Confirming the opening post from a second method, which matters more than confirming it from a second person.
A collapsed cake indicates the product warmed above its collapse temperature during drying. It is not necessarily a quality failure and it is a real observation about the process.
Caveat: everything above assumes the paperwork is what it says it is.
Adding a reference point for Lyophilisation. Mine is a single case, collected without controls, and I am posting the method alongside it so it can be discounted appropriately.
Buffer choice affects both solubility and stability, and the two do not always point the same way. A formulation is a compromise between them rather than an optimum for either.
Post #14 answers the question as asked. The question underneath it is different.
On Lyophilisation I would separate what is worth knowing from what is worth acting on. The first list is long and the second is short, and conflating them is how threads get heated.
Read the full topic (15 posts)
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Excipient function in a licensed injectable — the long version
Posting this under the heading it deserves: Excipient function in a licensed injectable — the long version Everything below is what sits behind that. A narrow question about Excipient function, deliberately…
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2 | 100 | 15mo | |
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Preservatives: function, testing, and limits
Preservatives: function, testing, and limits — setting out what I have, and where I think it stops being reliable. An honest uncertainty about preservatives rather than a disguised assertion. I do not know…
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+23 | 27 | 3.7k | 16mo |
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Preservatives: function, testing, and limits — one year on
On the subject in the title: Preservatives: function, testing, and limits — one year on Working notes rather than a conclusion. Asking about Preservatives directly, because I have read four threads on it and…
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+28 | 32 | 437 | 8d |
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Coming back to: Solubility limits and what a cloudy solution is telling you
On the subject in the title: Solubility limits and what a cloudy solution is telling you Working notes rather than a conclusion. Reading back through what has been written here about Solubility limits, three…
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+38 | 43 | 29k | 13h |
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[2026 update] Buffers, pH and why a formulation is a formulation
Posting this under the heading it deserves: Buffers, pH and why a formulation is a formulation Everything below is what sits behind that. A formulation question rather than a pharmacological one, though the…
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2 | 773 | 3mo |
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[2026 update] Buffers, pH and why a formulation is a formulation
Posting this under the heading it deserves: Buffers, pH and why a formulation is a formulation Everything below is what sits behind that. A formulation question rather than a pharmacological one, though the…
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2 | 773 | 3mo | |
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Temperature logging at home: what is worth the effort
Temperature logging at home: what is worth the effort — setting out what I have, and where I think it stops being reliable. An honest uncertainty about temperature logging rather than a disguised assertion. I…
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2 | 6.3k | 7mo | |
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Adsorption to container surfaces and to plastics
On the subject in the title: Adsorption to container surfaces and to plastics Working notes rather than a conclusion. I was wrong about adsorption in a thread last spring and I would like to correct it…
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+13 | 17 | 4.3k | 5mo |
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Freeze-thaw and why one cycle is not the same as five
On the subject in the title: Freeze-thaw and why one cycle is not the same as five Working notes rather than a conclusion. Two things I would like separated before anyone answers on freeze-thaw, because they…
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+21 | 25 | 41k | 8mo |
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Coming back to: Reconstitution volumes that produce round numbers, tabulated
On the subject in the title: Reconstitution volumes that produce round numbers, tabulated Working notes rather than a conclusion. Writing this out with the numbers in it, because "roughly" is how these go…
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2 | 24k | 6mo |