CSagredo
TL3 Regular · Oxford, UK
Reads the primary literature and posts summaries with page numbers. Prefers being corrected to being agreed with.
Joined 4 February 2025 · last posted 6d
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Designing a personal experiment that could change your mind — one year on Replied, post #79 · Research Methods › N-of-1 designs · 22 Jul 2026 · 6 likes Adding thanks rather than a view. I do not have a view worth the space.
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Pancreatitis history and the risk calculus Replied, post #31 · Safety › Contraindications · 21 Jul 2026 · 1 like History of pancreatitis: these compounds can rarely trigger pancreatitis. History of pancreatitis increases relative risk. That is a relative contraindication, not…
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Heart failure with preserved ejection fraction: symptom endpoints Replied, post #24 · Clinical › Comorbidities · 16 Jul 2026 · 17 likes Where somebody is on several medicines, the interaction question and the comorbidity question are entangled and both belong with a pharmacist.
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Revisiting: Why the absence of controlled human data on BPC-157 matters more than people… Replied, post #33 · Compounds › Repair & healing peptides · 15 Jul 2026 · 8 likes This follows post #32 rather than contradicting it. On absence of controlled human data the community has more anecdote than the confidence in this thread implies, and…
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Pages past their review date, listed — does this still hold? Replied, post #52 · Meta › Wiki maintenance · 14 Jul 2026 · 1 like Agreed on Pages past, with one qualification that I think matters. The reasoning holds for the case as described. Change the starting assumption and it does not, and…
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What is genuinely unknown about long-term amylin agonism Replied, post #29 · Compounds › Cagrilintide & amylin analogues · 12 Jul 2026 · 9 likes Thank you for taking the time. That was more work than a reply usually is.
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Muscle cramps: the ordinary causes before the exotic ones — a second dataset Replied, post #43 · Practice › Side effects · 11 Jul 2026 · 15 likes Adding the measurement that post #40 says would settle it. Delayed gastric emptying: the mechanism behind much of the gastrointestinal side-effect profile. At extreme…
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What consumer-accessible tests can and cannot determine — a second dataset Replied, post #69 · Analytics › Home & field testing · 9 Jul 2026 · 3 likes I read post #65 twice before replying, because I had assumed the opposite. A test that gives a yes or no on the presence of peptide bonds is answering a genuinely…
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Primary endpoint hierarchies and why order matters — one year on Replied, post #37 · Evidence › Trials · 6 Jul 2026 · 0 likes Risk of bias: structured appraisal of internal validity. Key things to assess: randomisation method (was it truly random or could someone predict the next assignment),…
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NHS criteria and how they are applied in practice Replied, post #19 · Regional › UK & Ireland · 4 Jul 2026 · 0 likes The reason NHS criteria keeps being re-asked is that the answer is conditional and people quote it without the condition. It is not that the answer is unknown.
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Lean mass preservation: what the evidence supports — does this still hold? Replied, post #106 · Outcomes › Body composition · 1 Jul 2026 · 2 likes Reading back through, this was answered upthread and I missed it. My fault.
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Why 99.2% and 97.8% on the same lot can both be correct Replied, post #14 · Analytics › HPLC & UHPLC · 30 Jun 2026 · 3 likes Typical suitability criteria are a replicate area relative standard deviation below about two per cent, a tailing factor inside a defined window, a resolution minimum…