Ranked by engagement

Top topics — this quarter page 2

Ranked by replies, likes and views over this quarter, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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515 topics · page 2 of 14

Topic	Participants	Replies	Views	Activity
Coming back to: Why a preprint's supplementary material is often the best part Evidence › Preprints risk of bias effect size preprint Under review Why a preprint's supplementary material is often the best part — that is the question, and I have not found it answered plainly anywhere I have looked. A question about how this site should cite something…	+109	116	36k	2d
Revisiting: The best-written scientific paper you have read Lounge › Off topic beginner friendly long read Posting this under the heading it deserves: Revisiting: The best-written scientific paper you have read Everything below is what sits behind that. Asking about best-written scientific paper directly, because…	+102	121	21k	1h
Request: a per-category review queue Meta › Feature requests site feedback translation wiki post Request: a per-category review queue Writing it up because I had to work it out twice and would rather nobody else did. Per-category review queue — I have the observation and I do not trust my interpretation…	+121	136	13k	2h
Personal import allowances, compared — a second dataset Access › International personal import telehealth MHRA EMA Wiki Personal import allowances, compared — a second dataset — setting out what I have, and where I think it stops being reliable. Posting a small dataset on Personal import allowances. It is mine, it is…	+124	132	9.2k	2mo
Journal club: is percentage weight change the right endpoint? Evidence › Journal club number needed to treat randomised trial journal club Solved Journal club: is percentage weight change the right endpoint? I have a specific reason for asking rather than idle curiosity, and the context is below. Bringing a claim rather than a paper, because the claim…	+116	120	23k	3mo
Reference intervals: how they are constructed and why one in twenty flags Clinical › Bloodwork HbA1c thyroid function eGFR & renal function lipase & amylase Under review Reference intervals: how they are constructed and why one in twenty flags — setting out what I have, and where I think it stops being reliable. Reference intervals: what I expected, what I found, and the gap…	+104	119	30k	1mo
What is genuinely unknown about long-term amylin agonism Compounds › Cagrilintide & amylin analogues randomised trial cagrilintide cagrisema amylin analogues Solved What is genuinely unknown about long-term amylin agonism — that is the question, and I have not found it answered plainly anywhere I have looked. A comparison question rather than a question about one…	+83	91	46k	1d
Spreadsheets: an appreciation — what changed since Lounge › Off topic long read beginner friendly Spreadsheets: an appreciation — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Spreadsheets is wrong? I ask because I have…	+102	113	26k	17h
Reading a trial's population section before its results Evidence › Trials estimand surrogate endpoints discontinuation & dropout randomised trial Solved On the subject in the title: Reading a trial's population section before its results Working notes rather than a conclusion. Reading STEP 2 ( Lancet , 2021) for the population rather than the effect, which I…	+91	109	22k	2mo
Submitting a sample: the process end to end Sourcing › Independent verification blind sampling PeptideMeter VendorInvestigate third-party testing On the subject in the title: Submitting a sample: the process end to end Working notes rather than a conclusion. Submitting a sample keeps being re-asked here and I think that is because the answer is…	+99	114	29k	21h
The "under review" status pill and when a moderator applies it Evidence › Preprints risk of bias effect size preprint Posting this under the heading it deserves: The "under review" status pill and when a moderator applies it Everything below is what sits behind that. A question about how this site should cite something that…	+96	119	17k	3mo
Stepping down deliberately, and how to do it without losing progress Practice › Dosing & titration worked example semaglutide tirzepatide dose reduction Stepping down deliberately, and how to do it without losing progress — setting out what I have, and where I think it stops being reliable. Practical question with the units stated, because I have seen how…	+98	102	26k	3mo
I joined for one answer and stayed for a year — what changed my mind Start Here › Welcome guidelines onboarding trust levels Posting this under the heading it deserves: I joined for one answer and stayed for a year — what changed my mind Everything below is what sits behind that. Question in the title and the context underneath, in…	+95	114	17k	just now
Official shortage notices and what they authorise Access › Shortages compounding formulary shortage Posting this under the heading it deserves: Official shortage notices and what they authorise Everything below is what sits behind that. Trying to work out what would count as evidence on official shortage…	+106	119	18k	1mo
Trust level 3 requirements: a clarification — does this still hold? Meta › Announcements trust levels moderation site feedback guidelines Solved Asking directly, because I could not find a straight answer: Trust level 3 requirements: a clarification — does this still hold? Two things I would like separated before anyone answers on Trust level 3…	+77	90	57k	9h
