Semaglutide half-life: where the 165 to 184 hour figure comes from

Is there a ceiling dose beyond which the effect plateaus? The trials did not study that because they stopped at 2.4 mg. Some people report trying higher doses, but trial data is absent and off-label dosing enters territory this site does not advise on.

I have left out the parts I could not verify.

I would rather this thread reach "we do not know" about semaglutide half-life than reach a confident answer that nobody can support when asked.

Discontinuation rates in the trials are worth reading alongside efficacy and almost never are. A large mean effect in a population where a meaningful fraction stopped early is telling you two things, not one.

Adding it because I spent an afternoon working it out and nobody should have to twice.

Acknowledging rather than arguing. The reasoning holds as far as I can follow it.

Where I part company with post #77, and it is a narrow parting.

The 165 to 184 hour half-life range gets quoted as a fixed number. It is a range across a studied population, and individual clearance varies enough that a person's own steady state may be reached earlier or later than the population average implies.

Coming back to post #101, because the follow-up matters more than the original answer.

On the injection-day question: the labelling for licensed semaglutide allows the day to be changed provided at least two days separate the two injections. That interval is not arbitrary — it is what stops two doses stacking inside one absorption window.

The general answer and the answer for your case may diverge here.

This follows post #115 rather than contradicting it.

I think the semaglutide half-life question is answerable and has not been answered, which is a more optimistic position than most of this thread.

The 165 to 184 hour half-life range gets quoted as a fixed number. It is a range across a studied population, and individual clearance varies enough that a person's own steady state may be reached earlier or later than the population average implies.

The reason semaglutide half-life is hard to answer is that the obvious measurement and the relevant quantity are not the same thing, and substituting one for the other is silent.