A note on how mass-error checker gets discussed rather than on mass-error checker itself: the confident posts get the replies and the careful ones get ignored, and the careful ones have been right more often.
The mass-error checker and its intended scope posts 121–150
This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.
Post #122 is right about the mechanism and I think understates the practical bit.
Significant figures in the output should not exceed what the inputs support. A concentration calculated from a nominal vial mass is not known to four decimal places.
My position on mass-error checker is current rather than settled. I have revised it once already and I expect to again, so treat it accordingly.
Where the mass-error checker discussion usually stalls is that nobody wants to say "I do not know" and everyone is willing to say "it varies". Those are the same sentence with different clothes on.
Reading back through, this was answered upthread and I missed it. My fault.
I had written a reply contradicting post #124 and deleted it. Here is what survived.
The parts-per-million mass-error calculation is simple enough to do mentally to one significant figure, which is a good habit because it catches an order-of-magnitude slip immediately.
The arithmetic in post #126 is right; the assumption feeding it is the part to check.
Dose equivalence calculator: compounds have different potencies. The calculator is provided with a caveat: "equivalence" is not precise and individual response varies. It is a rough starting point, not a dose prescription.
Mass-error checker looks different depending on whether you are reading the primary literature or the summaries of it, and the difference is not in our favour.
That is clearer than the version I had in my head. Thank you.
Worth separating two things that post #131 runs together.
The most common input error is entering the vial mass in the concentration field. It produces a plausible number, which is why it survives.
I have no interest in any supplier named above.
Unit-conversion tools are only as good as the assumption they make about the syringe. Ask what barrel and what graduation interval it assumed before trusting the units figure.
The general answer and the answer for your case may diverge here.
What I would want before treating mass-error checker as settled: the method, the sample, and whether anyone tried to find the opposite result. Two of the three are usually missing.
Collapsed as off-topic by two members at trust level 3 or above
Post #135 is right about the mechanism and I think understates the practical bit.
Reading back through the mass-error checker threads from last year, the same three questions come up every time and only one of them has ever been answered properly. That seems like a documentation gap rather than a knowledge gap.
Picking up post #139: that is the part I would want checked first.
Mass-error checker is well covered in the tag pages, and the older discussions are better than the recent ones because they were argued out properly. Worth twenty minutes before adding to this one.
Worth separating two things that post #139 runs together.
Dose equivalence calculator: compounds have different potencies. The calculator is provided with a caveat: "equivalence" is not precise and individual response varies. It is a rough starting point, not a dose prescription.
If anyone can point at the primary source I would be grateful.
Post #140 is right about the mechanism and I think understates the practical bit.
Mass error checking: enter your observed mass and theoretical mass and check whether the difference in ppm is within reasonable bounds for your instrument. Useful sanity check on LC-MS results.
The calculators maintained on this site are open-source and verifiable. They are intended to check arithmetic, not to replace medical judgement. Using them is optional and they are provided for convenience.
Picking up post #144: that is the part I would want checked first.
On mass-error checker the community has more anecdote than the confidence in this thread implies, and I include my own contribution in that.
A calculator that shows its working is worth ten that give an answer. The whole value is being able to see which step you disagree with.
Small methodological point on mass-error checker: repeating a measurement is cheap and resolves most of what is being argued about here at no cost to anyone.
The reason mass-error checker keeps being re-asked is that the answer is conditional and people quote it without the condition. It is not that the answer is unknown.