People with a low starting BMI: where the evidence stops

Posting this under the heading it deserves: People with a low starting BMI: where the evidence stops Everything below is what sits behind that.

Asking about a population rather than about a person.

The published trials in this class mostly enrolled a fairly specific group, and the questions here frequently come from people well outside it. I would like to understand what the honest position is when someone falls outside the studied population: not "it is fine" and not "there is no data", but what the reasoning actually looks like.

The arithmetic in post #4 is right; the assumption feeding it is the part to check.

Extrapolating a point estimate to somebody well outside the enrolled range should be described as an extrapolation every time it is done.

One case, stated as one case.

Post #10 answers the question as asked. The question underneath it is different.

Adolescent evidence exists for some compounds in this class and is a separate approval decision with its own trials rather than an extension of the adult data.

The evidence for this is thinner than the way I have phrased it suggests.

Dedicated trials in under-studied populations are the only real remedy and several are ongoing, which is worth saying rather than speculating.

I have changed my mind on this once already, so take it as current rather than settled.

Nothing in this subcategory is medical advice and the questions asked here are precisely the ones that need an individual assessment.

I am aware this is the third time this month I have made this point.