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Devices · Pens & autoinjectors

Storing a pen in use versus a pen unopened

AR
a.reyesTL4 Admin26 Feb 2025#1

Storing a pen in use versus a pen unopened Writing it up because I had to work it out twice and would rather nobody else did.

Proposing that storing a pen deserves a maintained page rather than a recurring topic, and drafting the skeleton here so that the argument about scope happens before the writing rather than after.

What I think belongs on it, what does not, and the three claims that would need a citation each.

0 likes 17mo
DS
dr_seongTL3Physician8 Mar 2025 · edited#2

Holding the pen in place for the stated count after the plunger stops is the manufacturer's answer to leakage at the site. It is on the instruction leaflet and it is the step most often skipped.

That is what I would do. It may not be what is correct.

24 likes 17mo
YA
y.asanteTL216 Mar 2025#3

The opening post put the caveat in the right place and I want to underline it.

Comparing cost per milligram between a pen and a vial ignores wastage, dead volume and the number of doses actually obtainable. Cost per delivered dose at your dose is the comparison that survives.

7 likes 16mo
JW
journalclub_wrenTL3Regular23 Mar 2025#4

A pen that has been dropped may not be visibly damaged and may not deliver accurately afterwards. Manufacturers say to replace rather than to test, and there is no test a user can do.

1 like 16mo
TK
t.karlsenTL229 Mar 2025#5
y.asante, post #3: The opening post put the caveat in the right place and I want to underline it. Comparing cost per milligram between a pen and a vial ignores wastage, dead volume and the number of doses actually obtainable. Cost per delivered dose at your dose is the comparison that survives. Go to post

Storage after first use: most pens can be stored at room temperature after first use, even if unrefrigerated, for a limited time (often 28 days). Check your specific pen's labelling.

0 likes in reply to #3 16mo
WN
w.novakTL3Regular4 Apr 2025#6

Needle installation: some pens require a fresh needle for each injection; others have a single needle that stays attached. Check the design of your pen.

That has been true for the cases I have seen and I have not seen many.

17 likes 16mo
HE
h.espinozaTL210 Apr 2025#7

Post #5 and I disagree about the size of the effect, not about the direction.

Pen confusion between compounds: if you are using multiple pens or alternating pens, confirming you have the correct pen before injection prevents administration errors. Check the label every time.

I looked this up rather than remembered it, which is the right order.

4 likes 16mo
ST
slow_titratorTL2Regular16 Apr 2025#8

Adding a note of thanks rather than an opinion. I did not know most of that.

0 likes 15mo
CG
c.grimaldiTL221 Apr 2025#9
journalclub_wren, post #4: A pen that has been dropped may not be visibly damaged and may not deliver accurately afterwards. Manufacturers say to replace rather than to test, and there is no test a user can do. Go to post

I read post #5 twice before replying, because I had assumed the opposite.

A pen that will not dial to the intended dose is usually telling you the cartridge does not contain enough for it. That is a designed behaviour rather than a fault.

25 likes in reply to #4 15mo
FV
f.villalobosTL227 Apr 2025#10

Post #9 answers the question as asked. The question underneath it is different.

Nothing here is medical advice, and pen technique is the single easiest thing to have demonstrated in person rather than learned from a description.

12 likes 15mo
RI
r.ilungaTL22 May 2025#11

Priming: most pens require priming before the first use (injecting a small amount to fill the needle and line). Not priming can result in no dose being delivered on the first injection.

1 like 15mo
ED
e.dalgleishTL37 May 2025#12
MB
ma.balogunTL212 May 2025#13
c.grimaldi, post #9: I read post #5 twice before replying, because I had assumed the opposite. A pen that will not dial to the intended dose is usually telling you the cartridge does not contain enough for it. That is a designed behaviour rather than a fault. Go to post

Sensible. I would want the same detail before I acted on it either.

23 likes in reply to #9 15mo
D
DOdendaalTL3Regular16 May 2025#14
ma.balogun, post #13: Sensible. I would want the same detail before I acted on it either. Go to post

Off-label dosing with a pen: if you want to deliver a dose different from the pen's pre-set steps (e.g., halfway between two step doses), that is off-label use. Some pens allow it; others do not. Confirm before attempting.

0 likes in reply to #13 14mo
NZ
n.zielinskiTL221 May 2025#15

A pen delivers a fixed or dialled dose from a cartridge and is a metering device rather than simply a covered syringe. That is why dose changes are constrained to whatever the mechanism supports.

That is the version I use. It may not be the version that is correct.

0 likes 14mo
M
MJayawardenaTL3Regular26 May 2025#16

Post #14 and I disagree about the size of the effect, not about the direction.

Storage instructions for a pen typically differ before and after first use, and the in-use period is the one people miss. It is on the carton.

I am not the right person to answer the follow-up to this.

3 likes 14mo
DN
d.nilsenTL230 May 2025 · edited#17

A pen taken straight from the refrigerator is uncomfortable to inject for the same reason a cold syringe is. Room temperature for a short while first is the standard advice.

16 likes 14mo
O
OTeixeiraTL3Regular4 Jun 2025#18
dr_seong, post #2: Holding the pen in place for the stated count after the plunger stops is the manufacturer's answer to leakage at the site. It is on the instruction leaflet and it is the step most often skipped. That is what I would do. It may not be what is correct. Go to post

Disposal of a used pen is a sharps question even where the needle is retracted, and local rules vary more than people expect.

That holds for the case as described. Change the assumptions and it may not.

32 likes in reply to #2 14mo
RM
r.mensahTL29 Jun 2025#19

Adding the measurement that post #18 says would settle it.

Travel with a pen raises a cold-chain question and a documentation question. The second is the one people forget until an airport.

The reasoning is more useful than the number, which is why I have shown it.

0 likes 14mo

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