s.grigorescu
TL2 Member · Chania, GR
Practical questions, practical answers. Not interested in speculation without a source.
Joined 11 July 2025 · last posted 11d
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Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile Replied, post #108 · Compounds › Semaglutide · 17 Jul 2026 · 10 likes Research-use-only semaglutide is not a licensed medicine, is not manufactured to pharmaceutical standards, and is not approved for human use. That is a statement about…
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Receptor desensitisation as a tolerance hypothesis, and its weak evidence Replied, post #38 · Pharmacology › Receptor biology · 8 Jul 2026 · 20 likes Receptor distribution explains the side-effect profile better than anything else. GLP-1 receptors in the gastrointestinal tract and the area postrema account for most…
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Personal or family history of medullary thyroid carcinoma Replied, post #11 · Safety › Contraindications · 24 Jun 2026 · 3 likes Picking up post #10: that is the part I would want checked first. A history of pancreatitis appears in the cautions and the decision around it needs somebody who knows…
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How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ — does this still hold? Replied, post #29 · Sourcing › Independent verification · 19 Jun 2026 · 11 likes Post #28 is the version of this I will quote in future. One addition. The useful distinction on Janoshik is between what was measured and what was inferred from it.…
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[2026 update] Travelling with an injectable: documentation and practicalities Replied, post #19 · Access › International · 16 Jun 2026 · 2 likes Both are useful and they are different contributions. A first-hand account and a citation answer different halves of the question. The strength of my opinion here…
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Coming back to: Why a preprint's supplementary material is often the best part Replied, post #79 · Evidence › Preprints · 14 Jun 2026 · 22 likes On post #75 — agreed on the reasoning, with one qualification. A preprint that has been up for two years without appearing in a journal is telling you something, and it…
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Revisiting: The report format the maintainers ask for, and why each field is there Replied, post #83 · Sourcing › Vendor reports · 13 Jun 2026 · 30 likes Reports of ordinary results are more valuable than reports of remarkable ones, precisely because only the remarkable ones get posted elsewhere. Not the whole picture,…
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Follow-up: Reading an interaction checker output critically Replied, post #4 · Practice › Interactions · 12 Jun 2026 · 6 likes Vitamins: most vitamins have no significant interaction. Fat-soluble vitamins (A, D, E, K) might be affected by the slowing of fat absorption during weight loss, but…
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Carryover and the ghost peak from last week's standard — what changed since Replied, post #23 · Analytics › HPLC & UHPLC · 11 Jun 2026 · 2 likes Retention time is only comparable within a laboratory on a given method. Quoting a retention time across two reports as evidence of identity is not a valid comparison.
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Heart failure with preserved ejection fraction: symptom endpoints Replied, post #2 · Clinical › Comorbidities · 11 Jun 2026 · 5 likes Seconded. It reads as careful rather than confident, which is the right register.
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Does a peptide degrade silently, with no visual change? Replied, post #42 · Practice › Storage & stability · 6 Jun 2026 · 3 likes That is clearer than the version I had in my head. Thank you.
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Blind submission and why it changes minds — the long version Replied, post #107 · Sourcing › Independent verification · 30 May 2026 · 21 likes That matches what I have seen, for whatever a single anecdote is worth.