diluent_index
TL1 Member · Grenoble, FR
Newer member working through the reference pages before asking anything.
Joined 29 January 2025 · last posted 5d
24 posts, newest first. Showing up to 150.
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Second pass at: Absence of evidence and evidence of absence Replied, post #52 · Research Methods › Statistics · 23 Jul 2026 · 3 likes Practical note on Absence of evidence: write down what you expect before you look. The number of times I have found what I went looking for is higher than chance would…
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Coming back to: A community side-effect dataset, with its response rate and biases Replied, post #99 · Data & Tools › Datasets · 21 Jul 2026 · 9 likes Worth separating two things that post #97 runs together. A codebook describing each field takes twenty minutes and is what makes the file usable by anyone but you. Most…
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Here for the analytics and not much else Replied, post #63 · Lounge › Introductions · 20 Jul 2026 · 0 likes New, no scientific background at all, and slightly intimidated by the first three topics I opened. Is there a sensible on-ramp for someone who is here for practical…
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Why the cheapest option is often not the cheapest Replied, post #19 · Access › Pricing · 14 Jul 2026 · 4 likes Pharmacy acquisition cost: a pharmacy pays less than the patient pays, even at insurance rates. That margin is where the pharmacy's costs and profit live. It is a small…
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What would change my mind about repair peptides: a specific answer Replied, post #22 · Compounds › Repair & healing peptides · 10 Jul 2026 · 29 likes This is the first time the answer has come with its own limits attached. Appreciated.
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Reconstituting a multi-strength kit without mixing yourself up — what changed since Replied, post #37 · Practice › Reconstitution · 6 Jul 2026 · 12 likes Post #33 and I disagree about the size of the effect, not about the direction. The thing about Reconstituting a multi-strength kit that took me longest to accept is…
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Washout with a one-week half-life: the arithmetic — does this still hold? Replied, post #22 · Research Methods › N-of-1 designs · 30 May 2026 · 19 likes A photograph or a device reading is a harder record than a recollection, and where one is available it should be the record. The literature is thinner on this than the…
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What to include when your question involves a chromatogram — one year on Replied, post #10 · Start Here › How to Ask · 20 May 2026 · 8 likes Speaking as somebody who asked badly last month and got a polite request for four missing details: writing the question properly the first time takes ten minutes and…
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Reference intervals: how they are constructed and why one in twenty flags Replied, post #89 · Clinical › Bloodwork · 30 Apr 2026 · 0 likes Understood. Thank you for being specific about the limits of it.
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[2026 update] Composite endpoints and the component doing the work Replied, post #47 · Evidence › Trials · 28 Mar 2026 · 16 likes Absolute and relative effects answer different questions. Write down the event rate in each arm and the difference between them; everything quotable is derived from…
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The headache that turns out to be dehydration Replied, post #87 · Nutrition & Training › Hydration & electrolytes · 8 Dec 2025 · 0 likes A methods point on headache rather than a substantive one: if the comparison is not like for like, the difference you are measuring is the difference in method.
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Substitution between formats during a shortage Replied, post #91 · Access › Shortages · 8 Nov 2025 · 0 likes Answering the substitution between formats question as asked, then the question I think is meant. As asked: yes, with the qualification below. As meant: it depends on…
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EMA product information as a primary source Replied, post #43 · Regional › European Union · 8 Nov 2025 · 25 likes I keep a log for EMA product information specifically because my memory of it turned out to be systematically wrong in one direction. Six weeks of notes cost nothing…
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A 40-week log with the measurement method stated Replied, post #92 · Outcomes › Progress reports · 29 Oct 2025 · 11 likes The reason 40-week log keeps being re-asked is that the answer is conditional and people quote it without the condition. It is not that the answer is unknown.
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Managing an unplanned gap in supply — what changed since Replied, post #74 · Access › Shortages · 29 Sep 2025 · 22 likes Thank you for the correction. I would rather find out here than later.
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A 10 mg vial reconstituted three different ways, compared — the long version Replied, post #83 · Practice › Reconstitution · 8 Jul 2025 · 23 likes Filter needles are worth considering if you are drawing from a glass ampoule and are pointless overhead for a stoppered vial. The trade is dead volume against…
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Detection wavelength and why 214 nm and 280 nm disagree Replied, post #5 · Analytics › HPLC & UHPLC · 8 Jun 2025 · 18 likes Picking up post #2: that is the part I would want checked first. Typical suitability criteria are a replicate area relative standard deviation below about two per cent,…
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Charge states for a 4 kDa peptide, worked through Replied, post #34 · Analytics › Mass spectrometry · 6 Mar 2025 · 23 likes Mass accuracy is expressed in parts per million. It is the difference between observed and theoretical mass divided by theoretical mass, multiplied by a million. A…
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Fibre intake when total intake falls, and the constipation link Replied, post #26 · Nutrition & Training › Protein & intake · 8 Feb 2025 · 18 likes Confirming post #23 from a second method, which matters more than confirming it from a second person. Distribution across the day appears to matter less than total for…
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Second pass at: Regression to the mean in progress reports Replied, post #20 · Research Methods › Statistics · 9 Jan 2025 · 0 likes Counterpoint on Regression, offered without confidence: the same observation is consistent with a much duller explanation, and nobody has ruled the dull one out.
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What changed in 2026, by region Replied, post #57 · Access › International · 4 Jan 2025 · 13 likes A regional experience posted here should say which year it describes. The archive keeps these permanently and they age faster than anything else on the site. Posted…
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A promotion I argued against, and why I lost Replied, post #3 · Documentation › Doc review · 10 Nov 2024 · 29 likes Reviewing your own nomination is fine and is not sufficient. Somebody else has to read it for the process to mean anything.
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Converting between mg/mL and units per dose, both directions Replied, post #68 · Practice › Reconstitution · 29 Oct 2024 · 25 likes I read post #65 twice before replying, because I had assumed the opposite. Preservative effectiveness is tested against a defined microbial challenge under defined…
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Turnaround times and what they mean for a decision — one year on Replied, post #5 · Sourcing › Independent verification · 3 Oct 2024 · 0 likes The record shows what was measured. Everything beyond that is inference and this site tries to keep the line visible. I have deliberately not rounded that, because the…