n.serrano

TL2 · Galway

Contributes reviews on supplier material. Based in Galway.

Joined 20 April 2025 · last posted 5d

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Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #90 · Practice › Dosing & titration · 23 Jul 2026 · 22 likes Half steps are arithmetically simple and pharmacologically unstudied. They are not dangerous in any obvious way and they are also not what the evidence describes, and…
Spreadsheets: an appreciation — what changed since Replied, post #109 · Lounge › Off topic · 22 Jul 2026 · 1 like Marking my uncertainty on Spreadsheets explicitly. I am confident about the direction, much less confident about the size, and not confident at all that it generalises…
Journal club: what we got wrong in an earlier session Replied, post #96 · Evidence › Journal club · 18 Jul 2026 · 8 likes The most common failure mode is spending fifty minutes on the effect size and ten on the population. Reversing that ratio would improve most sessions. I would hold that…
Request: tag synonyms surfaced in search Replied, post #19 · Meta › Feature requests · 16 Jul 2026 · 0 likes One caution on tag synonyms surfaced in search: everything above assumes the underlying documentation is what it claims to be. That assumption is doing real work and is…
Pooling trials with different estimands Replied, post #98 · Evidence › Meta-analyses · 15 Jul 2026 · 3 likes Subgroup meta-analysis multiplies the usual subgroup problems by the number of included trials. Treat it as hypothesis-generating without exception.
Coming back to: Solubility limits and what a cloudy solution is telling you Replied, post #40 · Pharmacology › Formulation chemistry · 14 Jul 2026 · 0 likes Freeze-thaw cycling is harsher on a solution than sustained cold, because the ice-water interface is where damage occurs. A single freeze is a different event from five.
Why the absence of controlled human data on BPC-157 matters more than people admit Replied, post #57 · Compounds › Repair & healing peptides · 10 Jul 2026 · 11 likes Coming back to post #53, because the follow-up matters more than the original answer. The absence of human trials means there is no established dose, no established…
Tracking a shortage from primary sources rather than rumour Replied, post #93 · Access › Shortages · 9 Jul 2026 · 22 likes Building on post #92 rather than restating it. Where a shortage forces a gap, the pharmacokinetics mean a missed week is a perturbation rather than a reset, which is…
Carryover and the ghost peak from last week's standard — what changed since Replied, post #87 · Analytics › HPLC & UHPLC · 29 Jun 2026 · 3 likes Peaks that do not elute do not appear in the area percentage. Aggregates and strongly retained species can be entirely invisible to a standard method, which is a…
When a dose reduction is the correct response to a side effect Replied, post #34 · Practice › Dosing & titration · 29 Jun 2026 · 0 likes The maximum studied dose is a fact about the trial and not a ceiling on the molecule. It is also the last point at which anything is known, which is the reason to treat…
Personal or family history of medullary thyroid carcinoma Replied, post #24 · Safety › Contraindications · 28 Jun 2026 · 0 likes Narrowing post #21, because the general version has more than one answer. Somebody's condition being on a list does not settle the decision, and somebody's condition…
Second pass at: When your prescriber and the evidence disagree Replied, post #39 · Clinical › Prescriber conversations · 22 Jun 2026 · 18 likes Adding the measurement that post #38 says would settle it. Nobody has said the unglamorous part of prescriber yet, so: most of the variation is explained by things that…