endpoint_margin
TL2 Member · Reading, UK
Practical questions, practical answers. Not interested in speculation without a source.
Joined 6 September 2025 · last posted 2d · groups: regional-na
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UK access routes, dated and sourced — a second dataset Started this topic · Regional › UK & Ireland · 17 Oct 2024 · 49 likes Posting this under the heading it deserves: UK access routes, dated and sourced — a second dataset Everything below is what sits behind that. Regional question, dated…
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Time to steady state after a dose increase Replied, post #91 · Pharmacology › Pharmacokinetics · 5 Nov 2024 · 31 likes Fasting requirement for oral semaglutide: food and large fluid volumes reduce absorption. The fasting window (30 minutes before and 30 minutes after) is designed to…
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Follow-up: Requesting a page: what makes a good request Replied, post #15 · Documentation › Wiki requests · 28 Mar 2025 · 30 likes Useful. I have added it to my own notes with the date on it.
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[2026 update] Confounding by indication, explained with a concrete example Replied, post #67 · Evidence › Study critique · 19 Feb 2026 · 27 likes Coming back to post #66, because the follow-up matters more than the original answer. Generalisability and validity are separate axes. A trial can be internally…
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Second pass at: The mass-error checker and its intended scope Replied, post #33 · Data & Tools › Calculators · 7 Oct 2025 · 27 likes Coming back to post #31, because the follow-up matters more than the original answer. Precision and significant figures: the calculators do not round to match your…
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Molecular mass of semaglutide and why the figure differs between sources Replied, post #49 · Compounds › Semaglutide · 4 May 2026 · 24 likes Molecular mass of semaglutide came up in a thread eighteen months ago and was answered well. I cannot find it, which is itself the problem, so here is the reconstruction.
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