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Devices · Syringes & needles · continued

Fixed versus detachable needles: the trade-offs posts 61–90

This is a continuation of a long topic, addressed by post number rather than by page. Start at post 1 · go to the accepted answer.

SG
s.grahameTL2Member20 Dec 2024#61

Coring the stopper is a real phenomenon with repeated entries at the same point and blunt needles. Varying the entry point slightly and using a fresh needle prevents it.

This is the version I would want a new member to read first.

13 likes 19mo
RI
r.ilungaTL221 Dec 2024#62
Ziegler, post #41: Post #40 is right about the mechanism and I think understates the practical bit. Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less. Go to post

Filter needles are for drawing from glass ampoules where particulate is a real risk. For a stoppered vial they add dead volume in exchange for very little.

That is where I would start, not where I would stop.

27 likes in reply to #41 19mo
BS
buffer_sheetTL3Regular21 Dec 2024#63
r.ilunga, post #62: Filter needles are for drawing from glass ampoules where particulate is a real risk. For a stoppered vial they add dead volume in exchange for very little. That is where I would start, not where I would stop. Go to post

Taking post #62 at face value and following it one step further.

Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum.

0 likes in reply to #62 19mo
ER
e.roosTL222 Dec 2024#64

Post #60 and I disagree about the size of the effect, not about the direction.

I have three months of notes on fixed versus detachable needles and the honest summary is that the trend is real and the week-to-week numbers are noise. I nearly drew the opposite conclusion from the first fortnight.

5 likes 19mo
BE
bench_entryTL3Regular22 Dec 2024#65

Needle length: typical lengths for subcutaneous injection are 4-6 mm (short), 8 mm (standard), or 10-12 mm (longer). Longer needles are needed for deeper tissue or if you have abdominal adiposity.

I am confident about the direction and much less about the magnitude.

9 likes 19mo
BW
b.wikstromTL223 Dec 2024#66
TL4_Halvorsen, post #37: Filter needles are for drawing from glass ampoules where particulate is a real risk. For a stoppered vial they add dead volume in exchange for very little. Anyone with a larger sample, please post it. Go to post

This settles it for me, at least until somebody posts a reason it should not.

20 likes in reply to #37 19mo
BJ
b.jankowiakTL3Regular23 Dec 2024#67

Fixed versus detachable needles has a well-known answer and a correct answer, and the interesting work is establishing that they are the same. Nobody has done that here yet.

0 likes 19mo
PD
p.dialloTL224 Dec 2024 · edited#68

Post #64 put the caveat in the right place and I want to underline it.

Fixed versus detachable needles: insulin syringes usually have fixed needles (no dead volume loss to the hub). Luer-lock syringes use detachable needles (more dead volume). Fixed needles are preferred for small doses.

2 likes 19mo
O
OTeixeiraTL3Regular24 Dec 2024#69
m.stephanopoulos, post #45: Confirming post #43 from a second method, which matters more than confirming it from a second person. Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum. Go to post

The arithmetic in post #67 is right; the assumption feeding it is the part to check.

U-100 means the barrel is graduated for a solution containing one hundred units of insulin per millilitre. For anything that is not insulin, the units are simply hundredths of a millilitre.

5 likes in reply to #45 19mo
FI
f.ibarraTL225 Dec 2024#70
s.grahame, post #61: Coring the stopper is a real phenomenon with repeated entries at the same point and blunt needles. Varying the entry point slightly and using a fresh needle prevents it. This is the version I would want a new member to read first. Go to post

Answering the question post #68 raises rather than the one it answers.

The claim about fixed versus detachable needles upthread is stronger than its source supports. I have read the source. The source says "associated with" and the post says "causes".

14 likes in reply to #61 19mo
AW
a.westergaardTL3Regular25 Dec 2024 · edited#71

Sharps disposal: needles and syringes should be disposed in a sharps container (a rigid, puncture-resistant container). Do not put them in regular trash. Many pharmacies accept filled sharps containers.

If anyone has run this properly I would rather read that than my own guess.

8 likes 19mo
CF
c.falkTL226 Dec 2024#72
k.vanhecke, post #7: What I would want before treating fixed versus detachable needles as settled: the method, the sample, and whether anyone tried to find the opposite result. Two of the three are usually missing. Go to post

Reading rather than answering, but this is the post I would point somebody at.

2 likes in reply to #7 19mo
ZL
z.laurentTL226 Dec 2024#73

Post #71 put the caveat in the right place and I want to underline it.

My experience of fixed versus detachable needles contradicts the reply above. I am posting it as a data point rather than as a refutation, because one person's experience is exactly that.

0 likes 19mo
DY
d.yilmazTL227 Dec 2024#74

Gauge is the outside diameter and higher numbers are thinner. Thinner needles hurt less and draw more slowly, which is the entire trade.

19 likes 19mo
CL
c.lundgrenTL227 Dec 2024#75

Post #71 describes the usual case. This is about the unusual one.

