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Access · Pricing · continued

Cost per milligram, computed honestly across formats — the long version posts 61–90

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1.

O
OkaforTL3Regular10 Apr 2025#61
t.steenkamp, post #39: Compute cost per delivered dose at your dose if you want a number you can act on. Everything else is a comparison of packaging. The short answer was in the first line; everything after is the working. Go to post

Insurance tier placement: a compound might be covered but on a higher tier (higher copay). Moving to a lower tier usually requires prior authorization or documented failure of cheaper alternatives.

0 likes in reply to #39 16mo
FI
f.ibarraTL211 Apr 2025#62

The arithmetic in post #61 is right; the assumption feeding it is the part to check.

Nothing here is financial advice and none of it is a route to a transaction.

0 likes 16mo
ID
integrator_draftTL3Regular12 Apr 2025#63

Post #61 put the caveat in the right place and I want to underline it.

Pharmacy acquisition cost: a pharmacy pays less than the patient pays, even at insurance rates. That margin is where the pharmacy's costs and profit live.

The number is defensible. The precision I gave it is not.

18 likes 16mo
NS
n.szaboTL213 Apr 2025 · edited#64
il.dumitru, post #55: This is the first time the answer has come with its own limits attached. Appreciated. Go to post

The cost of an independent submission is worth stating in these threads, because it is the main reason people do not do it.

The strength of my opinion here exceeds the strength of my evidence.

7 likes in reply to #55 15mo
VK
v.klausenTL3Regular14 Apr 2025#65

That is consistent with mine, for whatever one more account is worth.

0 likes 15mo
EC
e.coelhoTL215 Apr 2025#66

The most useful pricing posts here are the ones that show the arithmetic rather than the conclusion.

25 likes 15mo
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GDashwoodTL3Regular16 Apr 2025#67

Post #66 and I disagree about the size of the effect, not about the direction.

Pharmacy acquisition cost: a pharmacy pays less than the patient pays, even at insurance rates. That margin is where the pharmacy's costs and profit live.

12 likes 15mo
CH
ca.haddadTL217 Apr 2025#68
OTeixeira, post #52: Independent testing is a real cost and belongs in the comparison. A cheaper supplier tested every lot may cost more in total. I have kept the units in throughout, for the obvious reason. Go to post

Taking post #66 at face value and following it one step further.

Insurance tier placement: a compound might be covered but on a higher tier (higher copay). Moving to a lower tier usually requires prior authorization or documented failure of cheaper alternatives.

That distinction has done more work for me than anything else in this category.

4 likes in reply to #52 15mo
GI
g.ibarraTL218 Apr 2025#69
e.roos, post #59: Picking up post #58: that is the part I would want checked first. The most useful pricing posts here are the ones that show the arithmetic rather than the conclusion. Go to post

I read post #66 twice before replying, because I had assumed the opposite.

Compute cost per delivered dose at your dose if you want a number you can act on. Everything else is a comparison of packaging.

The disagreement above is smaller than it looks once the terms are fixed.

0 likes in reply to #59 15mo
JT
j.teixeiraTL219 Apr 2025#70
e.lehtinen, post #44: The most useful pricing posts here are the ones that show the arithmetic rather than the conclusion. Go to post

Cost per milligram is the only comparison that survives format differences, and even then it needs care.

Nothing above should be read as advice about what anyone else should do.

18 likes in reply to #44 15mo
SM
s.mbekiTL219 Apr 2025#71
il.dumitru, post #55: This is the first time the answer has come with its own limits attached. Appreciated. Go to post

Nothing here is financial advice and none of it is a route to a transaction.

12 likes in reply to #55 15mo
NA
n.abernathyTL3Analytical chemist20 Apr 2025#72

The most useful pricing posts here are the ones that show the arithmetic rather than the conclusion.

26 likes 15mo
AV
a.vukovicTL221 Apr 2025#73

Fair, and the limits you put on it are the part I will remember.

19 likes 15mo
RA
r.aldana_pharmdTL4Pharmacist22 Apr 2025#74

Post #70 put the caveat in the right place and I want to underline it.

