s.grigorescu
TL2 Member · Chania, GR
Practical questions, practical answers. Not interested in speculation without a source.
Joined 11 July 2025 · last posted 11d
73Posts here
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101Days visited
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Validating a method you did not develop — does this still hold? Replied, post #126 · Analytics › Method validation · 17 Mar 2025 · 33 likes I had written a reply contradicting post #124 and deleted it. Here is what survived. A stability-indicating method is one demonstrated to resolve the analyte from its…
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The 2.5 mg starting dose is not a therapeutic dose — why that matters Replied, post #113 · Compounds › Tirzepatide · 7 May 2026 · 32 likes On 2.5 mg starting dose, the part that usually goes wrong is that the question is asked as though it has one answer. It has a range, and the width of the range is the…
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Constipation management, with a dietitian's contribution Replied, post #56 · Practice › Side effects · 23 Apr 2026 · 32 likes The relationship between symptom burden and outcome is not what people assume. Feeling worse is not evidence of a larger effect and feeling nothing is not evidence of…
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Revisiting: The report format the maintainers ask for, and why each field is there Replied, post #83 · Sourcing › Vendor reports · 13 Jun 2026 · 30 likes Reports of ordinary results are more valuable than reports of remarkable ones, precisely because only the remarkable ones get posted elsewhere. Not the whole picture,…
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Heterogeneity as information rather than as a nuisance Replied, post #16 · Evidence › Meta-analyses · 5 Dec 2025 · 28 likes Where I have landed on heterogeneity, having got it wrong once in public: the direction is clear, the magnitude is not, and anyone quoting a precise magnitude has…
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Journal club: STEP 4 and what a withdrawal design can prove Replied, post #12 · Evidence › Journal club · 20 Mar 2025 · 24 likes What I would want before treating STEP 4 as settled: the method, the sample, and whether anyone tried to find the opposite result. Two of the three are usually missing.
Where this member posts
Badges earned, in order
| Badge | Tier | Granted |
|---|---|---|
| First Reply | bronze | 12 Jul 2025 |
| Basic User | bronze | 13 Jul 2025 |
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| Nice Post | bronze | 11 Sep 2025 |
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| Good Post | silver | 24 Dec 2025 |
| Anniversary | silver | 11 Jul 2026 |