Second pass at: Metformin co-administration and additive GI effects

On post #4 — agreed on the reasoning, with one qualification.

Where a published interaction study exists it usually reports an area-under-curve ratio, and that number is far more informative than a yes-or-no answer.

Correct me on the arithmetic if it is wrong; I would rather know.

A supplement is a drug for interaction purposes, and the fact that it is sold without a prescription tells you nothing about whether it interacts. The paperwork is usually worse rather than better.

Nothing above should be read as advice about what anyone else should do.

Posting my Metformin co-administration numbers with the method attached so they can be discounted properly. Uncontrolled, unblinded, and collected by someone who wanted a particular answer.

I read post #37 twice before replying, because I had assumed the opposite.

Where I would push back on the Metformin co-administration consensus is the confidence, not the direction. The direction looks right. The confidence is borrowed.

Reading back through, this was answered upthread and I missed it. My fault.

Building on post #90 rather than restating it.

Counterpoint on Metformin co-administration, offered without confidence: the same observation is consistent with a much duller explanation, and nobody has ruled the dull one out.

Reading back through the Metformin co-administration threads from last year, the same three questions come up every time and only one of them has ever been answered properly. That seems like a documentation gap rather than a knowledge gap.

Metformin co-administration has been discussed here with more heat than it deserves, mostly because two definitions have been in play the whole time.

Where the Metformin co-administration discussion usually stalls is that nobody wants to say "I do not know" and everyone is willing to say "it varies". Those are the same sentence with different clothes on.