Follow-up: Tirzepatide and nausea: is the profile genuinely different or just differently reported? Compounds › Tirzepatide tirzepatide SURMOUNT programme effect size randomised trial Solved Tirzepatide and nausea: is the profile genuinely different or just differently reported? I have a specific reason for asking rather than idle curiosity, and the context is below. Something about Tirzepatide…	+109	122	3.6k	2mo
Coming back to: Time to steady state after a dose increase Pharmacology › Pharmacokinetics semaglutide missed dose liraglutide worked example Time to steady state after a dose increase Writing it up because I had to work it out twice and would rather nobody else did. Working through the kinetics rather than the pharmacology, because I think the…	+104	110	16k	2d
Pooling trials with different estimands Evidence › Meta-analyses publication bias risk of bias effect size meta-analysis Solved On the subject in the title: Pooling trials with different estimands Working notes rather than a conclusion. Asking about pooling trials with different estimands on behalf of the question I keep seeing asked…	+120	132	2.3k	1d
Forced degradation studies: designing one that is informative Analytics › Method validation precision & repeatability recovery stability-indicating method Under review Posting this under the heading it deserves: Forced degradation studies: designing one that is informative Everything below is what sits behind that. Collecting what is known about forced degradation studies…	+100	106	35k	2d
Anaesthesia and elective surgery: the aspiration question Practice › Interactions metformin insulin delayed gastric emptying hypoglycaemia Posting this under the heading it deserves: Anaesthesia and elective surgery: the aspiration question Everything below is what sits behind that. A narrow question about anaesthesia and elective surgery,…	+103	115	6.6k	3mo
Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Compounds › Semaglutide STEP programme type 2 diabetes randomised trial SELECT trial Posting this under the heading it deserves: Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Everything below is what sits behind that. Semaglutide and gastric emptying,…	+115	122	2.6k	1d
Why the titration planner refuses to produce a schedule below a floor Data & Tools › Calculators syringe units site feedback concentration maths Solved Asking directly, because I could not find a straight answer: Why the titration planner refuses to produce a schedule below a floor Titration planner refuses — I have the observation and I do not trust my…	+76	83	53k	2mo
Common supplements people ask about, assessed one at a time Practice › Interactions insulin needs a source hypoglycaemia metformin Common supplements people ask about, assessed one at a time — setting out what I have, and where I think it stops being reliable. A follow-up question about common supplements that I did not know to ask the…	+101	107	28k	12h
A site rotation scheme that is easy enough to actually follow Practice › Administration needle gauge & length missed dose injection site rotation aseptic technique On the subject in the title: A site rotation scheme that is easy enough to actually follow Working notes rather than a conclusion. Two things I would like separated before anyone answers on site rotation…	+112	125	5.8k	21h
Lean mass preservation: what the evidence supports — does this still hold? Outcomes › Body composition bioimpedance lean mass loss data table DXA Asking directly, because I could not find a straight answer: Lean mass preservation: what the evidence supports — does this still hold? What changes if the standard account of Lean mass preservation is wrong?…	+112	122	5.2k	20h
Stepping down deliberately, and how to do it without losing progress — what changed since Practice › Dosing & titration tirzepatide semaglutide titration missed dose Under review Posting this under the heading it deserves: Stepping down deliberately, and how to do it without losing progress — what changed since Everything below is what sits behind that. Something changed and I would…	+94	99	29k	2d
A certificate whose chromatogram axes do not match its stated method — one year on Sourcing › Red flags mislabelling moderation documentation quality Solved A certificate whose chromatogram axes do not match its stated method — one year on Writing it up because I had to work it out twice and would rather nobody else did. Posting a small dataset on certificate…	+103	111	8.1k	2mo
The anatomy of a question that gets answered within an hour Start Here › How to Ask worked example site feedback onboarding beginner friendly Wiki The anatomy of a question that gets answered within an hour — setting out what I have, and where I think it stops being reliable. Question in the title. Context below, and I have tried to include the things…	+114	127	2.7k	13h
Named, unnamed and unspecified impurities as regulatory categories — the long version Analytics › Impurities & related substances HPLC data table forced degradation counter-ion content Wiki Named, unnamed and unspecified impurities as regulatory categories — the long version — setting out what I have, and where I think it stops being reliable. Two reports on the same lot, and I would like help…	+112	120	7.6k	5h
Coming back to: A community side-effect dataset, with its response rate and biases Data & Tools › Datasets observational data site feedback data table Solved Posting this under the heading it deserves: A community side-effect dataset, with its response rate and biases Everything below is what sits behind that. Community side-effect dataset — I have the observation…	+96	101	33k	2d