Second pass at: Pregnancy and pregnancy planning: contraindication and washout posts 121–128

Nothing in this subcategory is medical advice and the questions asked here are precisely the ones that need an individual assessment.

Marking my uncertainty on Pregnancy and pregnancy planning explicitly. I am confident about the direction, much less confident about the size, and not confident at all that it generalises past the case in the first post.

That is the distinction I keep failing to hold on to. Written down now.

Coming back to post #120, because the follow-up matters more than the original answer.

If someone has run Pregnancy and pregnancy planning properly I would rather read that than my own reconstruction of it. Posting mine only because the thread has gone quiet.

Genetic and ancestry-related differences in response are asked about regularly and the published evidence is thin enough that the honest answer is short.

Reading it again, the caveat matters more than the finding.

My experience of Pregnancy and pregnancy planning contradicts the reply above. I am posting it as a data point rather than as a refutation, because one person's experience is exactly that.

Post #126 answers the question as asked. The question underneath it is different.

On Pregnancy and pregnancy planning: the maintained page in the documentation commons covers the general case with citations and a review date, which is more reliable than any reply here including this one.

Extrapolating a point estimate to somebody well outside the enrolled range should be described as an extrapolation every time it is done.