On alcohol: the labelling does not contraindicate it, but it raises gastric irritation risk and semaglutide already does that. There is no published interaction study and the conservative position is to limit it if you are titrating or if gastrointestinal symptoms are troublesome. That is my reading. Someone else…
What the published dose-response for semaglutide actually looks like above 2.4 mg — that is the question, and I have not found it answered plainly anywhere I have looked.
I would like to know what people here actually do about published dose-response for semaglutide, as distinct from what is usually recommended. Those have diverged in every other subject I have looked at closely.
Mine is below, with the reasoning, including the parts I am not confident about.
On alcohol: the labelling does not contraindicate it, but it raises gastric irritation risk and semaglutide already does that. There is no published interaction study and the conservative position is to limit it if you are titrating or if gastrointestinal symptoms are troublesome.
That is my reading. Someone else read the same page differently and was reasonable.
The C-cell question: semaglutide triggered medullary thyroid carcinoma in rodent toxicology studies. A signal in rodents does not automatically appear in humans, but it is the reason the compound is contraindicated in people with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2.
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Molecular mass of semaglutide and why the figure differs between sources — does this still hold?
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+94 | 102 | 14k | 19mo |
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Follow-up: Semaglutide versus liraglutide head to head: reading STEP 8 carefully
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+1 | 5 | 11k | 20mo |
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Revisiting: Is there a ceiling dose beyond which semaglutide stops adding benefit?
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+5 | 9 | 30k | 8d |
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Semaglutide and gastric emptying — the mechanism behind most of the side-effect profile
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+115 | 122 | 2.6k | 1d |
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Semaglutide and alcohol: what is actually documented
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+14 | 18 | 10k | 2d |
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How to read a phase 2 result without treating it as a phase 3 result
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+36 | 40 | 35k | 7mo |
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Journal club: STEP 3 and the intensive behavioural therapy floor
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+6 | 10 | 13k | 28d |
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Coming back to: An 18-month record including the parts that went badly
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+83 | 89 | 52k | 12mo |
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Getting a referral rather than a refusal
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+8 | 12 | 32k | 2mo |
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About the Statistics category
Effect sizes, intervals, multiplicity, and the difference between absent and undetected. This post is a community wiki: any member at trust level 3 or above can edit it, and every edit is recorded with its…
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+4 | 8 | 2.3k | 7mo |