o.pasquale
TL1 Member · Dijon, FR
Newer member working through the reference pages before asking anything.
Joined 9 November 2025 · last posted 13h
30 posts, newest first. Showing up to 150.
-
Coming back to: Solubility limits and what a cloudy solution is telling you Replied, post #44 · Pharmacology › Formulation chemistry · 27 Jul 2026 · 0 likes Having read the whole Solubility limits thread before replying: the question in the first post has not actually been answered yet, and three of us have answered a…
-
A widely repeated interaction claim that turns out to be unsupported — what changed since Replied, post #91 · Practice › Interactions · 22 Jul 2026 · 12 likes Taking post #90 at face value and following it one step further. Separation timing versus clinically important interaction: a separation timing inconvenience (taking…
-
Stepping down deliberately, and how to do it without losing progress — what changed since Replied, post #58 · Practice › Dosing & titration · 12 Jul 2026 · 0 likes Concentration and dose get conflated constantly in this subcategory. Changing how much diluent you add changes the volume you draw and changes nothing about the dose.
-
A critique that turned out to be unfair, retracted by its author Replied, post #24 · Evidence › Study critique · 4 Jul 2026 · 5 likes Criticise the method, not the author: a paper with a weak design is not a bad paper by someone with bad intentions. It is a paper that answers a limited question.…
-
Journal club: what we got wrong in an earlier session Replied, post #24 · Evidence › Journal club · 23 Jun 2026 · 0 likes On post #22 — agreed on the reasoning, with one qualification. Worth starting from what the authors set out to estimate rather than what they reported. Half the…
-
Joined after a search result and stayed Replied, post #7 · Lounge › Introductions · 20 Jun 2026 · 24 likes Coming in from the clinical side and slightly wary of the register. I have read enough to see that "not medical advice" is meant here rather than pasted, which is why I…
-
Follow-up: Reading an interaction checker output critically Replied, post #11 · Practice › Interactions · 19 Jun 2026 · 30 likes Following this. I have the same question and no better information than the first post.
-
Why cagrilintide alone is discussed so much less than in combination — does this still… Replied, post #8 · marked as the solution · Compounds › Cagrilintide & amylin analogues · 13 Jun 2026 · 6 likes Published human data on cagrilintide alone is thinner than on the combination, which is the reverse of what most people assume from how it is discussed here. Small…
-
Prescription requirements and telehealth models — a second dataset Replied, post #22 · Sourcing › Regulatory · 7 May 2026 · 10 likes Answering the Prescription requirements and telehealth models question as asked, then the question I think is meant. As asked: yes, with the qualification below. As…
-
Introducing myself: pharmacist, sceptic, reluctant participant — one year on Replied, post #91 · Lounge › Introductions · 17 Mar 2026 · 0 likes If you are arriving from somewhere louder, the pace here will feel slow. A topic can sit for two days and then get a reply that is worth the wait. That is the design…
-
Semaglutide half-life: where the 165 to 184 hour figure comes from Replied, post #123 · Compounds › Semaglutide · 19 Feb 2026 · 7 likes An honest declaration on semaglutide half-life: I have a prior here and it is strong enough that you should weight what I say downward. Stating it rather than hiding it.
-
Comparing my trajectory with the trial curves, carefully — a second dataset Started this topic · Outcomes › Progress reports · 14 Jan 2026 · 47 likes Comparing my trajectory with the trial curves, carefully — a second dataset — setting out what I have, and where I think it stops being reliable. Maintenance rather…
-
What "verified" means on our vendor pages, stated narrowly Replied, post #20 · Sourcing › Vendor reports · 30 Dec 2025 · 0 likes Dosing and purity: a vial that is 99% pure might contain 80% of its label claim if the other mass is water, counter-ion, and excipient. Purity and content are…
-
Coming back to: Feature request: should a dose-equivalence tool exist at all? Replied, post #10 · marked as the solution · Data & Tools › Calculators · 17 Nov 2025 · 7 likes Post #8 is the version of this I will quote in future. One addition. Do the arithmetic by hand the first few times, whatever tool you use afterwards. A calculator with…
-
What happens after your first post: likes, trust levels, and why none of it matters much… Replied, post #64 · Start Here › Welcome · 18 Oct 2025 · 0 likes Asking as the newest person in the thread: is there a canonical order to read the documentation set in? I have been going alphabetically and that is clearly not it.
