Where a labelling document addresses a population explicitly, that text is the single most useful thing to quote in a thread.
A modest claim, modestly supported.
25 likes 22mo
Topic summary
Coming back to: Renal impairment: what the labelling says about dose
This is a generated summary. It shows the 5 most-liked posts from a topic of 35, in their original order, with the accepted answer included where one exists. It is a reading aid and it will miss nuance — the full topic is the record.
sharps_bin, post #7: Where a labelling document addresses a population explicitly, that text is the single most useful thing to quote in a thread. A modest claim, modestly supported. Go to post
Extrapolating a point estimate to somebody well outside the enrolled range should be described as an extrapolation every time it is done.
It is the kind of thing that is obvious once and never again.
j.vogel, post #13: Reading rather than contributing, but this is the most useful thread I have found on it. Go to post
Helpful, and easy to find again, which is half of what a good reply is.
MSaarinen, post #23: Post #19 and I disagree about the size of the effect, not about the direction. Being outside the studied population does not mean a treatment is unsafe. It means the usual evidence is not available and the reasoning has to be explicit. Go to post
This follows post #27 rather than contradicting it.
Nothing in this subcategory is medical advice and the questions asked here are precisely the ones that need an individual assessment.
Read the full topic (35 posts)
This topic was referenced in
- Renal impairment: what the labelling says about doseClinical › Special populations · 4 replies
- Adolescents: a distinct evidence base — one year onClinical › Special populations · 88 replies
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