This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.
Needle length for subcutaneous delivery is a question about tissue depth and injection angle together. Short needles at ninety degrees and longer ones at an angle reach comparable depths.
Stating my assumptions rather than smuggling them in.
What would change my mind on Gauge and length selection is a second dataset collected by someone with no stake in the first. Until then I hold it loosely and I would rather say so than pretend to more.
Post #31 is the version of this I will quote in future. One addition.
Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum.
The right answer here may simply be that it has not been measured.
Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less.
One more caveat and then I will stop qualifying: the sample selected itself.
Post #36 is the version of this I will quote in future. One addition.
Gauge and length selection has been discussed here with more heat than it deserves, mostly because two definitions have been in play the whole time.
Worth separating two things that post #36 runs together.
U-100 means the barrel is graduated for a solution containing one hundred units of insulin per millilitre. For anything that is not insulin, the units are simply hundredths of a millilitre.
Someone will know this better than I do and I hope they say so.
Narrowing post #40, because the general version has more than one answer.
Two things can be true about Gauge and length selection at once: the mechanism is plausible and the evidence for the size of the effect is thin. Most of the argument here is people defending the first against attacks on the second.
Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm (standard), or 10-12 mm (longer). Longer needles are needed for deeper tissue or if you have abdominal adiposity.
Post #42 and I disagree about the size of the effect, not about the direction.
U-100 means the barrel is graduated for a solution containing one hundred units of insulin per millilitre. For anything that is not insulin, the units are simply hundredths of a millilitre.
Post #44 answers the question as asked. The question underneath it is different.
Aspirating before injection: for subcutaneous injection, aspirating (pulling back on the plunger to check for blood) is not necessary and is sometimes discouraged because it is associated with more discomfort. Subcutaneous injection without aspiration is standard practice.
I would want to see it done twice before believing it once.
Reading back through, this was answered upthread and I missed it. My fault.
Source for the Gauge and length selection figure, since it was asked for. It is in the discussion rather than the abstract, which is why the version circulating is stronger than the paper is.
Reading the surrounding paragraph is worth the two minutes. The authors are more careful than their summarisers.
I disagree with the framing of Gauge and length selection above, and I think it is a substantive disagreement rather than a terminological one. Setting out why, so it can be checked.
The reasoning depends on an assumption that is doing a lot of work and is never stated. If the assumption holds, the conclusion follows. I do not think it holds generally.
Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum.
That is the version I would defend. It is not the version I started with.
U-100 means the barrel is graduated for a solution containing one hundred units of insulin per millilitre. For anything that is not insulin, the units are simply hundredths of a millilitre.
I have separated what I observed from what I concluded, which does not always happen.
Gauge and length selection: I would want to see the raw numbers rather than the summary before agreeing. Summaries lose exactly the information that would settle this.
Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum.
Small point, but it is the one that usually catches people.
Gauge is the outside diameter and higher numbers are thinner. Thinner needles hurt less and draw more slowly, which is the entire trade.
It is one reading of the data and not the only reasonable one.
Reusing a needle blunts it and there is no benefit to offset that. The second injection with the same needle is the one people describe as painful.
Answering the question post #54 raises rather than the one it answers.
What I would check first on Gauge and length selection is whether the thing being measured moved or whether the way of measuring it moved. Those look identical in a graph.
A definition problem is doing most of the work in this Gauge and length selection discussion. Once the term is pinned down I suspect the disagreement mostly goes away and what is left is small.
U-100 means the barrel is graduated for a solution containing one hundred units of insulin per millilitre. For anything that is not insulin, the units are simply hundredths of a millilitre.
If it helps: the failure mode here is usually boring rather than dramatic.
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