-
Reverse causation in a cohort study of weight and outcome — a second dataset Replied, post #108 · Evidence › Study critique · 16 Sep 2025 · 20 likes Post #107 put the caveat in the right place and I want to underline it. The useful distinction on Reverse causation is between what was measured and what was inferred…
-
Second pass at: LOD and LOQ: definitions people get wrong Replied, post #29 · Analytics › Method validation · 3 Sep 2025 · 4 likes Picking up post #26: that is the part I would want checked first. LOD and LOQ would be much easier to settle if anyone reported the denominator. Almost nobody reports…
-
Power cut for eleven hours: how I assessed it afterwards Replied, post #41 · Practice › Storage & stability · 31 Aug 2025 · 12 likes Adding the measurement that post #39 says would settle it. Temperature excursions: if a vial sat at room temperature for a time, the question is whether the excursion…
-
What this community means by "a source", in practical terms Replied, post #78 · Start Here › Welcome · 19 Aug 2025 · 1 like Joining rather than answering. I have read the orientation set twice and the thing that finally made it click was realising the documentation pages are the destination…
-
Which panel is worth repeating and which is worth ignoring Replied, post #84 · Clinical › Bloodwork · 13 Aug 2025 · 11 likes Marking my uncertainty on panel explicitly. I am confident about the direction, much less confident about the size, and not confident at all that it generalises past…
-
[2026 update] What we do not know about retatrutide, listed explicitly Replied, post #21 · Compounds › Retatrutide · 24 Jul 2025 · 13 likes Nausea and vomiting were dose-related in the phase 2 work, as they are throughout this class. What is not established is whether the tolerability profile differs from…
-
A 5 mg vial and a 0.25 mg dose: the arithmetic in full — the long version Replied, post #137 · Practice › Reconstitution · 16 Jun 2025 · 5 likes A note on scope: what I am saying about 5 mg vial applies to the case in the first post and I would not extend it further without checking.
-
Validating a calculator against hand arithmetic — what changed since Replied, post #100 · Data & Tools › Calculators · 30 May 2025 · 1 like Unit-conversion tools are only as good as the assumption they make about the syringe. Ask what barrel and what graduation interval it assumed before trusting the units…
-
A well-designed study with a badly written abstract Replied, post #58 · Evidence › Study critique · 3 May 2025 · 0 likes Building on post #57 rather than restating it. Per-protocol and intention-to-treat analyses answer different questions and neither is the honest one by default.…
-
Introducing myself and asking whether my planned first topic belongs anywhere Replied, post #6 · Start Here › Welcome · 15 Feb 2025 · 0 likes Do not feel obliged to reply to every reply on your own topic. A single "that answered it" and a marked solution is the most useful thing you can do for the next person…
-
Revisiting: How to bring a laboratory report to an appointment usefully Replied, post #96 · Clinical › Bloodwork · 10 Oct 2024 · 0 likes Adding the boring version of bring a laboratory, because the interesting version keeps getting posted and the boring one is usually right. Check the ordinary…
-
Why I ask for the gradient before I discuss the number Replied, post #26 · Analytics › HPLC & UHPLC · 8 Oct 2024 · 7 likes Fine by me. I had wanted a stronger conclusion and there is not one available.
-
Correlation in a self-tracked dataset: what it can support Replied, post #144 · Research Methods › Statistics · 25 Aug 2024 · 9 likes Bayesian and frequentist analyses answer different questions and both are legitimate. What matters is that the reader knows which is on offer. Where I would look next,…
-
Guidelines revision: what changed and why Replied, post #114 · Meta › Announcements · 28 Jul 2024 · 0 likes Post #113 is the version of this I will quote in future. One addition. Since guidelines revision keeps coming up, it should probably be a maintained page rather than a…
-
Two sessions a week versus four: what the evidence supports — a second dataset Replied, post #16 · Nutrition & Training › Resistance training · 23 Jun 2024 · 0 likes Post #14 describes the usual case. This is about the unusual one. Anybody returning after a break should expect to start lower than they left, and expecting otherwise…