The cost of an independent submission is worth stating in these threads, because it is the main reason people do not do it.

Anyone with a larger sample, please post it.

0 likes 15mo
KP
k.perrinTL223 Apr 2025#75
e.coelho, post #66: The most useful pricing posts here are the ones that show the arithmetic rather than the conclusion. Go to post

The most useful pricing posts here are the ones that show the arithmetic rather than the conclusion.

0 likes in reply to #66 15mo
BN
bench_notesTL4 Moderator24 Apr 2025#76

I read post #74 twice before replying, because I had assumed the opposite.

Wastage from a concentration choice that leaves an unusable remainder is a real cost and is invisible in a per-milligram figure.

Second-hand, so weight it accordingly.

4 likes 15mo
KF
k.fonsecaTL225 Apr 2025#77
KV
k.vanheckeTL226 Apr 2025 · edited#78
s.oyelaran, post #51: Landed cost including shipping, fees and currency conversion is what you actually pay, and quotes that look identical frequently are not. Not the answer, but possibly the question that gets there. Go to post

Nothing here is financial advice and none of it is a route to a transaction.

It reads as pedantry until the day it does not.

27 likes in reply to #51 15mo
RV
r.villalobosTL226 Apr 2025#79

Post #76 is right about the mechanism and I think understates the practical bit.

Where somebody posts a comparison, the useful version states the date, the region and what was included.

I would want a second opinion before relying on that.

0 likes 15mo
RD
r.danquahTL227 Apr 2025#80
RM
r.mcalisterTL3Regular28 Apr 2025#81
k.fonseca, post #77: Taking post #76 at face value and following it one step further. A cheaper option that arrives slowly has a cost in the form of running out, and people rarely price that. Posting it because the silence on this was starting to look like agreement. Go to post

Cost per milligram is the only comparison that survives format differences, but even then it needs care. A pen and a vial are not the same product and cannot be compared on price per milligram alone because dead volume, wastage, and number of doses actually obtainable differ.

That holds under the stated conditions and I have stated them.

0 likes in reply to #77 15mo
AI
a.iyerTL229 Apr 2025#82

Insurance tier placement: a compound might be covered but on a higher tier (higher copay). Moving to a lower tier usually requires prior authorization or documented failure of cheaper alternatives.

Same conclusion as the reply above, reached differently, which is mildly reassuring.

1 like 15mo
FD
f.demirTL2Regular30 Apr 2025 · edited#83

Where I part company with post #79, and it is a narrow parting.

Nothing here is financial advice and none of it is a route to a transaction.

10 likes 15mo
MS
m.steinerTL21 May 2025#84
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bias_varianceTL4Biostatistician2 May 2025#85
n.abernathy, post #72: The most useful pricing posts here are the ones that show the arithmetic rather than the conclusion. Go to post

Post #83 describes the usual case. This is about the unusual one.

Insurance tier placement: a compound might be covered but on a higher tier (higher copay). Moving to a lower tier usually requires prior authorization or documented failure of cheaper alternatives.

0 likes in reply to #72 15mo
SO
s.ostergaardTL23 May 2025#86

Nothing here is financial advice and none of it is a route to a transaction.

I have changed my mind on this once already, so take it as current rather than settled.

23 likes 15mo
IT
impurity_tableTL3Analytical chemist3 May 2025#87

Thank you — that answers what I came here to find out.

6 likes 15mo
HD
h.delgadoTL24 May 2025#88

Confirming post #86 from a second method, which matters more than confirming it from a second person.

Cost per week at a maintenance dose is the figure most people actually want and least often calculate.

1 like 15mo
CR
compounding_ruthTL4Pharmacist5 May 2025#89

On post #88 — agreed on the reasoning, with one qualification.

Insurance tier placement: a compound might be covered but on a higher tier (higher copay). Moving to a lower tier usually requires prior authorization or documented failure of cheaper alternatives.

32 likes 15mo
NL
n.laurentTL26 May 2025#90

Picking up post #88: that is the part I would want checked first.

Landed cost including shipping, fees and currency conversion is what you actually pay, and quotes that look identical frequently are not.

16 likes 15mo