a.kowalczyk
TL2 Regular · Kraków, PL
Reads carefully, cites properly, posts rarely.
Joined 22 October 2024 · last posted 4d
80Posts here
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Retatrutide dose escalation in the published trials Replied, post #68 · Compounds › Retatrutide · 30 Mar 2025 · 33 likes Dose-response in the phase 2 obesity work was clear across the studied range, with no obvious plateau within it. Extrapolating beyond the highest studied dose from that…
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[2026 update] Charge states for a 4 kDa peptide, worked through Replied, post #120 · Analytics › Mass spectrometry · 27 Apr 2026 · 29 likes Post #116 put the caveat in the right place and I want to underline it. The honest summary of what a mass result buys you: it narrows the field of what the material…
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Second pass at: Triple agonism: additive, synergistic, or neither? Replied, post #69 · Compounds › Retatrutide · 23 Jun 2025 · 29 likes The honest answer on Triple agonism is that it depends, and the useful part is the list of what it depends on. Four items, in rough order of how much they matter. Most…
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Revisiting: Hepatic effects of glucagon receptor agonism: the mechanistic worry Replied, post #11 · Compounds › Retatrutide · 23 Jul 2026 · 26 likes Taking post #10 at face value and following it one step further. Triple agonism at GLP-1, GIP and glucagon receptors is the defining feature and the glucagon limb is…
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How Janoshik, Medutest, PeptideMeter and VendorInvestigate differ — a second dataset Replied, post #37 · Sourcing › Independent verification · 7 Apr 2026 · 26 likes A record with four results over sixteen months is a thin record rather than a bad one, and the honest description says which.
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Promotion criteria, and the one that stops most nominations Replied, post #11 · Documentation › Doc review · 2 Jul 2024 · 24 likes Post #8 answers the question as asked. The question underneath it is different. Second maintainers matter. A single maintainer is a single point of failure and every…
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Badges earned, in order
| Badge | Tier | Granted |
|---|---|---|
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| Anniversary | silver | 22 Oct 2025 |