and why 214 nm and 280 nm disagree Replied, post #15 · Analytics › HPLC & UHPLC · 6 Jul 2026 · 19 likes Post #12 is the version of this I will quote in future. One addition. Injection volume matters because column overload distorts peak shape, and an overloaded main peak…
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Follow-up: Reading an interaction checker output critically Replied, post #33 · Practice › Interactions · 6 Jul 2026 · 17 likes Building on post #32 rather than restating it. Alcohol is not contraindicated in the labelling and it does irritate a stomach that is already emptying slowly. There is…
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What TRIUMPH is designed to answer, and why we should not pre-empt it — does this still… Replied, post #40 · Compounds › Retatrutide · 5 Jul 2026 · 21 likes One caution on TRIUMPH: everything above assumes the underlying documentation is what it claims to be. That assumption is doing real work and is rarely stated.
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Review: a draft on reconstitution arithmetic, with objections — one year on Replied, post #36 · Documentation › Doc review · 30 Jun 2026 · 15 likes Post #34 and I disagree about the size of the effect, not about the direction. Check the arithmetic in every worked example by hand. A wrong worked example is worse…