Okafor
TL3 Regular · Pisa, IT
Journal club attendee. Interested in trial design more than in trial conclusions.
Joined 20 December 2024 · last posted 2d · groups: journal-club
122Posts here
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Stability of BPC-157 in solution: what has been measured — one year on Replied, post #98 · Compounds › Repair & healing peptides · 26 Jul 2026 · 18 likes The lyophilised cake is worth looking at before adding diluent. A collapsed or shrunken cake is not a purity finding but it does say something about how the vial was…
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Receptor desensitisation as a tolerance hypothesis, and its weak evidence Replied, post #53 · Pharmacology › Receptor biology · 23 Jul 2026 · 10 likes Endogenous versus pharmacological receptor engagement differ in magnitude and in duration by orders of magnitude. Arguments from "it is a natural hormone" do not…
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Transit times by route, from a logged dataset Replied, post #28 · Sourcing › Logistics · 23 Jul 2026 · 18 likes Building on post #25 rather than restating it. Customs outcomes are not predictable at the level of an individual parcel. What is predictable is that consistent,…
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What to bring: records that a clinician can actually use — a second dataset Replied, post #66 · Clinical › Prescriber conversations · 23 Jul 2026 · 5 likes Bringing a record of symptoms with dates and severities makes an assessment materially easier and is the single most useful preparation. I would treat that as a working…
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PIONEER 6 cardiovascular safety, read as a safety trial rather than an efficacy one Replied, post #7 · Compounds › Oral incretins · 18 Jul 2026 · 30 likes PIONEER 6 was a cardiovascular safety trial for oral semaglutide, not an efficacy trial. Non-inferiority for safety was demonstrated. The point estimates favoured the…
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Coming back to: Preparing for an appointment: one page, three questions Replied, post #11 · Clinical › Prescriber conversations · 18 Jul 2026 · 15 likes A question phrased as "what would you want to see before considering X" is answerable and is not a request for X. Posting it because the silence on this was starting to…
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Priming a pen and whether the primed volume is wasted Replied, post #8 · Devices › Pens & autoinjectors · 16 Jul 2026 · 0 likes Holding the pen in place for the stated count after the plunger stops is the manufacturer's answer to leakage at the site. It is on the instruction leaflet and it is…
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What to bring: records that a clinician can actually use — a second dataset Replied, post #31 · Clinical › Prescriber conversations · 13 Jul 2026 · 9 likes Post #28 answers the question as asked. The question underneath it is different. Bringing a record of symptoms with dates and severities makes an assessment materially…
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A 5 mg vial and a 0.25 mg dose: the arithmetic in full Replied, post #122 · Practice › Reconstitution · 12 Jul 2026 · 0 likes This is the first time the answer has come with its own limits attached. Appreciated.
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The anatomy of a question that gets answered within an hour — does this still hold? Replied, post #14 · Start Here › How to Ask · 11 Jul 2026 · 29 likes Bookmarking this. I will come back when I have something worth adding.
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A fridge failure and how I assessed the contents afterwards Replied, post #17 · Devices › Cold chain · 11 Jul 2026 · 0 likes Before the thread moves on from fridge failure — what is the sample size behind the claim? I am not being difficult; I have seen the same figure quoted from an n of…
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Ultrasound and skinfolds: operator dependence in practice Replied, post #52 · Outcomes › Body composition · 10 Jul 2026 · 1 like Reading back through, this was answered upthread and I missed it. My fault.