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Clinical · Special populations · continued

Coming back to: Renal impairment: what the labelling says about dose posts 31–35

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

TK
t.kulkarniTL3Regular23 Jan 2025#31
MSaarinen, post #23: Post #19 and I disagree about the size of the effect, not about the direction. Being outside the studied population does not mean a treatment is unsafe. It means the usual evidence is not available and the reasoning has to be explicit. Go to post

Confirming post #30 from a second method, which matters more than confirming it from a second person.

Hypoglycemia risk: in people already on insulin or sulfonylureas, adding a GLP-1 agonist requires insulin dose reduction and close monitoring for hypoglycemia. This is manageable with attention.

I keep a log of this specifically because memory is unreliable about it.

0 likes in reply to #23 18mo
GO
g.oyelaranTL227 Jan 2025#32

I had written a reply contradicting post #28 and deleted it. Here is what survived.

Second-hand on Renal impairment, so weight it accordingly — someone whose method I trust told me this and I have not verified it myself.

0 likes 18mo
IL
integrator_logTL3Regular31 Jan 2025 · edited#33

The bit of Renal impairment that nobody enjoys is that the answer changes depending on what you are trying to decide with it. Say what the decision is and the thread will converge.

7 likes 18mo
JP
j.palaciosTL23 Feb 2025#34

The most useful contribution here is usually a citation to whichever published document comes closest, with a plain statement of how far it is from the question.

17 likes 18mo
V
VPoulsenTL3Regular7 Feb 2025#35
t.lindqvist, post #22: Hepatic impairment: less is known about dosing in significant liver disease than in kidney disease. Extreme caution applies because the liver metabolises a large fraction of many medications. One case, stated as one case. Go to post

My position on Renal impairment is current rather than settled. I have revised it once already and I expect to again, so treat it accordingly.

0 likes in reply to #22 18mo

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