Marking my uncertainty on fixed versus detachable needles explicitly. I am confident about the direction, much less confident about the size, and not confident at all that it generalises past the case in the first post.

12 likes 19mo
HE
h.eriksenTL228 Dec 2024#76
ni.kravchenko, post #15: I had written a reply contradicting post #13 and deleted it. Here is what survived. The practical version of fixed versus detachable needles is three sentences long. The rigorous version is three pages and reaches the same conclusion with the conditions attached. Go to post

Adding the measurement that post #75 says would settle it.

If someone has run fixed versus detachable needles properly I would rather read that than my own reconstruction of it. Posting mine only because the thread has gone quiet.

4 likes in reply to #15 19mo
ML
m.lehtinenTL228 Dec 2024#77
b.jankowiak, post #67: Fixed versus detachable needles has a well-known answer and a correct answer, and the interesting work is establishing that they are the same. Nobody has done that here yet. Go to post

The quoted dead-volume figures for common configurations vary between manufacturers and the ordering is stable: fixed needle least, luer with hub more, luer with filter needle most.

0 likes in reply to #67 19mo
NN
n.nybergTL229 Dec 2024#78

Dead volume: residual liquid in the hub and needle after withdrawal. Typical residual is 0.01 to 0.02 mL for an insulin syringe with a fixed needle. Accounting for it matters if precision matters.

26 likes 19mo
BT
baseline_tableTL2Member29 Dec 2024#79

Two people in this thread mean different things by fixed versus detachable needles and are disagreeing about the definition while believing they are disagreeing about the facts. Worth pausing to define it.

2 likes 19mo
EK
ew.kuuselaTL230 Dec 2024#80

Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less.

0 likes 19mo
NL
n.laurentTL230 Dec 2024#81

Safety-engineered needles are worth using if you have children or anyone else in the house, and the retraction mechanism occupies dead volume that ordinary syringes do not.

I would put a moderate confidence on that and no more.

6 likes 19mo
CR
compounding_ruthTL4Pharmacist31 Dec 2024#82
a.zamora, post #49: Right, and stated more narrowly than I would have dared to state it. Go to post

On post #78 — agreed on the reasoning, with one qualification.

Nobody has said the unglamorous part of fixed versus detachable needles yet, so: most of the variation is explained by things that are boring to write about and easy to check.

16 likes in reply to #49 19mo
HD
h.delgadoTL231 Dec 2024#83

Sharps containers are a legal requirement for disposal in several jurisdictions and a sensible precaution everywhere. A rigid sealed container is the minimum.

31 likes 19mo
IT
impurity_tableTL31 Jan 2025#84
SD
s.dziedzicTL21 Jan 2025#85
Ziegler, post #41: Post #40 is right about the mechanism and I think understates the practical bit. Needle gauge: smaller numbers (30G) are finer and less painful. Larger numbers (25G) are courser. For subcutaneous injection, 27-30G is typical. Finer needles take longer to draw up but hurt less. Go to post

This follows post #83 rather than contradicting it.

Needle length for subcutaneous delivery is a question about tissue depth and injection angle together. Short needles at ninety degrees and longer ones at an angle reach comparable depths.

Happy to expand any of that if it is the useful part.

10 likes in reply to #41 19mo
SC
so.cardosoTL22 Jan 2025#86
s.grahame, post #61: Coring the stopper is a real phenomenon with repeated entries at the same point and blunt needles. Varying the entry point slightly and using a fresh needle prevents it. This is the version I would want a new member to read first. Go to post

Worth separating two things that post #82 runs together.

The quoted dead-volume figures for common configurations vary between manufacturers and the ordering is stable: fixed needle least, luer with hub more, luer with filter needle most.

22 likes in reply to #61 19mo
VS
v.sjobergTL22 Jan 2025#87

This is the sort of exchange that makes the archive worth searching.

0 likes 19mo
TV
t.vasquezTL4 Moderator3 Jan 2025 · edited#88

A methods point on fixed versus detachable needles rather than a substantive one: if the comparison is not like for like, the difference you are measuring is the difference in method.

1 like 19mo
AI
a.iyerTL23 Jan 2025#89
isotonic_sheet, post #16: Confirming post #13 from a second method, which matters more than confirming it from a second person. On fixed versus detachable needles the community has more anecdote than the confidence in this thread implies, and I include my own contribution in that. Go to post

Adding the boring version of fixed versus detachable needles, because the interesting version keeps getting posted and the boring one is usually right.

Check the ordinary explanations, in order, and stop when one of them accounts for what you are seeing. Most of the time the second one does.

15 likes in reply to #16 19mo
RM
r.mcalisterTL3Regular4 Jan 2025#90
y.adebayo, post #36: My understanding of fixed versus detachable needles is a few years old and may have been superseded. If it has been, I would genuinely like to know rather than keep repeating it. Go to post

Dead volume: residual liquid in the hub and needle after withdrawal. Typical residual is 0.01 to 0.02 mL for an insulin syringe with a fixed needle. Accounting for it matters if precision matters.

30 likes in reply to #36 19mo