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Top topics — all time page 16

Ranked by replies, likes and views over all time, with a bonus for topics that reached a marked solution. Engagement is a proxy for usefulness and a poor one; the documentation commons is the better index of what is settled.

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1,535 topics · page 16 of 40

Topic	Participants	Replies	Views	Activity
Follow-up: Comparing two chromatograms from different laboratories, properly Analytics › HPLC & UHPLC gradient method system suitability HPLC peak integration Comparing two chromatograms from different laboratories, properly — setting out what I have, and where I think it stops being reliable. I would like to understand what this number means before I repeat it…	+62	67	12k	9h
A single out-of-range value on an otherwise normal panel Clinical › Bloodwork lipid panel HbA1c liver enzymes lipase & amylase Posting this under the heading it deserves: A single out-of-range value on an otherwise normal panel Everything below is what sits behind that. General question, not a request for advice about my own care — I…	+70	75	20k	6d
Revisiting: Drawing up with one needle and injecting with another Practice › Administration subcutaneous injection injection site reaction needle gauge & length missed dose Revisiting: Drawing up with one needle and injecting with another Writing it up because I had to work it out twice and would rather nobody else did. A practical question that I suspect has a boring answer,…	+76	83	1.1k	4mo
Biased agonism: a real phenomenon, an over-used explanation — what changed since Pharmacology › Receptor biology amylin analogues tirzepatide retatrutide long read Biased agonism: a real phenomenon, an over-used explanation — what changed since — setting out what I have, and where I think it stops being reliable. What changes if the standard account of Biased agonism is…	+49	56	47k	17mo
Search filters: what is missing Meta › Site feedback site feedback moderation guidelines Search filters: what is missing — setting out what I have, and where I think it stops being reliable. Search filters — I have the observation and I do not trust my interpretation of it, so I am posting the…	+72	84	15k	3d
Fatigue in the first month: how much is the drug and how much is intake — what changed since Practice › Side effects nausea constipation hair shedding Closed Fatigue in the first month: how much is the drug and how much is intake — what changed since Writing it up because I had to work it out twice and would rather nobody else did. Something changed and I would…	+77	82	1.2k	11mo
Semaglutide versus liraglutide head to head: reading STEP 8 carefully Compounds › Semaglutide STEP programme SELECT trial randomised trial type 2 diabetes Under review On the subject in the title: Semaglutide versus liraglutide head to head: reading STEP 8 carefully Working notes rather than a conclusion. I would like to disagree carefully with the settled view on…	+72	81	1.5k	9mo
Follow-up: Bug report: the reconstitution calculator and a rounding edge case Data & Tools › Calculators concentration maths site feedback syringe units On the subject in the title: Bug report: the reconstitution calculator and a rounding edge case Working notes rather than a conclusion. Posting the calculation with the inputs, so that somebody can disagree…	+58	63	24k	5mo
[2026 update] Citation sweep results: how many references did not say what was claimed Meta › Wiki maintenance maintainership review date moderation citation check Citation sweep results: how many references did not say what was claimed Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of Citation…	+41	45	47k	12mo
Follow-up: Tesamorelin has an approved indication — what that changes about the evidence Compounds › Secretagogues & GH axis CJC-1295 needs a source tesamorelin observational data Posting this under the heading it deserves: Tesamorelin has an approved indication — what that changes about the evidence Everything below is what sits behind that. What changes if the standard account of…	+63	68	18k	14mo
Subgroup analyses: pre-specified versus discovered — a second dataset Evidence › Trials open label discontinuation & dropout estimand randomised trial On the subject in the title: Subgroup analyses: pre-specified versus discovered — a second dataset Working notes rather than a conclusion. Posting a small dataset on Subgroup analyses. It is mine, it is…	+71	79	906	3mo
Individual participant data versus aggregate data Evidence › Meta-analyses heterogeneity risk of bias meta-analysis publication bias Posting this under the heading it deserves: Individual participant data versus aggregate data Everything below is what sits behind that. Something about individual participant data versus aggregate does not…	+30	34	64k	14mo
Sleep quality changes during weight loss — what changed since Wellbeing › Sleep obstructive sleep apnoea heart rate fatigue Sleep quality changes during weight loss — what changed since Writing it up because I had to work it out twice and would rather nobody else did. What changes if the standard account of Sleep quality changes…	+68	74	10k	8mo
Nausea profile of amylin analogues compared with GLP-1 agonists Compounds › Cagrilintide & amylin analogues cagrilintide amylin analogues cagrisema Nausea profile of amylin analogues compared with GLP-1 agonists Writing it up because I had to work it out twice and would rather nobody else did. I have spent a fortnight trying to pin nausea profile of…	+70	76	3k	4mo
Prior authorisation: what the criteria usually require — a second dataset Access › Insurance & coverage prior authorisation insurance formulary appeals Posting this under the heading it deserves: Prior authorisation: what the criteria usually require — a second dataset Everything below is what sits behind that. Posting a small dataset on Prior authorisation.…	+67	74	19k	21h
Requesting a page: what makes a good request Documentation › Wiki requests wiki post maintainership promoted to docs review date Requesting a page: what makes a good request Writing it up because I had to work it out twice and would rather nobody else did. Trying to work out what would count as evidence on requesting a page, before…	+65	71	9.3k	15mo
Completing a dose with a second syringe, and the dead-volume arithmetic Practice › Administration aseptic technique subcutaneous injection missed dose needle gauge & length Wiki Posting this under the heading it deserves: Completing a dose with a second syringe, and the dead-volume arithmetic Everything below is what sits behind that. I have read the maintained page on this and I…	+65	76	7.4k	1d
Cost per delivered dose, which is the number that matters Access › Pricing cost per milligram data table compounding formulary Solved Cost per delivered dose, which is the number that matters — setting out what I have, and where I think it stops being reliable. Documenting an access outcome, dated, because everything in this category…	+54	59	30k	4mo
Older adults, sarcopenia risk, and the trade-off nobody quantifies — the long version Clinical › Special populations older adults chronic kidney disease adolescents disordered eating Older adults, sarcopenia risk, and the trade-off nobody quantifies — the long version — setting out what I have, and where I think it stops being reliable. A narrow question about Older adults, deliberately…	+64	69	15k	7mo
What pooling buys you and what it destroys Evidence › Meta-analyses publication bias risk of bias meta-analysis heterogeneity Solved The question in the title: What pooling buys you and what it destroys I will give what I have already checked below so nobody repeats it. The question about pooling buys that I actually want answered is the…	+74	83	6.6k	8mo
Reporting a disappointing outcome, and why it belongs here Outcomes › Progress reports data table DXA effect size Closed Reporting a disappointing outcome, and why it belongs here Writing it up because I had to work it out twice and would rather nobody else did. Proposing that reporting a disappointing outcome deserves a…	+21	29	62k	10mo
A widely repeated interaction claim that turns out to be unsupported Practice › Interactions metformin hypoglycaemia delayed gastric emptying needs a source On the subject in the title: A widely repeated interaction claim that turns out to be unsupported Working notes rather than a conclusion. I was wrong about widely repeated interaction claim in a thread last…	+47	51	37k	3mo
Adducts: sodium, potassium, and the peak you did not expect Analytics › Mass spectrometry LC-MS MALDI-TOF mass error (ppm) Wiki Adducts: sodium, potassium, and the peak you did not expect Writing it up because I had to work it out twice and would rather nobody else did. Adducts keeps being re-asked here and I think that is because the…	+70	77	3.5k	15mo
Storing lyophilised material long term: what governs the shelf life Practice › Storage & stability temperature excursion cold chain freeze-thaw On the subject in the title: Storing lyophilised material long term: what governs the shelf life Working notes rather than a conclusion. I have spent a fortnight trying to pin storing lyophilised material…	+83	90	1k	5mo
Oral contraceptives and delayed emptying: what the data shows Practice › Interactions metformin delayed gastric emptying insulin Solved Posting this under the heading it deserves: Oral contraceptives and delayed emptying: what the data shows Everything below is what sits behind that. The question about oral contraceptives and delayed emptying…	+63	71	5.9k	2y
Reading a rodent study on a secretagogue without over-extrapolating Compounds › Secretagogues & GH axis observational data GHRP class CJC-1295 needs a source Closed Posting this under the heading it deserves: Reading a rodent study on a secretagogue without over-extrapolating Everything below is what sits behind that. Reading a rodent study, and specifically the version…	+50	54	32k	10mo
Lyophilisation and why the cake looks the way it does Pharmacology › Formulation chemistry sterile water bacteriostatic water storage cloudy or discoloured solution Posting this under the heading it deserves: Lyophilisation and why the cake looks the way it does Everything below is what sits behind that. I was wrong about lyophilisation in a thread last spring and I…	+33	37	60k	6mo
Insomnia at a dose step: reported experiences — the long version Wellbeing › Sleep obstructive sleep apnoea heart rate fatigue Solved Pinned Insomnia at a dose step: reported experiences — the long version Writing it up because I had to work it out twice and would rather nobody else did. A sleep question with what I actually recorded rather than…	+47	51	31k	1d
Revisiting: Moderation log format change Meta › Announcements guidelines trust levels moderation site feedback Revisiting: Moderation log format change Writing it up because I had to work it out twice and would rather nobody else did. Moderation log format change keeps being re-asked here and I think that is because…	+65	71	9.1k	19mo
Why pulsatile secretion matters for interpreting secretagogue claims — a second dataset Compounds › Secretagogues & GH axis GHRP class ipamorelin tesamorelin Under review The question in the title: Why pulsatile secretion matters for interpreting secretagogue claims — a second dataset I will give what I have already checked below so nobody repeats it. Posting a small dataset…	+60	64	25k	15mo